Acemol 325mg Nadyphar antipyretic and analgesic (40 blisters x 10 tablets)

Dosage form Box of 40 blisters x 10 tablets
Specifications Acetaminophen
Ingredient Fever, colds, headache, migraine, body aches, teething

Ingredient

Composition information	Content
Acetaminophen	325mg

Uses

indications

Acemol drugs are indicated for antipyretic and analgesic treatment in the following cases: flu, fever, aches and pains.

Pharmacokology

Paracetamol (acetaminophen or N-acetyl-P-Aminophenol) is an active metabolic substance of phenacetin, an effective antipyretic analgesic that can replace Aspirin. However, unlike aspirin, paracetamol is not effective in treating inflammation. With the equal dose calculated by grams, paracetamol has an analgesic and antipyretic effect similar to Aspirin.

paracetamol reduces the body temperature in fever, but rarely reduces the body temperature in normal people. The drug affects the hypothalamus causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

Paracetamol with treatment dose, less impact on the cardiovascular system and steaming, does not change the balance of acid-base, does not cause irritation, scratches or stomach bleeding because paracetamol does not work on body cyclooxygenase, only affects cyclooxygenase and prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

Pharmacokinetics

absorption

The type of oral medication is completely absorbed. The drug is weak with plasma protein to reach a maximum concentration after 30-60 minutes.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism, excretion

Semi -destructed time in plasma from 1.25 hours to 3 hours. Paracetamol metabolizes in the liver, eliminated in the urine in the form of: combined with glucuronic acid (about 60%), sulfuric acid (about 35%), or cysteine (about 3%) and a small amount of hydroxyl metabolites - chemicals and reducing acetyl. Paracetamol is converted under the effect of cytochrom P450 into metabolic and is quickly reduced by glutathion. Poisoning caused by this metabolite increases when high doses.

Before taking Acemol 325mg Nadyphar antipyretic and analgesic (40 blisters x 10 tablets)

How to use

oral medication.

Dosage

According to the instructions of the physician, average:

Adults

Take 1-2 tablets each time, 3 times a day or 4 hours.

Children over 12 years

Each time taking 1 tablet, 2-3 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

Paracetamol poisoning may be due to a single -dose, or due to a large dose of paracetamol (7.5 - 10 g in 1-2 days) or for long -term medication. The liver necrosis depends on the dose is the most important toxic effect due to overdose and can be fatal. When an overdose of paracetamol, a metabolic substance is N-acetyl benzoquinonimin that is toxic to the liver.

Excessive dose can cause liver cell decomposition, metabolic acidosis, brain pathology leading to coma, death.

Handling overdose

Gastric lavage (preferably within 4 hours after drinking).

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the supplementation of glutathion reserves in the liver, N-acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with n-acetylcysteine is more effective when giving the drug for less than 10 hours after taking paracetamol.

When drinking, dilute N-acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N-acetylcystein oral at the first dose of 140 mg/kg, then give 17 more doses, each dose of 70 mg/kg every 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

Can use methionin, activated carbon and/or salt bleach because they have the ability to reduce paracetamol absorption.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using acemol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

Skin: A few cases of allergies: skin rash with roses or urticaria.

digestive: digestive disorders. blood: neutrophils, anemia.

Urinary: Poison with kidneys.

Rare, ADR

Blood: platelets.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Acemol drugs contraindicated in the following cases:

Hypersensitivity to paracetamol.

Lack of glucose-6-phosphate dehydrogenase (G6PD).

Be cautious when using

patients with anemia before. Impaired liver or kidney function.

Drinking plenty of alcohol can increase the toxicity of paracetamol to the liver.

Doctors need to warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

used for pregnant women.

breastfeeding period

Used for nursing women.

Medicinal interaction

Concentrated with anti -seizures (phenytoin, barbiturat, carbamazepin), isoniazid increases the toxicity of the liver.

Long -doses of high -dose Paracetamol increases the anti -dynamic effect of COMAARIN and indoplasm. This effect is small or not clinically important, so paracetamol is used when it is necessary to relieve mild pain or reduce fever for patients who are using Coumarin and indandion.

Storage

Store at a temperature not exceeding 30 ° C, in a dry place.

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