ABBSin 600 effervescent tablets in respiratory diseases with mucus (20 tablets)

Dosage form Effervescent tablet
Specifications Tube 20 tablets
Ingredient Acetylcysteine
Indication Cough with phlegm, acute bronchitis, chronic bronchitis
Contraindication Bronchial asthma

Ingredient

Composition information	Content
Acetylcysteine	600mg

Uses

indications

Absin drugs that prescribe mucus in respiratory diseases with mucus as in acute and chronic bronchitis.

Pharmacokic

Acetylcystein (N-acetylcystein) is the N-acetyl derivative of L-Cystein, a natural amino acid. Used as mucus and antidote when paracetamol overdose. Acetylcystein has the effect of elaborate to reduce mucus by sulhydryl that reduces the slope of the phlegm in the pus or not by separating the disulfua bridge in mucoprotein and creates favorable conditions to expel phlegm out when coughing, running posture or by mechanical method. This effect is the strongest at pH 7 - 9 and is not affected by DNA.

Acetylcystein is used as a liver antidote when paracetamol overdose and the exact mechanism of protective effects for the liver are not fully known. In vitro and animal research shows that a amount of paracetamol is metabolized by cytochrom P450 enzyme to form toxic intermediate metabolites (N-acetyl-P-Benzoquinoneimin, N-acetylimidoquinon, NAPQI) that cause liver cell necrosis, these substances are continued to be metabolized by interconnected in glutathion to be deducted in urine.

In the overdose of paracetamol can cause glutathion deficiency and thus reduces the inactivity of this toxic intermediate metabolite, and the metabolic line with glucuronic acid and sulfuric acid complex becomes saturated. Acetylcysteine has the effect of protecting the liver because it has maintained or restored the liver glutathion concentration that is essential to cause the active substance to metabolize the intermediate metabolism of paracetamol toxic to the liver or as a substrate for the combination of toxic intermediate metabolites.

Acetylcystein has the best liver protection if used within 8 hours after paracetamol overdose and may work after 24 hours. Clinical studies show that, when taking acetycystein, the drug concentration in the liver is higher than when intravenously but often causes vomiting. An anti -vomiting drug may be used.

Acetylcystein accurate mechanisms can prevent kidney poisoning due to unknown contrast drugs. Kidney poisoning may be caused by contrast drugs related to the formation of oxygen activity or related to reducing the activity of antioxidants; Acetylcysteine is an antioxidant containing thiol so it can reduce the ability to harm cells of free oxygen radicals arising.

In addition, the drug increases the biological effects of nitrogen oxyd by combining with oxyd to form S-nitrosothiol is a strong vasodilator. Interaction between acetylcystein and nitrogen oxyd can limit the production of peroxinitrate causing damage because acetylcystein competes with Superoxyd root to occupy nitrogen oxyd. However, the research figures were not enough to make an accurate conclusion about the effectiveness of acetylcysteine in the appointment of renal function decline due to contrast use.

pharmacokinetics

After drinking, Acetylcystein is quickly absorbed in the digestive tract and being reduced by Acetyl into cysteine and then metabolized, reaching the plasma peak concentration for about 0.5 to 1 hour after drinking the dose of 200 to 600 mg. Born when drinking is low and may be due to metabolism in the intestine and initially metabolic in the liver. 83% of the drug is attached to plasma. Kidney clearance can account for 30% of the whole body clearance.

Before taking ABBSin 600 effervescent tablets in respiratory diseases with mucus (20 tablets)

How to use

Dissolve Abbsin effervescent tablets with a cup of water and drink immediately.

Dosage

Dosage recommended: Take 1 capsule/day/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Other symptoms include respiratory failure, hemolysis, scattered blood clotting and kidney failure. Treatment of overdose as symptoms.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Acetylcysteine has a large safety limit. Although rarely clinically bronchospasm in clinical due to acetylcysteine, it can still occur with all types of drugs containing acetylcysteine.

Common, ADR> 1/100:

Digestive: Nausea, vomiting.

Neurological: Drowsy, headache, tinnitus.

Systemic: Bronchospasm with anaphylactic reaction, fever, chilling.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ABBSin is contraindicated in the following cases:

History of bronchial asthma (the risk of bronchospasm with all types of drugs containing acetylcysteine).

Prisable when using

must closely monitor patients at risk of asthma attacks, if using acetylcystein for people with a history of allergies, if there is bronchodious spasm, use bronchodilator spraying such as salbutamol (such as Beta-2 adrenergic selective, short effect) or ipratropium (antiviral medicine) Acetylcystein now.

When treated with acetylcystein, there may be a lot of diluted phlegm in the bronchi, need to be smoked to remove if the patient reduces cough.

Anaphylaxis leads to death when using acetylcystein has been reported, usually occurring for 30 - 60 minutes, need to monitor and stop the drug if the reaction occurs and timely treatment.

Be cautious when using the drug for patients, the diet must limit sodium because the drug has a sodium equivalent to about 403 mg of sodium.

Be cautious when using acetylcysteine in people with stomach ulcers, duodenum.

Use drugs for women during pregnancy and lactation

Pregnant women

Animal studies do not show any direct or indirect effects on reproductive toxicity. However, still cautious and avoid drugs during pregnancy.

breastfeeding women

Currently there is no enough data on whether acetylcysteine will be secreted into breast milk. It does not exclude the possibility that the drug can be toxic to babies/children.

The effect of the drug on the ability to drive and operate machinery

The drug can cause drowsiness, headache, so be careful for people who are driving and operating machinery.

Medicinal interaction

acetylcysteine is a reducing agent so it is not suitable for oxidants.

Do not simultaneously use other cough pills or any drugs that reduce bronchial secretion during acetylcysteine treatment.

Acetylcystein reacts with some metals, especially iron, nickel, copper and rubber.

Sodium acetylcystein solution is similar to chemical chemistry with solutions containing penicillin, oxacilin, oleandomycin, amphotericin B, tetracyclin, erythromycin lactobionate, or sodium ampicillin. When using one of the antibiotics in the form of aerosol, the drug must be sprayed separately. Acetylcysteine solution is also compatible with Physics with iodine, trypsin and hydrogen peroxyd.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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