5% braun glucose solution for carbohydrate deficiency and compensation for the body (500ml)

Dosage form 10 bottles
Specifications Sodium chloride, glucose monohydrate

Ingredient

Composition information	Content
Sodium chloride	4.5g
Glucose monohydrate	27.5g

Uses

Indications

Glucose 5% is indicated in the following cases:

Carbohydrate deficiency and compensation for the body.

is a solution of transportation and diluted solvent for compatible drugs for intravenous infusion.

Pharmacy

Low concentration glucose solutions are suitable to dilute drugs due to glucose as a natural substance of cell cells, metabolized everywhere. Under glucose physiological conditions, carbohydrates provide the most important energy with calories of 17 kJ/kg or 4 kcal/g, in adults, normal glucose concentration in the blood is reported of 60 - 100 mg/100 ml, or 3.3 - 5.6 mmol (when hungry).

Disorders using glucose (glucose intolerance) may occur under pathological metabolism. These cases are mainly diabetes and metabolic stress (for example, during and after surgery, serious illness, trauma), decline in hormone glucose absorption, which can even cause hyperglycemia without external supply. Hyperglycemia - depending on its severity, can lead to loss of fluid loss through the osmotic pressure and lead to dehydration, disorders due to osmotic pressure and can lead to coma due to osmotic pressure.

pharmacokinetics

When the first transmission glucose will enter the circuit and then enter the intracellular. During glucose hydrolysis is converted into pyruvat or lactate. Lactat may be partially put into glucose transformation (Cori ring). In aerobic condition, pyruvat is completely oxidized into carbon dioxid and water. The final product of completely oxidation glucose is excreted in the lungs (carbon dioxid) and the kidney (water).

Before taking 5% braun glucose solution for carbohydrate deficiency and compensation for the body (500ml)

How to use

The solution is used intravenously (peripheral veins or central veins).

When the solution is used to dilute and as a substance that transports intravenous medications, the use of drugs will determine the appropriate volume for each treatment therapy. 5% glucose intravenous transmission is a solution to balance osmotic pressure.

Be cautious before processing or transmitting drugs

Before conducting drug transmission, 5% glucose transmission should be checked for the naked eye to urinate and color before transmission, according to the instructions on the packaging, labels of the solution. Only use the transparent solution, no urination or any impurities are seen and the packaging is not damaged. Should proceed immediately after connecting to the transmission line.

The solution should be transmitted with aseptic devices and using aseptic technique should be connected to the solution to prevent the system.

Supplementing electrolytes can be indicated according to the patient's clinical needs.

Add drugs can be included before or while transmission at the transmission position. When added, the ultimate osmotic pressure of the solution needs to be checked. The solution of solution with high osmotic pressure levels can lead to venous irritation and venous inflammation. The blend of any additional drug needs to be done carefully, under careful sterile conditions is a mandatory requirement. The solution containing additional drugs should be used immediately and not stored.

Please see the "Note when used" section when used for the risk of gas congestion.

Dosage

Adults, the elderly and children

The concentration and dose of intravenous glucose solutions are determined by many factors including age, weight and clinical condition of the patient. Serum glucose levels may need to be monitored carefully.

recommended dosage to treat carbohydrates and compensate for the body

Adults

500 ml - 3 l/24 hours.

infants and children

0 - 10 kg body weight: 100 ml/kg/24 hours.

The transmission speed depends on the clinical condition of the patient.

The transmission rate does not exceed the patient's glucose oxidation ability to avoid hyperglycemia. Therefore, the maximum range is from 5mg/kg/minute in adults to 10 - 18mg/kg/minute in young children and children depending on age and total body mass.

The recommended dosage when used is the transport or solvent diluted solvent from 50 to 250ml per dose of the drug used for transmission.

When 5% glucose is used as a diluted solvent for the injection preparations of other drugs, the dose and the transmission speed are decided mainly by the properties and dosage of prescribed drugs.

Pediatric patients

The speed and volume of transmission depend on the age, weight, clinical condition and glucose metabolism of patients, simultaneous treatment therapies and should be decided by the consulting doctor who has experience in intravenous infusion treatment in pediatric patients.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Overdose can lead to water retention, electrolyte imbalance and acidosis, hyperglycemia, and serum osmotic pressure (leading to coma due to hyperglycemia, osmotic pressure).

