2% Medipharco 2% Medipharco skin cream, urticaria, insect burner (1 tube x 10g)

Dosage form Cream
Specifications Box of 1 tube x 10g
Ingredient Promethazine

Ingredient

Thành phần cho 5g

Composition information	Content
Promethazine	100mg

Uses

Indications

Promethazin Cream 2% Medipharco - a dermatological drug, indicated to treat itching, skin irritation such as itching, urticaria, insect bites.

Pharmacokic

Promethazin is a phenothiazin conductor that has different structures that are different from mental disorder phenothiazin in the auxiliary branch circuit and no replacement in the ring. It is thought that this configuration reduces dopaminergic effect in the central nervous system (only 1/10 of Clopromazin's effect). Promethazine has antihistamine and sedative effects. However, the drug can also stimulate or paradoxically inhibit the central nervous system.

Central neurological inhibitors, sedative manifestations, are common when taking drugs with treatment dose for antihistamine.

Promethazin is a H1 receptor blocker due to a dispute with histamine in the positions of the H1 receptor on the acting cells, but does not prevent the release of histamine, so the drug only prevents the histamine -generated reactions. Promethazine is antagonistic at different levels, with most but not all, the pharmacological effects of histamine, including urticaria, itching. In addition, the anti -cholinergic effect of most antihistamine drugs also causes dry nose and oral mucosa.

Promethazine and most antihistamine drugs pass through the blood -brain barrier, causing sedative effects due to n -methyltransferase histamine inhibitors and select central histamine receptors. This is a special risk for young children, because antihistamine drugs have been shown to cause death due to sleep apnea.

The antagonism in other receptors of the TKT system, such as serotonin, acetylcholin can also occur. It is thought that indirect phenothiazine reduces the stimulation of the cerebral body system.

Promethazin is resistant to cholinergic, preventing response to acetylcholin via Muscarinic receptor.

Promethazin and other phenothiazin have the effect of alpha blockers - adrenergic, which causes the risk of hypotension

pharmacokinetics

Promethazin is well absorbed through the gastrointestinal tract and in the injection site. The drug concentration in plasma is needed to have antihistamine and sedative effects that are not well known. The antihistamine effect can last up to 12 hours or longer, and the sedative effect can be maintained from 2 to 8 hours depending on the dose and sugar.

The ratio of binding with plasma proteins is from 76 to 93%. The drug is widely distributed to the body's tissues. Although the concentration in the brain is lower than other parts, it is still higher than the plasma concentration. The drug is easy through the placenta. It is not clear whether the drug is distributed in breast milk.

Promethazin metabolizes strongly in the liver for the main product, Promethazin Sulphoxid and N - Demethyl Promethazin. Eliminating drugs through urine and feces, mostly in the form of promethazin sulphoxid and glucuronid form.

Before taking 2% Medipharco 2% Medipharco skin cream, urticaria, insect burner (1 tube x 10g)

How to use

Apply medication.

Dosage

Apply Promethazin into thin layer on sick skin, 3-4 times daily.

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

Symptoms: Mainly anti -cholinergic effects at the central level, inhibitors and epilepsy.

Epilepsy treatment: Intravenous Diazepam intravenously 5 - 10 mg (children 0.1 - 0.2 mg/kg). A very serious case will appear antiolinergic symptoms in TKTW such as stimulating state, hallucinations, can be treated with physostigmin intravenously 1 - 2 mg (children 0.02 - 0.04 mg/kg), the drug is slowly injected to determine the right dose of the drug. Can be reminded after 30-60 minutes. Atropine is prepared for use in case of overdose physostigmin.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects that may occur when using Promethazin skin cream include:

Skin rash, sensitive to light, atopic dermatitis, jaundice.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

topethazin cream 2% contraindicated in the following cases:

There is a history of sensitivity to the ingredients of the drug.

Children under 2 years old.

Be cautious when using

only applied to the skin, if there is a phenomenon of non -tolerance on the spot, it is necessary to stop treatment.

Promethazin Cream also needs to be used with serious epilepsy or cardiovascular, liver failure or marrow failure.

Pay attention to any abnormal sensitivity to sunlight when using the drug. Stop drug if needed.

Use drugs for women during pregnancy and lactation

Pregnant women

Not determined safety when using Promethazin Cream for pregnant women. Therefore, only promethazin should be used for pregnant people when the benefits of treatment are more likely to occur for
fetus.

Women who are breastfeeding

Not determined safety for nursing mothers, so it is necessary to be cautious when used for breastfeeding people because of the risk of unwanted effects that can occur in children.

Antihistamine drugs can inhibit milk secretion due to anti -anti -anti -cholinergic effects.

The effect of the drug on the ability to drive and operate machinery

Need to pay attention when using the drug for the driver and operate machinery because the Promethazin is sedative.

Interactive drug

With the skin -using form, Promethazin has no significant interaction for other drugs.

Medication interactions can affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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