Zemplar

Generic name: Paricalcitol (oral/injection)
Drug class: Vitamins

Usage of Zemplar

Zemplar is a synthetic (man-made) form of vitamin D. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Zemplar is used to treat or prevent overactive parathyroid gland (hyperparathyroidism) in people with chronic kidney disease who are on dialysis.

Zemplar oral capsules are for use in adults and children at least 10 years old. The injection is for use in adults and children at least 5 years old.

Zemplar side effects

Get emergency medical help if you have signs of an allergic reaction to Zemplar: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

fast, slow, or pounding heartbeats;

fever, flu symptoms, mouth and throat ulcers;

new or worsening cough, fever, trouble breathing;

a seizure; or

high calcium levels - nausea, vomiting, loss of appetite, constipation, increased thirst or urination, confusion, weight loss, tiredness.

You may be more likely to have a broken bone if your parathyroid hormone levels get too low. Talk with your doctor about how to avoid the risk of fractures.

Common Zemplar side effects may include:

nausea, vomiting;

swelling in your hands or feet;

dizziness or spinning sensation;

joint pain; or

runny nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zemplar

You should not use Zemplar if you are allergic to paricalcitol, or if you have high levels of vitamin D or calcium in your body.

You should not be treated with Zemplar injection if you have ever had a severe allergic reaction to it previously.

To make sure Zemplar is safe for you, tell your doctor if you have:

high blood pressure;

liver disease; or

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

Tell your doctor if you are pregnant or breastfeeding.

If you breastfeed while receiving Zemplar injection, watch for signs of hypercalcemia in your baby (such as feeding problems, vomiting, constipation, or seizure).

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How to use Zemplar

Usual Adult Dose for Secondary Hyperparathyroidism:

Injectable: Initial dose: 0.04 to 0.1 mcg/kg (2.8 to 7 mcg), injected as a bolus dose through a hemodialysis vascular access port at any time during dialysis Maximum frequency: Every other day Comments: -Do not inject directly into a vein. Use: Prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease Stage 5. ----- Oral: Initial dose: Stage 3 or 4 Chronic Kidney Disease (CKD): Initial dosing is based on baseline intact parathyroid hormone (iPTH): -500 pg/mL or less: 1 mcg orally daily OR 2 mcg orally 3 times a week -Over 500 pg/mL: 2 mcg orally daily OR 4 mcg orally 3 times a week Stage 5 CKD: Starting dose (micrograms) = baseline iPTH level (pg/mL)/80 Starting dose is given orally 3 times a week; only start if baseline serum calcium has been adjusted to 9.5 mg/dL or lower. Comments: -If giving 3 times a week, do not give more often than every other day. Use: Prevention and treatment of secondary hyperparathyroidism associated with: -Chronic Kidney Disease (CKD) stages 3 and 4 (oral product only), or -CKD stage 5 on hemodialysis or peritoneal dialysis (oral or injectable).

Usual Pediatric Dose for Secondary Hyperparathyroidism:

Safety and efficacy have not been established in pediatric patients. The following is dosing used in a very small pediatric trial. No data are available on children under 5 years old. Initial dose, children 5 to 18 years: 0.04 mcg/kg three times per week if baseline intact parathyroid hormone (iPTH) is less than 500 pg/mL 0.08 mcg/kg three times per week if baseline iPTH is 500 pg/mL or higher -Injected as a bolus dose through a hemodialysis vascular access port at any time during dialysis Maximum frequency: Every other day Comments: -Do not inject directly into a vein. Use: Prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease Stage 5.

Warnings

You should not use Zemplar if you have high levels of calcium or vitamin D in your blood.

Before taking Zemplar, tell your doctor if you have high blood pressure, liver disease, or an electrolyte imbalance.

Do not take other vitamin or mineral supplements unless your doctor has told you to.

Avoid using calcium supplements or antacids without your doctor's advice. Use only the specific type of supplement or antacid your doctor recommends. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

While using this medicine, you may need blood tests at your doctor's office. Visit your doctor regularly.

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of vitamin D can cause serious or life-threatening side effects.

Overdose symptoms may include headache, weakness, drowsiness, dry mouth, nausea, vomiting, constipation, muscle or bone pain, metallic taste in the mouth, weight loss, itchy skin, changes in heart rate, loss of interest in sex, confusion, unusual thoughts or behavior, feeling unusually hot, severe pain in your upper stomach spreading to your back, or fainting.

What other drugs will affect Zemplar

Some medicines can make paricalcitol much less effective when taken at the same time. If you take any of the following medicines, take your oral Zemplar dose 1 hour before or 4 to 6 hours after you take the other medicine:

cholestyramine; or

mineral oil.

Tell your doctor about all your current medicines. Many drugs can interact with paricalcitol, especially:

digoxin (digitalis);

a diuretic or "water pill";

nefazodone;

a phosphate binder - ferric citrate, sevelamer, lanthanum carbonate;

an antibiotic - clarithromycin, telithromycin;

antifungal medicine - itraconazole, ketoconazole; or

antiviral medicine to treat HIV/AIDS - indinavir, nelfinavir, ritonavir, saquinavir.

This list is not complete and many other drugs may interact with paricalcitol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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