Emergency treatment, detoxification

depends on the type and severity of the disorders. Stop transmitting, supplementing electrolytes, taking diuretics or insulin.

What to do when forgetting a dose?

Side Effects

When using 5%glucose, you may experience unwanted effects (ADR).

Unknown frequency

The immune system: Anaphylaxis, hypersensitivity.

Nutrition and metabolism: Electrolyte imbalance, hypotension, hypoglycemia, hypoglycemia, blood sugar, hyperglycemia, dehydration, increased blood volume.

Skin, subcutaneous tissue: rash. kidney, urinary tract: multi -urinary. blood vessel: venous thrombosis, intravenous inflammation.

Common disorders and status in the transmission position: chills, fever, infection at the transmission position, irritation at the transmission position, for example, the erythema, escape, reaction at the location of the transmission, local pain.

The manifestation may occur in patients with allergies to corn or corn products. Other undesirable effects are reported with glucose infusion including: hypoglycemia, symptoms may be symptomatic.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

5% contraindicated glucose in the following cases:

Glucose intolerance is known to be different (such as pathological metabolism).

coma due to increased osmotic pressure, hyperglycemia, lactate in the blood.

Hypersensitivity to pharmaceutical substances.

See the note when using and unwanted effects in case of corn allergies or products from corn.

Precautions when using

dilution and other effects on serum electrolytes

Depending on the volume, transmission speed and depending on the clinical condition of the patient, the ability to metabolize glucose, glucose intravenous infusion may cause:

Increased osmotic pressure, osmotic and dehydration.

Electrolyte disorders such as hypoglyc sodium, hypoglycemia, hypoglycemia, blood stasis/increased blood volume, for example, obstruction includes pulmonary obstruction and edema.

The above effects are not only the result of infusion containing free electrolytes but also by glucose.

Hypoglyc sodium can lead to acute sodium hypoglycemia with typical signs such as headache, nausea, seizures, sleep, coma, brain edema and death.

Children, the elderly, women, patients after surgery, patients with hypoxia and patients with central nervous system disease or thirst for many mental births are at risk for this complication.

Periodic clinical and subclinical assessments may be necessary to monitor changes in fluid balance, electrolyte concentration and acid-base balance during prolonged transmission treatment or whenever patient condition or transmission speed guarantees such assessments.

Special prudence is recommended in patients at risk of increased water and electrolyte disorders and more serious electrolytes due to free water load, hyperglycemia or may be required to injection insulin (see below).

Hyperglycemia

Quick transmission of glucose solutions can cause significant hyperglycemia and osmotic hypertension syndrome.

If increased blood sugar occurs, adjust the transmission speed or inject insulin.

If necessary, added venous potassium.

5% glucose intravenous infusion should be cautious in the following patients:

impaired glucose tolerance (such as in patients with diabetes, renal failure, or infection, injury, or shock).

Severe malnutrition (the risk of forming feeding syndrome - see below).

Thiamin shortage, for example in chronic alcoholic patients (the risk of severe lactic acidosis due to pyruvate oxidation decline).
Water and electrolyte disorders may be worse due to glucose or free water load.
Patients with stroke due to ischemia or serious brain injury. Avoid transmission within the first 24 hours after head injury. Strictly monitoring blood sugar because of early hyperglycemia associated with bad results in patients with serious brain injury.

