Ziac

Generic name: Hydrochlorothiazide And Bisoprolol
Drug class: Beta blockers with thiazides

Usage of Ziac

Ziac contains a combination of hydrochlorothiazide and bisoprolol. Hydrochlorothiazide is a thiazide diuretic (water pill). Bisoprolol is a beta-blocker.

Ziac is used to treat high blood pressure (hypertension).

Ziac tablets are available in three different strengths; 2.5 mg/6.25 mg (bisoprolol fumarate 2.5 mg and hydrochlorothiazide 6.25 mg), 5 mg/6.25 mg (bisoprolol fumarate 5 mg and hydrochlorothiazide 6.25 mg), and 10 mg/6.25 mg (bisoprolol fumarate 10 mg and hydrochlorothiazide 6.25 mg).

Ziac side effects

Get emergency medical help if you have signs of an allergic reaction to Ziac (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

chest pain;

fast, slow, or uneven heartbeats;

a light-headed feeling, like you might pass out;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

shortness of breath (even with mild exertion), swelling, rapid weight gain;

liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

signs of an electrolyte imbalance - increased thirst or urination, constipation, muscle pain or weakness, leg cramps, numbness or tingling, feeling jittery, irregular heartbeats, fluttering in your chest, or a choking feeling;

low blood sugar - headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky.

Common Ziac side effects may include:

dizziness;

feeling weak or tired;

diarrhea, nausea, indigestion;

headache; or

cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ziac

You should not use Ziac if you are allergic to hydrochlorothiazide or bisoprolol, or if you have:

severe or uncontrolled heart failure;

slow heartbeats that have caused you to faint;

a serious heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree);

an allergy to sulfa drugs; or

if you are unable to urinate.

To make sure Ziac is safe for you, tell your doctor if you have:

congestive heart failure;

asthma or other breathing disorder;

diabetes;

a thyroid disorder;

glaucoma;

peripheral vascular disease such as Raynaud's syndrome;

kidney disease;

liver disease (or cirrhosis);

lupus;

gout; or

an allergy to sulfa drugs or penicillin.

It is not known whether Ziac will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using this medicine.

Ziac is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Ziac

Usual Adult Dose of Ziac for Hypertension:

Initial dose: Bisoprolol 2.5 mg-Hydrochlorothiazide 6.25 mg orally once a day Maximum dose: Bisoprolol 20 mg-Hydrochlorothiazide 12.5 mg orally once a day Comments: -Increase the dose every 14 days if optimal response not achieved. -This drug may be substituted for titrated individual components (e.g., inadequate control on bisoprolol 2.5 to 20 mg or adequate control on hydrochlorothiazide 50 mg but with significant potassium loss). -Abrupt discontinuation should be avoided; taper therapy gradually over approximately 2 weeks. -If withdrawal symptoms occur, therapy may be temporarily reinstituted.

Warnings

You should not use Ziac if you are unable to urinate. You should not use Ziac if you have a serious heart condition such as "sick sinus syndrome" or "AV block," severe heart failure, or slow heartbeats that have caused you to faint.

Before using Ziac, tell your doctor if you have congestive heart failure, circulation problems, kidney or liver disease, cirrhosis, glaucoma, asthma, bronchospastic lung disease, a thyroid disorder, lupus, gout, diabetes, or a penicillin allergy.

If you are diabetic, check your blood sugar carefully. Using bisoprolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking Ziac. Talk with your doctor before changing any doses.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Keep using Ziac even if you feel fine. High blood pressure often has no symptoms

What other drugs will affect Ziac

Tell your doctor about all your other medicines, especially:

colestipol or cholestyramine;

insulin or oral diabetes medicine;

lithium;

sedatives or narcotic medicine;

heart or blood pressure medicine - clonidine, digoxin, diltiazem, disopyramide, reserpine, verapamil, and others;

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or

steroid medicine - prednisone and others.

This list is not complete. Other drugs may interact with hydrochlorothiazide and bisoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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