Zinbryta

Generic name: Daclizumab
Drug class: Interleukin inhibitors

Usage of Zinbryta

Zinbryta is a monoclonal antibody that affects the actions of the body's immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Zinbryta is used to treat relapsing forms of multiple sclerosis.

Zinbryta is usually given when other medicines have not been effective.

Zinbryta is available only from a certified pharmacy under a special program. You must be registered in the program and understand the risks and benefits of taking this medicine.

Zinbryta side effects

Get emergency medical help if you have signs of an allergic reaction to Zinbryta: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

pale or yellowed skin, confusion or weakness;

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);

pain or burning when you urinate;

shortness of breath;

liver problems - loss of appetite, upper stomach pain, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

any type of infection - sudden weakness or ill feeling, fever, chills, swollen glands, mouth sores, trouble swallowing, cold or flu symptoms; or

symptoms of depression - sadness, crying spells, drowsiness, trouble concentrating, anger, aggression, feeling hopeless or irritable, or having thoughts about suicide or hurting yourself.

Your treatment may be delayed if you have certain side effects.

Common Zinbryta side effects may include:

cold symptoms (stuffy nose, sinus pain, sore throat);

flu symptoms (fever, body aches, sore throat, swollen glands);

cough, chest tightness;

mouth pain;

depressed mood;

rash or itching;

dry flaky skin; or

abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zinbryta

You should not use Zinbryta if you are allergic to daclizumab, or if you have ever had:

liver disease; or

a history of autoimmune hepatitis.

To make sure Zinbryta is safe for you, tell your doctor if you have:

an active infection, including tuberculosis;

liver problems, including hepatitis B or C;

skin problems such as eczema or psoriasis;

depression; or

if you are scheduled to receive any vaccines.

It is not known whether Zinbryta will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether daclizumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding a baby.

Zinbryta is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Zinbryta

Usual Adult Dose for Multiple Sclerosis:

17 years and older: 150 mcg suBCutaneously once a month Comments: -Sites for injection are the thigh, abdomen, and back of the upper arm. -If a dose is missed within 2 weeks of the scheduled dose, it should be given immediately and the original monthly dosing schedule should be resumed. -If a dose is missed and it is more than 2 weeks from the scheduled dose, the missed dose should be skipped and the original monthly dosing schedule should be resumed. -Only one dose should be administered at one time. Use: For the treatment of adult patients with relapsing forms of multiple sclerosis (MS) who have had an inadequate response to 2 or more drugs

Warnings

You should not use Zinbryta if you have liver disease or if you have ever had autoimmune hepatitis.

Zinbryta can cause serious or fatal liver problems. Call your doctor right away if you have symptoms such as nausea, vomiting, upper stomach pain, tiredness, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

You will need frequent blood tests to check your liver function during treatment and after you stop using this medicine. Future doses may be delayed based on the results of these tests.

Zinbryta may also increase your risk of certain infections or immune system problems. Call your doctor if you have a skin rash, fever, swollen glands, diarrhea, stomach pain, blood in your stools, or any other new or unusual symptoms.

What other drugs will affect Zinbryta

Daclizumab can harm your liver. This effect is increased when you also use certain other medicines, including: antibiotics, tuberculosis medicine, antifungal medicine, birth control pills or hormone replacement therapy, certain antidepressants, heart or blood pressure medication, a "statin" cholesterol medication, seizure medicine, and some pain or arthritis medicines (including acetaminophen, Tylenol, Advil, Motrin, and Aleve).

Many drugs can interact with daclizumab. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.