20% albutein infusion grifols treatment of volume reduction (50ml)

Dosage form Box X 50ml
Specifications Human Albumin
Ingredient Alpha

Ingredient

Composition information	Content
Human Albumin	20%

Uses

indications

20% albutein drug is indicated in the following cases:

Restores and maintains circulating blood in places that have proven the lack of volume, and use the appropriate glue. About 10% of liver protein synthesis.

Data Physics: Albumin Human 200 g/l has the effect of increasing tone of the corresponding force.

The most important physiological function of albumin is the result of its contribution to blood pressure and transportation function. Albumin stabilizes the amount of circulating blood and is the transportation of hormones, enzymes, drugs and toxins.

Dynamic pharmacokinetics

Under normal conditions, the total amount of albumin can be exchanged is 4 - 5 g/kg body weight, of which 40 - 45% are present in the circuit and 55 - 60% in the outer space. Increasing the permeability of capillaries will change albumin kinetics and abnormal distribution may occur in conditions such as severe burns or infections.

Under normal conditions, the average selling time for albumin is about 19 days. The balance between synthesis and decomposition is usually achieved by the feedback regulations. The elimination is mainly intracellular and by protease lysosome.

In healthy people, less than 10% of albumin is transmitted from the internal compartment in the first 2 hours after transmission. There is a significant change in individuals in affecting plasma volume. In some patients, plasma volume may still increase in several hours. However, in patients with serious illness, albumin may leak out of the vascular space at a significant amount at an unpredictable speed.

Before taking 20% albutein infusion grifols treatment of volume reduction (50ml)

How to use

albumin people can be used directly by intravenously, or can also be diluted in the isothermal solution (for example: 5% glucose or 0.9% sodium chloride).

The transmission speed must be adjusted depending on the case and indications.

In plasma exchange, the transmission speed must be adjusted according to the elimination speed.

Dosage

concentration of albumin preparations, dosage and transmission speed must be adjusted according to patient personal requirements.

The necessary dosage depends on the patient's appearance size, the severity of injury or disease and the loss of liquid and protein continues. Should use the volume measurement, not plasma albumin levels to determine the necessary dosage.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? When the first clinical signs of cardiovascular overload (headache, shortness of breath, intravenous obstruction), or hypertension, central venous hypertension and pulmonary edema, should stop immediately and carefully monitor the patient's hemodynamic parameters.

What to do when forgetting 1 dose?

Side Effects

When using 20%albutein, you may experience unwanted effects (ADR).

Mild reactions such as flushing, urticaria, fever and nausea rarely occur. These reactions often disappear quickly when the speed of transmission is slowed or stopped. Very rarely occur serious reactions such as shock. In these cases, it is advisable to stop transmission and start appropriate treatment.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

20% albutein drugs in the following cases:

Hypersensitivity to albumin preparations or any excipients.

Be cautious when using

suspected allergic reactions or anaphylaxis should stop inject immediately. In case of shock, standard medical treatment for shock should be done.

Albumin should be used carefully in the condition of increased blood volume and its consequences or blood thinning can cause special risk to the patient. Examples of such conditions are:

Uncount heart failure.

Hypertension.

The glue osmotic effect of the albumin is 200 g/l approximately four times compared to plasma. Therefore, when using concentrated albumin, be careful to ensure patients are fully hydrated. Patients should be carefully monitored to prevent circulation and water increase.

The albumin solution of 200 g/l has a relatively low electrolyte content compared to the albumin solution of 40 - 50 g/l. When transmitting albumin, it is necessary to monitor the patient's electrolyte status and take appropriate steps to restore or maintain electrolyte balance.

Albumin solution is not diluted with water for injection because it can cause hemolysis in the recipient.

If you need to replace the relatively large volume, blood clotting and hematocrite are required. It is necessary to be careful to ensure full replacement of other components in the blood (coagulation factors, electrolytes, platelets and red blood cells).

Hyperbonemia may occur if the dosage and transmission speed are not adjusted to suit the patient's circulatory situation. When the first clinical sign of cardiovascular overload (headache, shortness of breath, intravenous obstruction), or increased blood pressure, increased venous pressure and pulmonary edema, must stop infusion immediately.

Standard measures to prevent infections due to the use of drug products made from blood or plasma include the selection of donor donor, screening for each donated individual and plasma tank to find signs of specific infections and include effective production steps to eliminate virus activity/ remove viruses. However, when using drug products made from human blood or plasma, it is impossible to completely eliminate the ability to transmit infections. This also applies to unknown or emerging viruses and other pathogens.

There is no report on virus transmission with albumin produced according to European pharmacopoeia standards by established processes.

We especially recommend that every time you use albutein 200 g/l for patients, the name and lot number of the product are recorded to maintain the relationship between the patient and the product lot.

Special warning about excipients:

This drug contains 7.3 mmol (166.8 mg) sodium per vial of 50 ml and 14.5 mmol (333.5 mg) sodium per bottle of 100 ml. Note by patients who are dieting with controlled sodium.

This drug product contains potassium, less than 1 mmol (39 mg) each bottle.

The ability to drive and operate machinery

has no effect on the ability to drive and use machines.

Pregnancy

The safety of albutein 200 g/l to use for pregnant women has not been set in controlled clinical trials. However, clinical experience with albumin shows no harmful effects on pregnancy, either for fetuses and babies.

There are no animal reproductive studies conducted with Albutein 200 g/l.

Experienced animal studies are not enough to assess the safety level for reproduction, embryo or fetal development, pregnancy and development of birth and postpartum.

However, human albumin is a normal component of human blood.

The period of breastfeeding

There has been no research on the use of albutein in humans as well as animals during breastfeeding. Only use when needed.

Interactive drug

There is no specific interaction of albumin with other drug products known.

Storage

Do not store over 30 ° C. Do not freeze.

Keep the jar in the external carton box to avoid light.

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