3% Novocaine injection solution Vinphaco penetrates, regional anesthesia, spinal anesthesia (100 tubes x 2ml)

Dosage form 100 tube box
Specifications Procaine hydrochlorid

Ingredient

Thành phần cho 2ml

Composition information	Content
Procaine hydrochlorid	60mg

Uses

Indications

Novocaine 3% are indicated for treatment in absorbent anesthesia and regional anesthesia, spinal anesthesia, sympathetic nerve closing or peripheral nerves to reduce pain in some cases.

Pharmacokic

Procaine hydrochloride is a ester of Para Aminobenzoic acid that has a short -term anesthetic effect. The drug is attached to the receptor on Na+ channel in neuron cell membranes, stabilizing the cell membrane, does not allow Na+ to enter the cell, so the neuron cell membrane does not remove, so the active voltage should not spread and followed by the transmission of the nerve pulse.

In addition, processes can affect the central nervous system (stimulating and/ or inhibitors), the cardiovascular system (reducing the transmission and stimulation of the heart) to relax the peripheral vessel. The drug reduces less pain because the drug does not spread through the tissues. The drug is not anesthetized by the surface because it does not absorb through the membrane. Procaine has an inferior anesthetic effect 3 times and 4 times cocaine, 3 times less toxic than cocaine.

pharmacokinetics

absorption and distribution

After the injection is decomposed quickly and almost entirely by pseudocholinesterase to become para acid - aminobenzoic acid and diethyl aminethanol. The drug has an 8% and half -lifetime -life protein ratio for a few minutes

Metabolism and elimination

About 30% of diethyl aminethanol eliminates through the urine, the rest is metabolized in the liver. About 80% of Para acid - Aminobenzoic acid in the form of conjugate and unprocessed form are eliminated through urine, the rest is metabolized in the liver.

Before taking 3% Novocaine injection solution Vinphaco penetrates, regional anesthesia, spinal anesthesia (100 tubes x 2ml)

How to use

Medicine for injection.

Dosage

When anesthesia by processes need resuscitation, oxygen as well as other emergency drugs. The dose here is the average dose for a person in general, so it is necessary to adjust the dose according to the tolerance of each individual, the area of the anesthetic area, the distribution of blood vessels in the anesthetic area and the anesthetic technique.

Validic anesthesia

When the spinal cord is diluted, the process is diluted 10% with physiological saline or glucose solution or distilled water or brain juice. Depending on the site of spinal anesthesia, the proportion/diluted solution ratio varies from 1/1 to 2/1. Injecting speed: 1 ml in 5 seconds.

recommended dose for spinal anesthesia:

The volume of 10% solution (ml)

The volume of fluid to dilute (ml)

Total dose (mg)

Penal

0.5

Wednesday.

100

Tuesday and Wednesday.

200

Monday, Tuesday, Wednesday.

In case of using a 0.25% or 0.5% process of hydrochloride or 0.5% to anesthesia, the absorbent injection can be used with a dose of 350 - 600 mg.

Neurotic block

To manipulate the peripheral nervous seal, the common dose is 500 mg of hydrochloride process with 0.5% solution (100 ml), 1% (50 ml) or 2% (25 ml). Maximum dose can be used for 1000 mg. To prolong the effect of processes in cases of peripheral nerve anesthesia or an anesthetic can be mixed with adrenalin into the process solution so that the final concentrations of Adrenalin are 1/200,000 or 1/100,000.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects on the central nervous system, cardiovascular, or unusual organs due to an increase in the high blood process levels due to overdose, or too fast absorption drug due to careless injection into blood vessels.

improper spinal anesthesia techniques, incorrect doses, overcurrent inhibition of spinal cord can lower blood pressure and apnea. The drug can also cause sensitive reactions or due to a specific phenomenon or due to a decrease in tolerance with normal dose.

less or rare

Central nervous system: stimulating, dizziness, blurred vision, convulsions. However, there may also be patients with signs of drowsiness or convulsions, coma, respiratory arrest.

Cardiovascular: inhibit myocardial muscle contraction, lower blood pressure. In some cases may experience hypertension, slow heart rate, even cardiac arrest.

