Zenpep
Generic name: Pancrelipase
Drug class:
Digestive enzymes
Usage of Zenpep
Zenpep contains a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.
Zenpep is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.
Zenpep may also be used following surgical removal of the pancreas.
Zenpep side effects
Get emergency medical help if you have signs of an allergic reaction to Zenpep: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Tell your doctor if your child is not growing at a normal rate while using Zenpep.
Common Zenpep side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Zenpep
You should not take Zenpep if you are allergic to pork proteins.
To make sure Zenpep is safe for you, tell your doctor if you have ever had:
It is not known whether Zenpep will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether pancrelipase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without medical advice.
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How to use Zenpep
Usual Adult Dose of Zenpep for Pancreatic Exocrine Dysfunction:
Initial: lipase 500 units/kg orally per meal. Maintenance: Lipase 400 to 2500 units/kg orally per meal. Give one-half the usual dose with each snack. Maximum: Total daily dose should not exceed 10,000 lipase units/kg body weight/day.
Usual Adult Dose of Zenpep for Cystic Fibrosis:
Initial: lipase 500 units/kg orally per meal. Maintenance: Lipase 400 to 2500 units/kg orally per meal. Give one-half the usual dose with each snack. Maximum: Total daily dose should not exceed 10,000 lipase units/kg body weight/day.
Usual Adult Dose for Chronic Pancreatitis:
8000 to 36,000 lipase USP orally with each meal. In patients with pancreatectomy or obstruction of pancreatic ducts, lipase 8000 to 16,000 USP orally taken at 2-hour intervals or as directed by physician.
Usual Pediatric Dose for Pancreatic Exocrine Dysfunction:
Less than 1 year: 2000 to 4000 units per 120 mL of formula, breast milk, or per breast-feeding Greater than 1 to less than 4 years: Initial dose: 1000 units/kg/meal Dosage range: 1000 to 2500 units/kg/meal Greater than or equal to 4 years: Refer to adult dosing. In cystic fibrosis, the powder is given as one-fourth teaspoonful (0.7 g) with meals.
Usual Pediatric Dose for Cystic Fibrosis:
Less than 1 year: 2000 to 4000 units per 120 mL of formula, breast milk, or per breast-feeding Greater than 1 to less than 4 years: Initial dose: 1000 units/kg/meal Dosage range: 1000 to 2500 units/kg/meal Greater than or equal to 4 years: Refer to adult dosing. In cystic fibrosis, the powder is given as one-fourth teaspoonful (0.7 g) with meals.
Warnings
You should not take Zenpep if you are allergic to pork proteins.
Call your doctor at once if you have symptoms of a rare but serious bowel disorder: severe or unusual stomach pain, vomiting, bloating, diarrhea, or constipation.
What other drugs will affect Zenpep
Other drugs may interact with pancrelipase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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