20% SmoFlipid 20% Fresenius Kabi provides energy, fatty acids (100ml)

Dosage form Bottle x 100ml
Specifications Soybean oil, triglycerides, medium-chain, olive oil, fish oil

Ingredient

Composition information	Content
Soybean oil	6g
Triglycerides, medium-chain	6g
Olive oil	6g
Fish oil	3G

Uses

Indications

SmoFlipid 20% Kabi 100ml is indicated in the following cases:

The treatment for energy and essential fatty acids and omega - 3 fatty acids for patients, as part of the venous nourishment, when nourished by eating or through the gastrointestinal tract is not sufficient or contraindicated.

Pharmacokinatus

Fat emulsion has the size of the feces and biological characteristics similar to endogenous micro -micro -micro -micro -microorganisms. The composition of SmoFlipid (Soybean oil, medium triglyceride, olive oil, fish oil) in addition to energy supply, has its own pharmacokinetic characteristics.

Soybean oil has a high content of essential fatty acids. Omega - 6 Linoleic fatty acids are the most (about 55 - 60%). Omega - 3 Alpha - Linolenic fatty acids have about 8%. This part of the oil in SmoFlipid emulsion provides essential amounts of essential fatty acids.

Average fatty acids quickly oxidize and provide the body with rapid metabolic energy.

Oil - Liu mainly provides energy in the form of non -stormed fatty acids, a double -connected fatty acids that are less likely to be oxidized compared to the amount of equivalent of unsaturated fatty acids.

Fish oil is characterized by high content of Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). DHA is an important component of the cell membrane, while EPA is the substrate of eicosanoids such as prostaglandin, tromboxan and leucotrien.

Vitamin E protects fatty acids against fat oxidation.

pharmacokinetics

separate trigiycerides have different clearance speeds but SmoFlipid is a mixture that is faster than long vascular triglycend (LCT) with lower blood triglycerides when emulsion. O - Li oil has the slowest metabolic speed among the components of the emulsion (even slower than the LCT) and the average triglycend (MCT) with the fastest metabolic speed. Fish oil in the mixture with LCT has the same metabolic speed as the metabolic speed of the monomer.

Before taking 20% SmoFlipid 20% Fresenius Kabi provides energy, fatty acids (100ml)

How to use

20% SmoFlipid Kabi 100ml using peripheral intravenous or central veins.

Dosage

depending on the ability to metabolize the amount of fat transmitted into the patient, adjusting the dose and transmission speed, seeing caution and warning to adults.

Standard dose is 1.0 - 2.0g of fat/kilogram of weight/day, corresponding to 5 - 10ml/kg body weight/day.

Suggested transmission speed is 0.125g of grease/kg body weight/hour, corresponding to 0.63ml SmoFlipid/kg body weight/hour and should not exceed 0.15g of fat/kg body weight/hour, corresponding to 0.75ml SmoFlipid/kg body weight/hour.

For babies and children

The initial dose should be 0.5 -1.0g of grease/kg body weight/day, then increased by 0.5 -1.0g of fat/kg body weight/day.

The maximum dose is 3.0g of grease/kilogram of weight/day. Do not exceed the recommended dose of 3.0g of fat/kilogram of body weight/day, corresponding to 15ml of SmoFlipid/kg body weight/day. The transmission speed should not exceed 0.125g of fat/kg body weight/hour.

For babies born prematurely and underweight, it is recommended to transmit Smoflipid continuously for 24 hours.

For children

Do not exceed the recommended dose of 3.0g of fat/kilogram of weight/day, corresponding to 15ml of SmoFlipid/kg body weight/ivory. Should gradually increase the daily dose in the first week of medication. The transmission speed should not exceed 0.15g of fat/kg body weight/hour.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose can lead to side effects (see unwanted effects, fat overload symptoms). In these cases, it is advisable to stop transmitting fat, or if needed to be transmitted, the dose should be reduced.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Smoflipid 20% Kabi 100ml, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: slightly increase body temperature.

Uncommon, 1/1000

Digestive: loss of appetite, nausea, vomiting.

Systemic: chills.

Rare, 1/10000

Respiratory: Difficulty breathing.

Cardiovascular: Reduce/Hypertension. Body: Hypersensitivity reactions (anaphylactic reactions or allergic reactions, urticaria redness, blushing, headache), hot or chills, pale back pain in the back of the neck, bones, chest and waist.

Very rare, ADR

Reproduction: penis erection.

If these unwanted effects occur or if the level of triglycerides while the transmission is higher than 3mmol/l, it should stop transflipid or if it is necessary to continue the dose should be reduced.