infants.
Effects on insulin excretion
prolonged glucose intravenous and hyperglycemia can lead to a reduction in insulin secretion rate.
Hypersensitivity reactions
Hypersensitive reaction/transmission reaction, including anaphylactic reaction, has been reported when using glucose solution (see side effects). Therefore, the solution containing glucose should be used carefully in all patients who are known to have hypersensitivity to corn or corn products (see the contraindications).
Stop immediately if there are any signs or symptoms that suspect is of the progressive hypersensitivity reaction. Appropriate treatment measures must be conducted according to clinical indications.
Feeding syndrome
Restoration of severe malnutrition patients can lead to feeding syndrome, it is characterized by the change of potassium, phosphorus and magnesi into the cell because the patient becomes assimilated. Thiamine deficiency and water retention can also occur. Careful monitoring and slowly increasing the nutrition and overeating to prevent complications.
Pediatric patients
The transmission speed and transmission volume depend on the age, weight, clinical and metabolic condition of patients, simultaneous treatment, and should be decided by an experienced consultant in the treatment of intravenous fluid for pediatric patients.
When using the transmission, all the clamps on the intravenous line must be closed before removing the transmission ropes from the pump, or the pump interrupt. This is a request regardless of whether the line has a free -flowing device. Intravenous equipment and transmission equipment must be monitored regularly.
Issues related to blood sugar in pediatric patients
Babies - especially premature babies and have low birth weight - there is a high risk of lowering or hyperglycemia and therefore closely monitoring when treating with 5% intravenous glucose solution to ensure adequate blood sugar control, to avoid unwanted long -term effects. Hypoglycemia in infants can cause prolonged seizures, coma and brain damage. Hyperglycemia may be accompanied by cerebral hemorrhage, bacterial and fungal infections, retinopathy in premature babies, necrotic bowelitis, bronchitis, lungs, prolonged the time of hospitalization and death.
Issues related to blood hypoglycetia in pediatric patients
Children (including newborns and older children) are at risk of increased osmotic pressure decrease due to hypoglycemia as well as developing sodium hypoglycemia.
The concentration of electrolytes in plasma should be closely monitored in pediatric patients.
Quickly overcome the reduction of osmotic pressure caused by hypoglycemia (risk of severe neurological complications). Dosage, speed, and transmission time should be decided by an experienced consultant in the treatment of intravenous fluids in pediatric patients.
Used in elderly patients
When choosing the types of transmission solutions and volume/speed of transmission for elderly patients, it is necessary to consider that elderly patients in general are more likely to suffer from heart failure, kidney failure, liver failure, and other diseases or use medications simultaneously.
Blood
Glucose solution (Glucose solution does not have free electrolytes) should not be used simultaneously with before or after blood transfusions with the same transmission device, because hemolysis and red blood cells may occur.
Add other drugs or use an improper transmission technique that can cause the appearance of fever reactions due to the appearance of fever in the blood. In the case of harmful reactions, it is necessary to stop the infusion immediately.
Risk of gas congestion
Do not use equipment and tools in infusion to connect many times. Using so can lead to gas congestion due to the remaining air is drawn from equipment and tools in the infusion before connecting to the intravenous system.
Increase the pressure of intravenous solutions in devices and tools to increase the flow rate that can lead to gas congestion if the gas remains in devices and tools that are not completely removed before transmission.
Use a set of intravenous venous lines with ventilation holes in the position that can lead to gas congestion. Venous lines have ventilation with ventilation holes in the location that should not be used with plastic packaging.
The ability to drive and operate machinery

unknown.
Pregnancy

When an extra drug is used, the characteristics of the drug and the use of it during pregnancy must be considered separately. Intravenous glucose transmission to mothers during labor can lead to insulin production in the fetus, related to the risk of hyperglycemia in the fetus and and metabolic acidosis as well as sudden hypoglycemia in infants.
Glucose solution may be used during pregnancy. However, be careful when the glucose solution is used during labor.
Breastfeeding period

When a drug is used more, the characteristics of the drug and the use of it during breastfeeding must be considered separately. There is no adequate data on the use of glucose solution when breastfeeding. However, there is no warning of effects on breastfeeding women. Glucose solution has been used during breastfeeding.
Drug interaction

Both effects on the blood sugar of glucose 5% intravenously and its effects on water and electrolytes should be noted when using intravenous glucose in patients treated with other substances that affect blood sugar control, or fluid or electrolytes.
Concentrated with catecholamine and steroids reduces glucose absorption.
No interactive studies have been conducted.
Cavalry
Before adding any drug to the glucose solution to transfer, it must be checked to see if it is appropriate. The solution contains glucose and has a pH

Storage

Store in a dry place, with a temperature not exceeding 30 ° C.

Each bottle is only used once. The non -use part must be canceled. Aseptic solution, no fever.

Do not use if the bottle is leaked or the solution is not transparent.

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