Acarbose 50 Savi Treatment of diabetes (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Acarboose
Ingredient Savi Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Acarboose	50mg

Uses

Indications

Acarboose 50 drugs are indicated in the following cases:

Single therapy: As an auxiliary diet and exercise to treat type 2 diabetes (regardless of insulin) in people with hyperlemia (especially blood glucose after eating) uncontrolled only by diet and exercise.

Coordinate with sulfonylurea as an auxiliary diet and exercise to treat Type 2 diabetes. In patients with hyperlemen blood glucose uncontrolled by acarboose or Sulfonylura used alone.

Pharmacokic

Acarbose is a tetrasacharid anti -diabetes, inhibit alpha enzyme - Glucosidase, especially sucrase, slow digestion and absorption of carbohydrates. As a result, blood glucose increases more slowly after eating, reducing the risk of hyperlem of blood glucose, and the concentration of blood glucose is less fluctuating.

When using one -drug therapy, acarboose reduces the average concentration of hemoglobin glycosylate (about 0.6 to 1%). Reducing hemoglobin glycosylate is correlated with reducing the risk of microchip complications in diabetes. Acarbose does not inhibit enamel lactase and does not cause lactose intolerance.

contrary to the anti -diabetes drugs Sulfonylurea, acarbose does not increase insulin secretion. Acarbose also does not cause reducing blood glucose when they are hungry when used for monomers in humans. Because the mechanism of action of acarboose and anti -diabetes drugs Sulfonylurea varies, they have a combination effect when used in combination, acarbose also reduces weight gain and reduces the effects towards insulin of sulfonylurea.

However, because acarbose mainly slows than preventing glucose absorption, the drug does not lose many calories in clinical and does not cause weight loss in both normal people and diabetes. Acarbose can be added to help improve blood glucose control in patients treating t results with conventional therapies.

Dynamic pharmacokinetics

Normally, poor absorption drugs in the gastrointestinal tract, biological use

Due to poor absorption through the gastrointestinal tract and metabolized in the intestine, the carbose's dynamics is not changed the elderly, kidney failure or liver failure. Pre -clinical safety data: There is no new clinical safety data, in addition to the information in a summary of drug properties.

Before taking Acarbose 50 Savi Treatment of diabetes (10 blisters x 10 tablets)

This drug is only used as prescribed by a doctor.

How to use

Take oral use.

Take Acarbose at the beginning of the meal to reduce blood glucose concentration after eating.

The right dose is adjusted by the physician to suit each case, because of the effect and tolerance varies depending on the patient.

The pill must chew with the first piece of food or swallow the whole tablet with some water right before eating. There is no limitation of the time to use the drug. The goal of treatment is to reduce blood glucose after eating and hemoglobin glycosylate to normal or near normal with the lowest acarbo

During the initial treatment and adjust the dose to quantify glucose an hour after eating to determine the treatment response and the minimum dose the effect of acarboose. Then monitor hemoglobin glycosilate, every 3 months (life time of red blood cells) to evaluate long -term blood glucose control.

Dosage

Initial doses are often used for adults: 25mg.

Every 4 - 8 weeks increase the dose until the level of glucose is reached after 1 hour as expected (less than 180mg/decilite) or a maximum dose of 50mg, 3 times daily (for patients weighing 60kg or lighter) or 100mg, 3 times daily (for patients who seriously over 60kg).

Maintenance dose is commonly used: 50 - 100mg, 3 times a day. Using the dose of 50mg, 3 times daily may have fewer side effects but still as effective as when using the dose.

What to do when overdose? Symptomatic treatment of digestive disorders (diarrhea). Avoid using carbohydrate drinks or foods for 4 to 6 days after an overdose.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Most of the unwanted effects are digestive.

Common, ADR> 1/100

Digestive: bloating, stool, diarrhea, nausea, abdominal distention and pain.

Uncommon, 1/1000

Liver: Abnormal liver function.

Skin: itching, foreigner.

Rare, ADR

Liver: jaundice, hepatitis.

Instructions on how to handle ADR

Unwanted digestive effects can be reduced as they continue to treat and only need to reduce the amount of sugar (sugarcane).

To minimize digestive side effects, it is advisable to start the lowest dose and increase until the desired results are achieved.

Do not use anti -acid drugs to treat these digestive side effects.

Warnings

Contraindications

Do not take acarbose for the following cases:

hypersensitivity to acarbose.

Pregnant or lactating women.

Inflammation of the intestinal infection, especially combined with ulcers.

Because the drug has the ability to create steam in the intestine, Sulfonylurea should not be used. However, because acarboose mainly slower for people who are prone to disease due to increased abdominal pressure (escape is to prevent glucose absorption, the drug does not lose much micro).

Cases of liver failure, increased liver enzymes.

Hypoglycemia.

diabetes diabetes.

Precautions when taking drugs

Because there are cases of liver enzyme increase, liver transaminase should be monitored during acarboose treatment. Blood glucose may occur when using acarbose simultaneously with an anti -diabetic drug Sulfonylurea or insulin. When treating blood glucose, oral glucose must be used without using micro -absorbing sucrose, glucose is not inhibited by acarboose.

Acarbo

Drug interaction

Treatment in combination with sulfonylurea as an auxiliary drug - while acarboose treatment, food -containing food (cane sugar) often causes abdominal discomfort or diarrhea due to increased carbohydrate fermentation in the colon.

Acarboose can hinder iron absorption or metabolism.

Because the mechanism of action of acarboose and anti -diabetes drugs Sulfonylurea or BiguanID varies, their effects on blood glucose control are resonant when used in combination. Concomitance should be avoided with anti -acid, cholestyramine drugs, adsorbent in the intestine and digestive enzymes because it can reduce the effect of acarboose.

Storage

In the dry place, the temperature does not exceed 30 ° C. Avoid light.

Expiry date: 36 months from the date of production.

to be out of reach of children. Read the instructions carefully before use. If you need more information, you can consult a doctor.

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