Skin: common skin damage allergic reactions, urticaria, and quincke edema. In fact, skin tests to detect allergies with Procaine are less meaningful.

Like other local anesthesia, the process rarely encountered a specific reaction that causes anaphylactic shock. No relevance between dosage and anaphylactic reaction.

When the spinal anesthesia may experience some unwanted effects such as other nervous, cardiovascular, respiratory and digestive anesthetic. Neurology: headache after spinal anesthesia, meningitis syndrome, loss of orientation, vibration, spider inflammation, paralysis. Cardiovascular: Hypotension due to paralysis of vasomotor center and blood accumulation in the venous cavity.

Respiratory: Respiratory disorders or respiratory paralysis due to excessive anesthetic concentration in the chest and neck area.

digestive: nausea, vomiting.

Instructions on how to handle ADR

Stop immediately when there are ADR symptoms.

Maintain ventilation by respiratory support or artificial ventilation.

For circulatory failure: intravenous infusion, use vasoconstriction, stimulates myocardial contraction like epinephrin.

Case of convulsions: Supply oxygen and Diazepam intravenous infusion or Barbiturat group sleeping pills have a very short effect time or muscle relaxants with short effects.

For spinal anesthesia: Monitoring blood pressure should be monitored during anesthetic, if the blood pressure appears, it is necessary to maintain blood pressure by vasoconstrilic substances such as intravenous or intramuscular epinephrin.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

3% Novocaine drug contraindicated in the following cases:

Atrial block - Ventricular 2.3.

Children under 30 months old. Sensitive to sulfite.

allergies: asthma, urticaria. Procaine circuit for people with muscle weakness.

Be cautious when using

due to the toxicity of the heart, need to be cautious when used for people with arrhythmia, atrioventricular block or shock. Safety and effectiveness of the spinal cord depending on the dosage, anesthetic technique, adequate caution and ready to emergency with the condition of each patient, so it is necessary to choose the lowest dose that has anesthetic effect without increasing the concentration of drugs too high in the blood and unwanted effects.

In patients with labor or increased pressure in the abdomen, elderly, weakness, liver failure need to reduce the dose.

In some diseases such as shock, hypertension, anemia, kidney damage, metabolic disorders or endocrine, intestinal obstruction, peritonitis, etc.The physician consider carefully between the benefits and the risk of making decisions to use the process to anesthesia.

in the process solution contains sodium disulfit or sodium sulfit, so it can cause allergic reactions, may even cause anaphylactic shock or bronchial asthma attacks in some people, especially in people with a history of allergies or bronchial asthma.

Inject the right anesthetic area. Do not be injected into the pulse or directly into the nerves.

Stop immediately if there is any abnormal expression.

The ability to drive and operate machinery

should not drive and operate machinery when not completely alert and out of unwanted effect after taking the drug. Need to ask more about the doctor.

There are no studies on the influence of Candesartan on the ability to drive and use machines. However, when treated with this drug, it can cause dizziness and fatigue.

Pregnancy

Procaine has been used for pregnant women but has not seen notice of unwanted effects on the development of the fetus. However, it is also very careful to use processes in pregnant women, especially in the first months of pregnancy.

The period of breastfeeding

Because the process has a very short lifetime (1 minute), the excretion of medicine has not been studied.

Drug interaction

Vascular shrink substances such as adrenalin slowly absorb the process into the bloodstream, extending the anesthetic time.

anti -cholinesterase such as cyclophosphamide, thiotepa, pesticides, demecarium, isoflurophy can inhibit process metabolism, thus increasing the risk of poisoning.

Sulfonamid and Salicylic Acid: Under the catalyst of cholinesterase, the process converts into para acid aminobenzoic, thus reducing the activity of sulfonamid and salicylic acid.

Diuretics: Acetazolamid is half -life of the process.

Suxamethonium: Procaine may increase the neurotransmitter effect of suxamethium.

Cavalry

Procaine hydrochloride is similar to aminophylin, barbiturate, magnesium sulfate, sodium phenitoin, sodium bicarbonate and amphoticin b.

Do not mix alkaline or carbonate solution.

Storage

Leave a cool dry place, avoid light, temperature below 30 ° C.

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