Zerit

Generic name: Stavudine
Drug class: Nucleoside reverse transcriptase inhibitors (NRTIs)

Usage of Zerit

Zerit is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Zerit is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

Zerit is not a cure for HIV or AIDS.

Zerit side effects

Get emergency medical help if you have signs of an allergic reaction to Zerit: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have:

numbness, tingling, or pain in your hands or feet;

weakness in your legs, feet, arms, or hands;

liver problems - swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

pancreatitis - fever, severe pain in your upper stomach spreading to your back, nausea and vomiting.

Stavudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Zerit side effects may include:

weakness, numbness, tingling, or burning pain in your hands or feet;

nausea, vomiting, diarrhea;

rash; or

headache;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zerit

You should not take Zerit if you are allergic to stavudine. Do not take this medicine with didanosine or zidovudine, or with any other medicine that contains stavudine.

Zerit can cause severe or life-threatening effects on your liver or pancreas. Tell your doctor if you have liver disease or a history of pancreatitis.

Tell your doctor if you have ever had:

kidney disease (or if you are on dialysis);

liver disease, including hepatitis C;

diabetes (Zerit liquid may contain sucrose);

gallstones;

numbness, tingling, or pain in your hands or feet;

problems with your pancreas; or

if you drink large amounts of alcohol.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Relate drugs

How to use Zerit

Usual Adult Dose for HIV Infection:

Less than 60 kg: 30 mg orally every 12 hours 60 kg or more: 40 mg orally every 12 hours

Usual Adult Dose for Nonoccupational Exposure:

Less than 60 kg: 30 mg orally every 12 hours 60 kg or more: 40 mg orally every 12 hours Duration: Prophylaxis should be initiated as soon as possible, within 72 hours of exposure, and continued for 28 days. In general, the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis include Zerit as part of protease inhibitor (PI)-based regimens.

Usual Pediatric Dose for HIV Infection:

Birth to 13 days: 0.5 mg/kg orally every 12 hours 14 days or older: Less than 30 kg: 1 mg/kg orally every 12 hours 30 kg or more: Adult dosage recommended.

Warnings

Do not take Zerit with didanosine or zidovudine, or with any other medicine that contains stavudine.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

Zerit can also cause serious or life-threatening effects on your liver or pancreas. Call your doctor at once if you have: stomach pain or swelling, fever, nausea, vomiting, easy bruising or bleeding, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

What other drugs will affect Zerit

Tell your doctor about all your other medicines, especially:

hydroxyurea.

This list is not complete. Other drugs may interact with stavudine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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