Zestril

Generic name: Lisinopril
Dosage form: oral tablet (2.5 mg; 5 mg; 10 mg; 20 mg; 30 mg; 40 mg)
Drug class: Angiotensin Converting Enzyme Inhibitors

Usage of Zestril

Zestril (lisinopril) is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years of age and older.

Zestril is also used in adults to treat congestive heart failure and to improve survival after a heart attack.

Zestril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

Zestril side effects

Get emergency medical help if you have signs of an allergic reaction to Zestril: severe stomach pain, hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Zestril may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

high blood potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;

low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough;

kidney problems - swelling, urinating less, feeling tired or short of breath; or

liver problems - loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Zestril side effects may include:

headache, dizziness;

low blood pressure, cough; or

chest pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zestril

You should not use Zestril if you are allergic to lisinopril or to any other ACE (angiotensin converting enzyme) inhibitor such as Captopril, fosinopril, enalapril, Benazepril, moexipril, perindopril, quinapril, ramipril, or trandolapril.

Do not take Zestril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not take Zestril with any medication that contains aliskiren (a blood pressure medicine).

Do not take Zestril if you have a history of angioedema (severe allergic reaction).

To make sure Zestril is safe for you, tell your doctor if you have ever had:

heart disease, heart problems such as a recent heart attack;

low blood pressure;

low white blood cell count;

stomach pain;

if you are on a low-salt diet;

diabetes;

liver disease; or

kidney disease (or if you are on dialysis).

You may also need to avoid taking Zestril with aliskiren if you have kidney disease.

Stop using this medicine and tell your doctor right away if you become pregnant. Zestril can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

Do not breastfeed.

Relate drugs

How to use Zestril

Usual Adult Dose for Hypertension:

Initial dose: 10 mg orally once a day; 5 mg orally once a day Maintenance dose: 20 to 40 mg orally once a day Maximum dose: 80 mg orally once a day Comments: -The initial dose is 5 mg orally once a day in patients receiving a diuretic. -The 80 mg dose is used but does not appear to give greater effect. -If blood pressure is not controlled with Zestril alone, a low dose of a diuretic may be added (e.g., hydrochlorothiazide, 12.5 mg). After the addition of a diuretic, it may be possible to reduce the dose of Zestril.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2.5 to 5 mg orally once a day Maintenance dose: Dosage should be increased as tolerated Maximum dose: 40 mg orally once a day Comments: -The diuretic dose may need to be adjusted to help minimize hypovolemia, which may contribute to hypotension. The appearance of hypotension after the initial dose of Zestril does not preclude subsequent careful dose titration with the drug.

Usual Adult Dose for Myocardial Infarction:

Initial dose: 5 mg orally (within 24 hours of the onset of acute myocardial infarction) Subsequent doses: 5 mg orally after 24 hours, then 10 mg orally after 48 hours. Maintenance dose: 10 mg orally once a day. Dosing should continue for at least 6 weeks. Comments: -Therapy should be initiated at 2.5 mg in patients with a low systolic blood pressure (less than or equal to 120 mm Hg and greater than 100 mmHg) during the first 3 days after the infarct. If prolonged hypotension occurs (systolic blood pressure less than 90 mmHg for more than 1 hour) therapy should be withdrawn. Uses: Reduction of mortality in acute myocardial infarction

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 10 to 20 mg orally once a day Maintenance dose: 20 to 40 mg orally once a day Dosage may be titrated upward every 3 days Comments: -Not an approved indication.

Usual Geriatric Dose for Hypertension:

Initial dose: 2.5 to 5 mg orally once a day Maintenance dose: Dosages should be increased at 2.5 mg to 5 mg per day at 1 to 2 week intervals. Maximum dose: 40 mg orally once a day

Usual Pediatric Dose for Hypertension:

Pediatric patients greater than or equal to 6 years of age: Initial dose: 0.07 mg/kg orally once a day (Maximum initial dose is 5 mg once a day) Maintenance dose: Dosage should be adjusted according to blood pressure response at 1 to 2 week intervals. Maximum dose: Doses above 0.61 mg/kg or greater than 40 mg have not been studied in pediatric patients Comments: -This drug is not recommended in pediatric patients less than 6 years old or in pediatric patients with glomerular filtration rate less than 30 mL/min.

Warnings

Do not use Zestril if you are pregnant. It could harm the unborn baby. Stop using this medicine and tell your doctor right away if you become pregnant.

You should not use this medicine if you have ever had angioedema. Do not take Zestril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use Zestril together with any medication that contains aliskiren (such as Amturnide, Tekturna, Tekamlo).

You may also need to avoid taking Zestril with aliskiren if you have kidney disease.

What other drugs will affect Zestril

Lisinopril can harm your kidneys, especially if you also use certain medicines for infections, cancer, or osteoporosis.

Tell your doctor about all your other medicines, especially:

a diuretic or "water pill" that may increase blood potassium such as spironolactone, triamterene, or amiloride;

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;

insulin or diabetes medications;

medicine to prevent organ transplant rejection such as temsirolimus, sirolimus, or everolimus; or

heart or blood pressure medication.

This list is not complete. Other drugs may affect Zestril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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