SmoFlipid emulsion is always part of the intravenous nourishing mode with amino acids and glucose. Nausea, vomiting and hyperglycemia are the stagnation of the condition that is indicated for intravenous nurturing and sometimes related to intravenous nurturing regime.

Need to monitor blood sugar and blood triglycerides to avoid the case of these levels increasing and may be detrimental.

Symptoms of fat overload

The ability to metabolize triglycend is reduced, leading to symptoms of fat overload, possibly due to overdose. Metabolic overload signs need to be monitored. The cause may be genetic (individual difference and metabolism) or due to the mechanism of fat metabolism affected by a history of disease or diseases that are suffering from. This symptom can also be encountered when increasing blood triglycend seriously, even if the transmission rate follows the instructions and is related to the sudden changes in the patient's clinical condition, such as renal function or infection.

Symptoms of fat overload such as increased blood fat, fever, fatty, enlarged liver or not accompanied by jaundice, hypertrophy of spleen, anemia, leukemia, thrombocytopenia, coagulation disorders, hemolysis and mesh red blood cells, abnormal and coma testing tests. Symptoms can often be relieved when stopping fat emulsion. If signs of fat overload symptoms are detected, Smoflipid should be discontinued.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

20% Kabi 100ml SmoFlipid drugs in the following cases:

Hypersensitivity to the protein of fish, eggs, soy, peanuts or any ingredients of this product.

Excessive high level of blood fat.

serious liver failure.

Serious coagulation disorders.

Serious renal failure without dialysis or hemorrhage.

acute shock.

General contraindications for intravenous transmission: such as acute pulmonary edema, excess fluid, loss of heart failure.

Instant condition (for example, after injury, diabetes loss, acute myocardial infarction, rules, intravenous inflammation, metabolic acidosis and severe infection and dehydration).

Precautions when using

Personal fat metabolism and thus need to be monitored by medical staff as usual. Usually, check the blood triglyceride level. Special attention should be noted for patients at risk of increased blood fat (for example, patients are indicated for high -dose fat transmission, severe infections, babies who give birth too lightly). The concentration of triglycerides in the blood should not exceed 3mmol/l when infusing. Consider reducing the dose or stopping the fat emulsion if the concentration of triglycerides in the blood when transmitted or after transmission is exceeding 3mmol/l. Overdose can lead to fat overload symptoms.

This drug contains soybean oil, fish oil and phospholipids from eggs that can cause allergic reactions. The cross -allergic reaction has been observed between soy and peanuts.

Be careful when using Smoflipid in patients with lipid metabolism, often found in patients with renal impairment, diabetes, pancreatitis, liver failure, thyroid failure and infection.

Documents about use on diabetes or renal failure are limited.

Modeling medium vascular fatty acids can lead to metabolic acidosis. This risk is largely limited by simultaneous transmission of long vascular fatty acids in Smoflipid. The use of carbohydrates will limit this risk.

Therefore, it is necessary to convey with the carbohydrate solution or carbohydrate amino acid solution. Common tests for monitoring venous nurturing should be conducted regularly. These tests include blood sugar tests, liver function tests, acid -base metabolism, physical fluid balance, blood and electrolyte testing tests.

If there is any anaphylactic reaction (such as a fever, shivering, skin redness or shortness of breath), decide to stop transmitting immediately.

Be cautious when transferring Smoflipid to infants and premature babies with increased bilirubin and cases of patients with pulmonary hypertension, in newborns, especially premature babies need to provide long -term intravenous nutrition, need to monitor platelet counting results, liver function tests and triglyceride concentration in the blood.

High blood fat levels can cause noise for blood tests, such as red blood cells.

Should avoid adding other drugs or other substances to SmoFlipid emulsion unless the compatibility is known.

The ability to drive and operate machinery

There has been no report on the effect of drugs on driving or operating the machine. However, it is necessary to warn the patient when taking the drug that can cause hypersensory reactions leading to headaches.

Pregnancy and lactation

There is no document on the risk of SmoFlipid for pregnant or lactating women. There are no studies on animal reproductive toxicity. Nursing through intravenously may be needed during pregnancy and lactation. SmoFlipid should only be used for pregnant and lactating women after considering.

Medicinal interaction

Heparin used in clinical doses leads to an increase in the fleeting increase of lipoprotein lipase during circulation: Initially can increase blood fat resolution, followed by a transient decrease and clearing of triglycerides in blood.

Soybean oil has vitamin K1 in natural ingredients. Small content in SmoFlipid is not considered to have a significant impact on the blood clotting process of patients being treated with cooumarin drugs.

Storage

Store at a temperature not exceeding 30 ° C. Not frozen.

Only use if the emulsion is homogeneous. Check the naked eye to detect if there is a phase division before use. It is necessary to make sure that after shaking thoroughly, emulsion does not have any phase division.

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