Acemol 325mg Nadyphar antipyretic and analgesic (40 tablets)

Dosage form Tablet
Specifications Paracetamol
Ingredient Body aches

Ingredient

Composition informationContent
Paracetamol325mg

Uses

Indications

Acemol 325 mg is indicated in the following cases:

  • Antipator of fever and analgesic in the following cases: colds , fever, aches and pains. Aspirin; However, unlike aspirin, paracetamol is not effective in treating inflammation.

    With the equal dose calculated by grams, paracetamol has analgesic and fever -reducing effect similar to aspirin.

    paracetamol reduces body temperature in fever, but rarely reduce body temperature in normal people. The drug affects the hypothalamus causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

    Paracetamol with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding because paracetamol does not work on the body cyclooxygenase, only affects cycloxygenase and prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

    pharmacokinetics

    The type of oral oral drug is completely absorbed.

    Linking drugs with plasma proteins reach a maximum concentration after 30-60 minutes. Paracetamol is quickly and evenly distributed in most body tissues. About 25% paracetamol in the blood combined with plasma proteins. Selling time in plasma from 1.25 hours to 3 hours.

    Paracetamol is metabolized under the effect of cytochrome P450 into metabolic and is quickly reduced by glutathion. Poisoning caused by this metabolite increases when high doses.

    paracetamol metabolizes in the liver, excreted in the urine in the form of: combined with glucuronic acid (about 60%), sulfuric acid (about 35%), or cysteine ​​(about 3%) and a small amount of hydroxylation and reducing substances.

    • Before taking Acemol 325mg Nadyphar antipyretic and analgesic (40 tablets)

    How to use

    ACEMOL drugs are taken orally.

    Dosage

    Following the instructions of the physician, on average:

  • Adults: 1-2 tablets each time, 3 times a day or 4 hours. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? The liver necrosis depends on the dose is the most important toxic effect due to overdose and can be fatal. When using paracetamol overdose, a metabolic substance is N - acetylbenzoquinonimin, which is toxic to the liver.

    Excessive dose can cause liver cell decomposition, metabolic acidosis, brain pathology leading to coma, death.

    Overdose treatment: gastric lavage (preferably within 4 hours after drinking). The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the supplement of glutathion reserves in the liver, N - acetylcystein, which works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcysteine ​​is more effective when giving the drug for less than 10 hours after taking paracetamol.

    When given, dilute N - Acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcysteine ​​at the first dose of 140 mg/kg, then give 17 more doses, each dose of 70 mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

    Can use methionin, activated carbon and/or salt bleach because they have the ability to reduce paracetamol absorption.

    What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    • Side Effects

    When using Acemol 325 mg, you may experience unwanted effects (ADR).

    Do not determine the frequency ADR:

  • Digestive: digestive disorders .
    • Hematology: Neutral leukopenia, anemia, rarely platelets.

    Other: allergies, skin rashes with roses or urticaria, toxic to kidneys.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Acemol 325 drug is contraindicated in the following cases:

  • Hypersensitivity to paracetamol.
  • Lack of glucose - 6 - Phosphate dehydrogenase (G6PD).

    • Precautions when used

    Anemia patients before. Impaired liver or kidney function.

    Drinking plenty of alcohol can increase the toxicity of paracetamol for the liver.

    Doctors need to warn the patient about signs of serious skin reactions such as Steven - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

    The ability to drive and operate machinery

    The drug does not affect the ability to drive and operate machinery

    Pregnancy

    Used for pregnant and lactating women.

    Breastfeeding period

    Used for pregnant and lactating women.

    Medicinal interaction

    Simultaneously used with anti -seizures (phenytoin, barbiturat, carbamazepin ), Isoniazid increases the toxicity of the liver.

    Long -doses of high -dose Paracetamol increases the anticoagulant effects of cooumarin and indoors. This effect is small or not clinically important, so paracetamol is used when it is necessary to relieve mild pain or reduce fever for patients who are using Coumarin and indandion.

    Storage

    At a temperature not exceeding 30 ° C, in a dry place.

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