10% Egis Lidocaine spraying in place anesthetic indications (38g)

Dosage form Box x 38g
Specifications Lidocaine

Ingredient

Composition information	Content
Lidocaine	10%

Uses

indications

10%lidocaine drug is indicated in the following cases:

Lidocaine is indicated for anesthetic at the mucosa. The drug is suitable for anesthetic for a short time in the following cases:

In dentistry

In dentistry and oral surgery, when anesthesia is needed. It is also possible to use in surgery such as incising a shallow abscess, extracting tooths that are about to shake, remove bone fragments and sew wounds in the mucosa. Other use purposes include anesthesia for gums to attach crowns or bridges, remove by hand or with tools (or remove) of hypertrophic slit.

Lidocaine spraying reduces or inhibits the inductance of the pharynx when preparing to take X -rays. Only use drugs with rubber teeth markers.

Contraindicated when plaster is used to remove teeth because there is a risk of suction into the lungs. Lidocaine spraying can be used when removing healing and superficial mucosa. Can use drugs in children when cutting the jaw and when the incision opens the salivary gland.

In the Faculty of Ear Nose Throat

In the Ear Nose and Otolaryngology Department, to treat nosebleeds before burning electricity, cutting the nasal wall and removing the nasal polyps. The drug is also used before tonsillectomy to inhibit the pharynx reflexes and to anesthetize in the injection site. The drug is also used for additional anesthesia before the incision opens an abscess around the tonsils or before teasing the sinus.

Can use lidocaine spray to anesthetize before sinus washing. Before using spraying in the pharynx or nose surgery, it should be noted that Lidodcaine inhibits the pharynx reflexes and spreads to the larynx and trachea and thus also inhibits cough reflexes, which can lead to bronchitis.

Do not use lidocaine spray to anesthetize local anesthesia before tonsillectomy and VA scrap in children under 8 years old.

The aforementioned caution is very important in children because the child's swallow reflexes occur more than in adults.

In laparoscopy and instrument examination, to anesthetize the pharynx before inserting the tube through the nose or mouth (duodenum pipes, before conducting a segmented test meal) as well as before the rectal scanner and when replacing Cancer.

In gynecology and obstetrics, to anesthetize the perineum and to conduct and/or treat the tricks of the vulva. Lidocaine spraying is also suitable for anesthesia in surgery in vaginal surgery or in an uterus surgery. It is also possible to use drugs when incising or when treating hymen or abscess.

In the Faculty of Dermatology, to anesthetize the skin and mucosa in minor surgery.

Pharmacokinus

lidocaine is an amide -type local anesthetic, in the I/B group that stabilizes cell membranes and anti -arrhythmia as it has been classified by Vaughan William. Anesthetic by preventing the formation and transmission of neuroma pulse.

Local anesthesia - including lidocaine - acts by stabilizing the permeability of nerve cell membranes for sodium ions. The stimulation threshold increases gradually and thus inhibits the transmission.

When used on the spot on the mucosa, Lidocaine is absorbed more or less depending on the dosage and position. The circulating flow in the mucosa affects the absorption. The effect of Lidocaine spraying occurs within 1 minute and lasts for 5-6 minutes. The numbness slowly disappears within 15 minutes. With treatment doses, the drug does not affect the heart rate and does not reduce the heart muscle contraction (inhibiting heart).

Dynamic pharmacokinetics

Metabolism

lidocaine is rapidly metabolized by the enzymes from the mini of the liver cells, the elimination of n -alkylation N is oxidized within a few minutes. The metabolic speed seems to be limited by the circulating flow in the liver, and the result may be reduced in patients after myocardial infarction and/or congestive heart failure.

Lidocaine is metabolized produced by monoethylglycinexylidide (Megx) and glycinexylidide. Both of these metabolites have a more anti -arrhyce effect than the original drug.

Distribution

The places where the drug is distributed includes:

Tissue: The drug is distributed into blood tissues, such as kidneys, lungs, liver and heart. The drug is also distributed into adipose tissue.

The placenta: Lidocaine passes through the placenta by dynamic penetration. The passing through each other can be enough to enter the fetus and reach the toxic concentration. Lidocaine passes through the placenta quickly, appearing during the fetal circulation within a few minutes after the mother took the drug.

Attached to protein: The cohesion of lidocaine in plasma depends on the concentration of the drug in plasma and the concentration of alpha-1-acid glycoprotein (AAG). The attachment to the protein of Lidocaine has been recorded from 33% to 80%. It is found that the attachment to the protein of plasma increases in patients with high urea and in people with kidney transplantation, and increased after acute myocardial infarction. In the future, it is also characterized by an increase in AAG concentration. The increase in protein may reduce the comfort of free lidocaine or even causing increased drug concentration in total plasma.

