Zanaflex

Generic name: Tizanidine
Drug class: Skeletal muscle relaxants

Usage of Zanaflex

Zanaflex is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.

Zanaflex is used to treat spasticity associated with diseases like multiple sclerosis and spinal cord injuries by temporarily relaxing muscle tone.

Zanaflex may also be used for purposes not listed in this medication guide.

Zanaflex side effects

Get emergency medical help if you have signs of an allergic Reaction to Zanaflex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

weak or shallow breathing;

confusion, hallucinations; or

yellowing of the eyes or skin.

pain or burning when you urinate.

Common Zanaflex side effects may include:

drowsiness, dizziness, weakness;

dry mouth;

feeling nervous;

blurred vision;

flu-like symptoms;

abnormal liver function tests;

runny nose, sore throat;

urination problems, painful urination;

vomiting, constipation; or

uncontrolled muscle movements.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zanaflex

You should not use Zanaflex if you are allergic to tizanidine, or if:

you also take the antidepressant fluvoxamine (Luvox); or

you also take the antibiotic ciprOfloxacin (Cipro).

To make sure Zanaflex is safe for you, tell your doctor if you have ever HAD:

liver disease;

kidney disease; or

low blood pressure; or

high blood pressure.

It is not known whether Zanaflex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using tizanidine. Ask your doctor about any risk.

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How to use Zanaflex

Usual Adult Dose for Muscle Spasm:

-Initial dose: 2 mg orally every 6 to 8 hours as needed -The dose of Zanaflex can be increased by your doctor if needed -The medication effects peak in about 1 to 2 hours and last for 3 to 6 hours -Do not take more than 16mg of Zanaflex at one time. Do not take more than 36mg in 24 hours.

Comments: -The capsules and tablets are absorbed differently by the body. Do not switch from one to the other without talking to your doctor. -Zanaflex should be taken with food every time or without food every time. Do not switch back and forth.

Warnings

Zanaflex is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.

You should not take tizanidine if you are also taking fluvoxamine (Luvox) or ciprofloxacin (Cipro).

Do not use Zanaflex at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Switching between Zanaflex tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take Zanaflex, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.

Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of tizanidine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these other medicines together with Zanaflex.

Avoid drinking alcohol. It can increase some of the side effects of tizanidine.

What other drugs will affect Zanaflex

Taking Zanaflex with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

acyclovir;

ticlopidine;

zileuton;

birth control pills;

an antibiotic, including ciprofloxacin, Levofloxacin, moxifloxacin, ofloxacin, or others;

blood pressure medicine such as clonidine, guanfacine, methyldopa;

heart rhythm medicine including amiodarone, mexiletine, propafenone, verapamil; or

stomach acid medicine such as cimetidine, Famotidine.

This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

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