ACEGOI AGIMEXPHARM POWDER TREATMENT, CRIME, NOOD, NEO BLOOD, headache (30 packs x 3g)

Dosage form Dough
Specifications 30 package box
Ingredient Chlorpheniramin Maleat, sodium benzoate, paracetamol

Ingredient

Composition information	Content
Chlorpheniramin Maleat	2mg
Sodium benzoate	100mg
Paracetamol	325mg

Uses

indications

Acegoi oral powder is indicated for hot treatment, cough, runny nose, stuffy nose, headache.

Pharmacology

paracetamol: This active ingredient has an analgesic - antipyretic effect due to inhibition of prostaglandin synthesis. With treatment dose, paracetamol has little impact on the cardiovascular and respiratory system, does not work on platelets or bleeding time.

Clopheniramin: competes with histamines H1 receptors of cells acting in the digestive tract, blood vessels and respiratory tract. Clopheniramine Maleat interferes with the connection of histamine with H1 histamine receptors to the glands of the nasal mucosa, to the skin, to the respiratory system and the digestive system. The drug is also antagonistic of histamine on capillaries and large blood vessels leading to reduced permeability and edema.

sodium benzoate: Liquet fluid, which increases mucus secretion, protecting the mucosa against stimulants (mucus), dissolves and looses these agents and makes it easy to get out of the respiratory tract.

pharmacokinetics

paracetamol

Absorption: Paracetamol is easily absorbed through the gastrointestinal tract with peak concentration in plasma reaching about 30 to 60 minutes after drinking, t about 1.25 to 3 hours.

Distribution and metabolism: Quickly and uniformly in most body tissues. About 25% Paracetamol in the blood combined with plasma proteins and is metabolized by the liver's microsoma enzyme, a small part is enzyme cytochrome P450 N - hydroxy to form N - Acetyl - Benzoquinon IMin, a highly reactive mediator (these substances cause liver cell necrosis). This substance reacts with glutathion and activity is reduced. Using high -dose paracetamol will produce more N - Acetyl - Benzoquinon imin, glutathion will be exhausted, leading to liver necrosis.

Elimination: Most paracetamol is excreted in the urine (90% - 100% on the first day of the treatment dose), mainly in the form of associated with glucuronic acid.

Clopheniramin

absorption: quickly absorbed through the gastrointestinal tract with peak plasma concentrations achieved after 2-3 hours.

metabolism and elimination: metabolism in the liver. The family sold for about 24 hours. The drug is excreted in metabolic metabolic and Didesmethylchlorpheniramine. Tallly and faster absorption, faster clearance, and half -life shorter has been recorded in children than adults.

sodium benzoat

The natural changes in combination with sodium benzoate with glycine to form hippuric acid, this substance is excreted later. This elimination mechanism affects nearly 95% of sodium benzoate oral dose. The rest is thought to be associated with glycuronic acid.

Before taking ACEGOI AGIMEXPHARM POWDER TREATMENT, CRIME, NOOD, NEO BLOOD, headache (30 packs x 3g)

How to use

Acegoi oral powder is mixed with some water before use.

Dosage

Children:

From 1 - 2 years old: Take ¼ pack/time.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

The complications due to high doses have not been recorded. However, because the drug contains paracetamol and clopheniramin maleat, the overdose symptoms for each substance are as follows:

Paracetamol poisoning may be due to a single dose, or due to a large dose of paracetamol (e.g. 7.5 - 10g a day, for 1-2 days), or for long -term medication. The liver necrosis depends on the dose is the most serious toxic effect due to overdose and may cause death. Paracetamol overdose symptoms: nausea, vomiting, abdominal pain, cyanosis on the skin, mucosa and nails.

The overdose symptoms of Clopheniramin include sedation, inverse stimulation of TKTW, mental rebellion, seizure, apnea, convulsions, anti -secretion effects acetylcholin, hypertonic reaction and cardiovascular collapse, arrhythmia.

How to handle:

Stomach or vomiting with ipecacuanha syrup. It is possible to treat convulsions with intravenous diazepam or phenytoin intravenously. Treatment is mainly symptoms and supports life.

In case of an overdose, besides the general treatment measures, taking N-acetylcysteine may be required immediately.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Acegoi oral powder, it is common for unwanted effects (ADR) such as:

Causes slight drowsiness, dry mouth, dizziness.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acegoi oral powder contraindicated in the following cases:

Hypersensitivity to paracetamol or any other ingredient in the drug. paralysis.

Caution when using

Doctors need to warn patients on signs of serious skin reactions such as Steven-Johson syndrome (SJS), syndrome, toxic skin necrosis (Ten) or Lyell syndrome, acute non-acne pustular syndrome (AGEP).

This drug can cause slight nausea.

Prolonged treatment in high doses, can be toxic to the liver and kidneys.

Hypersensitivity reaction.

This drug contains lactose patients with rare genetic problems in galactose intolerance, lagl lactose deficiency or glucose-galactose abutments should not be used.

This drug contains aspartam as the source of phenylalanin. This substance can be harmful if you have urinary phenylketon (PKU).

Erythrosin Dye ingredients in the drug can cause sensitivity. Be careful if you have a history of allergy to color products.

This drug contains white sugar so cautious in diabetics.

The effect of the drug on the ability to drive and operate machinery

This drug can cause drowsiness, be careful when driving and operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

There is no data on drug use in pregnant women, should only use the drug if the benefits are superior to the risk.

breastfeeding women

This drug should be used cautiously during breastfeeding. Patients should find the advice of a medical expert before using the drug.

Interactive drug

Monoamine oxydase inhibitors prolonged and increased anti -secretion effect of acetylcholine of antihistamine drugs.

ethanol or sedatives can cause sleep that can increase the inhibition effect of TKTW of chlorpheniramin.

chlorpheniramine inhibits phenytion metabolism and can lead to phention poisoning.

Long -term drinking high -dose Paracetamol increases the anticoagulant effect of cooumarin and indoplasmic derivatives.

Causes serious antipyretics in patients with simultaneous use of phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver.

cholestyramin: The absorption of paracetamol is reduced when used with cholestyramin. Therefore, Cholestyramin should not be taken within an hour if the pain is needed.

metoclopramid and domperidon: The absorption of paracetamol increases when used with metoclopramid or domperidon. However, avoid simultaneous use.

Cavalry: Due to no studies on the correlation of the drug, do not mix this drug with other drugs.

Storage

temperatures below 30 degrees Celsius, avoid moisture and light.

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