Yellow Root

Generic name: Xanthorhiza Simplicissima Marshall.
Brand names: Parsley-leaved Yellow Root, Shrub Yellow Root, Yellow Root, Yellow Wart

Usage of Yellow Root

Yellow root may exhibit properties similar to those of goldenseal and Barberry because of the presence of berberine; however, limited experiments have been reported with X. simplicissima. See the Goldenseal and Barberry monographs.

In vitro and animal data

Antimicrobial activity has been described,(Okunade 1994) and in vitro inhibition of leukemia cell replication has been demonstrated.(Baker 1989)

Clinical data

Research reveals no clinical data regarding the use of yellow root for any condition. However, results from 2 low-quality controlled trials (one translated from Chinese to English via Google translate) reported significant within-group improvements in diastolic and/or systolic blood pressure with administration of berberine to adults with primary hypertension. Between-group comparisons were not reported. DoSage was 300 and 500 mg administered 3 times daily for 8 weeks and 3 months in patients with concomitant gout and newly diagnosed type 2 diabetes, respectively.(Suadoni 2020)

Yellow Root side effects

Information is lacking; however, clinical trials using berberine report minor GI adverse effects.Kumar 2015

Before taking Yellow Root

Avoid use during pregnancy.Kumar 2015 The chemical constituent berberine crosses the placenta, is transferred through breast milk, and has been associated with jaundice and kernicterus in neonates.Kumar 2015

How to use Yellow Root

There is no clinical evidence to support dosing recommendations for yellow root. Doses of 0.5 to 1 tsp of the powdered root bark taken up to 3 times a day have been documented.Duke 2002 Yellow root may be used as an adulterant in goldenseal preparations.

Warnings

A case report of toxicity after drinking yellow root tea for 2 years has been attributed to arsenic contamination.Parsons 1981 Information on X. simplicissima whole plant extract is lacking. Berberine is a naturally occurring active constituent in the root, rhizome, and stem bark of many medicinally important plants, with no genotoxic, cytotoxic, or mUTAgenic effects reported with clinical doses.Kumar 2015

What other drugs will affect Yellow Root

None well documented.

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