A Ame Bismo OPV oral discharge reduces digestive disorders, anti -diarrhea (60ml)

Dosage form Box x 60ml
Specifications Bismuth subsalicylat
Ingredient OPV Pharmaceutical Joint Stock Company

Ingredient

Thành phần cho 15ml

Composition information	Content
Bismuth subsalicylat	525mg

Uses

indications

Ambismo drugs are indicated in the following cases:

Mitigate symptoms such as digestive disorders, indigestion, and nausea due to excessive eating. Diarrhea.

ATC code: A07b b.

Bismuth subsalicylate has antibacterial effects, directly protecting mucous membranes and neutralizing weak acids.

salicylate when absorbed into the intestinal wall has anti -inflammatory effects, reduces intestinal edema, reduces indigestion, anorexia during diarrhea.

The epidemic contains the Bismuth Subsalicylate, which creates a protective layer for the mucosa of the lower esophagus and a part of the stomach.

The limited studies on In Vitro have shown that Bismuth Subsalicylat has some anti -intestinal diseases such as Clostridium, Bacteroides, E. Coli, Salmonella Shigella, Campulobacter (Helicobacter) and Yersinia, but non -anti -anaerobic bacteria. There is no enough data to determine whether these findings have any related treatment results in patients using Bismuth Subsalicylat.

Bismuth Subsalicylate has anti -diarrhea effect not only by stimulating water absorption and electrolytes through the intestinal wall but also inhibits prostaglandin synthesis when hydrolyzed into salicylic acid (prostaglandin causing intestinal inflammation and increased bowel movement).

In addition, Bismuth Subsalicylate is connected to toxins created by E. coli.

Dynamic pharmacokinetics

After drinking, bismuth subsalicylate is almost completely hydrolyzed into bismuth and salicylic acid in the digestive tract. Therefore, the pharmacokinetics of Bismuth Subsalicylate after oral can be described by pharmacokinetics of bismuth and individual salicylic acid.

bismuth: less than 1% of bismuth from the dose of bismuth subsalicylate has been absorbed from the gastrointestinal tract into the circulatory system. Bismuth has been absorbed throughout the body.

Bismuth is highly linked to plasma proteins (> 90%). Bismuth has a diverse selling time with intermediate selling time of 5 - 11 days and the final sale time is 21 - 72 days. Bismuth excreted mainly through urinary tract and biliary tract with renal clearance of 50 ± 18 ml/min. The average blood bottom concentration of bismuth after 2 weeks takes 787 mg bismuth subsalicylate (3 chewing tablets) x 4 times daily in fasting conditions is 5.1 ± 3.1 ng/ml. In another study, the average blood bottom concentration of bismuth after 2 weeks of taking 525 mg Bismuth subsalicylate (in the form of a chaos) x 4 times daily is 5 ng/ml, with the highest value of 32 ng/mL.

Salicylic acid: more than 80% of salicylic acid is absorbed from willow bismuth subsalicylate chewing tablets. About 90% of salicylate acid binds to plasma proteins. The integral distribution is about 170 ml/kg of body weight. Salycilic acid is metabolized widely and about 10% is excreted in the form of unchanged urine. The metabolic clearance of salicylic acid is saturated; Therefore, non -linear pharmacokinetics have been observed in the doses of Bismuth Subsalicylat above 525 mg. The metabolic clearance of salicylic acid in women is lower than that of men. The final waste time of salicylic acid after taking the single dose of 525 mg bismuth subsalicylate is 2 - 5 hours. After 1 single dose of 525 mg bismuth subsalicylate, the average peak concentration in the plasma of salicylic acid is 13.1 ± 3.4 µg/ml in fasting conditions. The average concentration in the stable state of the salicylate total serum after 2 weeks of taking 525 mg bismuth subsalicylate x 4 times daily is 24 ng/ml, with the highest value of 70 µg/ml.

Before taking A Ame Bismo OPV oral discharge reduces digestive disorders, anti -diarrhea (60ml)

How to use

oral medication. Shake well before use. Use the attached cup attached in the drug box.

Dosage

Adults and children over 16 years old: 15 ml/time. It is possible to repeat the dose per 2 - 1 hour if needed, up to 8 doses in 24 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

How to handle: Causes vomiting or gastrointestinal, using activated carbon. Transfusion, dialysis, peritoneal or blood transfusion is necessary for serious overdose cases. Monitor Salicylate concentration in serum until the concentration of drug decreases below the poisoning level. Monitoring and treating the survival functions, monitoring the phenomenon of pulmonary edema and convulsions for appropriate treatment.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Ambismo, you may experience unwanted effects (ADR) such as:

Common, ADR> 1/100: Black dyeing or tongue, discoloring tooth discoloration (recovery).

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

AMEBISBO drug contraindicated in the following cases:

Hypersensitivity to any ingredient of the drug. Hypersensitivity to aspirin or NSAIDs. Children under 16 years old.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Not used with aspirin or other Salicylate drugs.

Do not use Ambismo for children under 16 years of age because it can cause Reye syndrome, although the possibility of this syndrome is very rare, but the disease is extremely serious.

Be careful when used for patients with coagulation disorders or gout or patients who are taking anticoagulants, diabetes, gout.

Do not use if symptoms become worse or last more than 2 days.

For patients with diarrhea, especially in sick and elderly patients, they may be dehydrated and electrolyte. In these cases, the most important measure is to treat by rehydration and electricity. Do not use the recommended overdose. Do not take the drug for more than two days unless the doctor's prescription is prescribed. Use higher doses recommended or for a long time related to increased risk of unwanted effects (notably bismuth poisoning).

This drug contains: Ponaceau 4R, which can cause allergic reactions.

The effect of the drug on driving and operating machinery

No report.

Use drugs for women during pregnancy and lactation

Pregnancy and lactation period: There is no sufficient data on the use of Bismuth Subsalicylat for pregnant women. Animal studies are not enough to reflect the effects of pregnancy, embryo/fetal development, birth and postpartum development. The potential risk in people is unknown. Do not use Ambismo for pregnant and breastfeeding women unless really necessary.

Interactive drug

Ambismo contains salicylat, so it is necessary to be cautious when used if you are taking blood thinning (anti -pile of blood) or oral diabetes treatment or gout treatment, arthritis treatment.

Ambismo contains bismuth, which can reduce the absorption of tetracyclin antibiotics.

can minimize this interaction by taking these two drugs a few hours apart.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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