Before taking 10% Egis Lidocaine spraying in place anesthetic indications (38g)

How to use

Use in the form of spraying pump pump into the mucosa, each pump will produce 4.8mg lidocaine on the surface.

Dosage

Dosage varies depending on the instructions and area of the area to be anesthetized. To avoid high levels of drugs in plasma, it is important to use the lowest dose that gives satisfactory results. Usually 1-3 times the pump is sufficient, although in obstetrics can use up to 15-20 times the pump or more (up to 40 times the pump for 70 kg of body weight).

Instructions for dosage for different indications:

Indications Dosage (Number of pumps) 4 3

Children

Documents in literature show that it is also possible to use lidocaine spray for children in dentistry and oral surgery, preferably in the form of topical so as not to make children fear when pumping the drug and also to avoid the feeling of stinging often complaining as side effects. This method can also be applied to children under 2 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Must be smoothly held through ventilation, and for oxygen and/or artificial respiration.

Sometimes seizures occur and are treated early as soon as they appear by 50 - 100mg of successlcholine and/or 5 - 15mg Diazepam. Short -acting barbiturat drugs like Thiopental may also be helpful.

Differences are ineffective during the level of overdose Lidocaine.

can use Atropine to handle cardiovascular symptoms. Giving 0.5 - 1.0mg of Atropine by intravenously can help regulate slow heart rate and disorder, while drugs have sympathetic nerve -like effects along with the beta receptor owner used when low blood pressure.

If you have cardiac arrest, you need to massage your heart immediately.

What to do when forgetting a dose?

Side Effects

When using 10%lidocaine medicine , you may experience unwanted effects (ADR).

Light stinging sensation (burning) when pumping the drug will end when the numbness appears (within 1 minute).

allergic reactions ( anaphylactic shock ) with lidocaine spraying are rarely occur. It is rare for side effects on the central nervous system (for example, restlessness and/or depression) and the cardiovascular system (for example, low blood pressure, slow heart rate).

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

10%lidocaine drug contraindicated in the following cases:

Hypersensitivity to lidocaine or a history of convulsions when taking this medication, hypersensitivity to the ingredients of the drug.

Atrial Block - Furniture II -III and conduction disorders in ventricular.

Adams-Stokes syndrome, serious slow heartbeat and sinus syndrome.

heart shock.

The function of left ventricle is significantly reduced.

Caution when using

is especially cautious when taking the drug in cases such as liver function damage, circulatory impairment, low blood pressure, impaired kidney function and epilepsy; In these cases, the drug should be reduced. It is also necessary to be particularly cautious when the mucosa is damaged, the elderly and/or the patient is exhausted and those who have been taking drugs in the Lidocaine group to treat heart disease.

Do not spray into the throat of children under 2 years old. Instead, use spray in the form of a cotton swab.

Lidocaine passes through the each other a few minutes after intravenous injection, so if you use spraying pets with recommended dose, it is not dangerous for the mother. When using lidocaine for breastfeeding women, they must consider the previous benefits.

Spraying pets causes burning sensation at the beginning of the pump.

When the pump must hold the bottle vertically. Do not allow spraying to come into contact with the eyes, and it is important to avoid letting spraying from the pavement lines (the risk of sucking into the lungs). Special prudence when pumping drugs in the pharynx.

Allergic reactions are very rare with lidocaine spray.

The ability to drive and operate machinery

unless the side effects make it uncomfortable and there is no limit in driving and operating machinery.

pregnancy

can use lidocaine spray when pregnant because the recommended treatment dose is not harmful to the mother.

The period of breastfeeding

When used for women who are breastfeeding, they must consider dangerous.

Interactive drug

The following drugs increase lidocaine levels in serum: chlorpromazine, cimetidine, propranolol, pettidine, bupivacain, quinidine, disopyramide, amitryptiline, imipramine and nortriptyline.

Coordinate with drugs of group I/A (such as Quinidine, Procainamide, Disopyramide), which leads to a prolonged QT segment, and rarer may be atrial block or vibration.

Phenytoin increases the upper inhibitory effect of lidocaine.

Lidocaine combination with processaamide can cause nerve side effects (delirium, hallucinations).

Lidocaine may increase the effects of neurological blockers because the drug reduces the transmission at the nerve -muscle connection points.

In the case of Digitalis poisoning, Lidocaine can make the atrial block more serious.

Alcohol abuse increases the respiratory inhibiting effects of lidocaine.

Storage

Store drugs at temperatures between 15 - 25 ° C, under normal conditions. Avoid too high temperatures and direct sunlight.

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