Zinecard

Generic name: Dexrazoxane
Drug class: Miscellaneous uncategorized agents

Usage of Zinecard

Zinecard is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications.

The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications.

Zinecard is also used to help prevent chemotherapy-related heart problems in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is given only after you have received enough doxorubicin infusions to amount to a certain total dose.

Zinecard may also be used for purposes not listed in this medication guide.

Zinecard side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

Zinecard may cause serious side effects. Call your doctor at once if you have:

fever, chills, tiredness, mouth sores, skin sores;

easy bruising, unusual bleeding;

sore throat, cough, trouble breathing; or

bruising, swelling, warmth, redness, oozing, or bleeding of any surgical incision.

Common side effects of Zinecard may include:

nausea, vomiting;

fever;

infection after a surgery; or

pain where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Zinecard

You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication such as:

daunorubicin (Cerubidine, Daunoxome);

epirubicin (Ellence);

idarubicin (Idamycin); or

mitoxantrone (Novantrone).

Tell your doctor if you have ever had:

heart problems;

liver disease; or

kidney disease.

Zinecard can harm an unborn baby or cause birth defects if the mother or the father is receiving this medicine. Women should use effective birth control to prevent pregnancy while receiving this medicine and for at least 6 months after the last dose. Men should use birth control during treatment and for at least 3 months after the last dose. Tell your doctor right away if a pregnancy occurs during this time.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because Zinecard may harm the baby if a pregnancy does occur.

You should not breastfeed while you are using Zinecard. Women receiving Totect should continue to not breastfeed for at least 2 weeks after the last dose.

Relate drugs

How to use Zinecard

Zinecard is given as an infusion into a vein. A healthcare provider will give you this injection.

Totect is usually started within 6 hours after extravasation, and continued once daily for 3 days.

Zinecard is usually started 15 minutes before you receive your doxorubicin infusion. Zinecard is not given with your first dose of doxorubicin, but only after you've received prior doxorubicin doses up to a certain total amount.

Zinecard can add to bone marrow suppression caused by chemotherapy. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

Warnings

Zinecard can harm an unborn baby or cause birth defects if the mother or father is using Zinecard. Tell your caregivers if you are pregnant, or if you are a man and your sex partner is able to get pregnant.

You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication (such as daunorubicin, epirubicin, idarubicin, or mitoxantrone).

Tell your doctor at once if you have signs of infection such as fever, chills, sore throat, easy bruising or bleeding, skin sores, or warmth and redness of any surgical incision.

What other drugs will affect Zinecard

Tell your doctor about all your other medicines, especially:

other cancer medications; or

dimethyl sulfoxide (DMSO).

This list is not complete. Other drugs may affect Zinecard, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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