Zemdri

Generic name: Plazomicin
Drug class: Aminoglycosides

Usage of Zemdri

Zemdri is an antibiotic medicine used to treat serious infections of the bladder or kidneys.

Zemdri can cause serious or disabling side effects that may not be reversible. Zemdri should be used only for infections that cannot be treated with a safer antibiotic.

Zemdri may also be used for purposes not listed in this medication guide.

Zemdri side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Zemdri can harm your kidneys, and may also cause nerve damage or hearing loss.

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

dizziness, spinning sensation;

a light-headed feeling, like you might pass out;

hearing loss, a buzzing or roaring sound in your ears (during or after treatment with Zemdri);

muscle weakness; or

kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath.

Serious side effects may be more likely in older adults.

Common side effects of Zemdri may include:

nausea, vomiting, diarrhea;

headache; or

feeling light-headed.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zemdri

You should not use Zemdri if you are allergic to Zemdri or similar antibiotics such as amikacin, gentamicin, kanamycin, neomycin, paromomycin, streptomycin, or tobramycin.

Zemdri is not approved for use by anyone younger than 18 years old.

Tell your doctor if you have ever had:

kidney disease; or

nerve-muscle disorder such as myasthenia gravis.

Do not use Zemdri if you are pregnant. This medicine may cause hearing loss in the newborn baby. Use effective birth control, and tell your doctor if you become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

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How to use Zemdri

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Zemdri is given as an infusion into a vein, every 24 to 48 hours. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use Zemdri if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Zemdri is usually given for 4 to 7 days. Follow your doctor's dosing instructions very carefully.

Drink plenty of liquids while you are using Zemdri.

You may need frequent blood or urine tests. Your hearing, kidney function, and nerve function may also need to be checked.

Store in the refrigerator, do not freeze.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Warnings

Zemdri can harm your kidneys, and may also cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines.

What other drugs will affect Zemdri

Zemdri can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).

Other drugs may affect Zemdri, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.