Acetab Extra Agimexpharm Treatment of flu symptoms (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol, caffeine
Indication Fever, headache, muscle pain, sore throat
Contraindication Drug allergy

Ingredient

Composition information	Content
Paracetamol	500mg
Caffeine	65mg

Uses

Indications

Acetab Extra indicated to treat flu symptoms: headache, fever, sore throat, muscle aches.

Pharmacokology

related to paracetamol

Paracetamol (acetaminophen or N-acetyl-P-P-Aminophenol) is a metabolic substance that has the activity of phenacetin, an effective analgesic-antipyretic.

Paracetamol is used temporarily in the treatment of mild and medium pain. The most effective drug is to reduce low intensity pain from non -internal organs.

paracetamol reduces the body temperature in fever, but rarely reduces the body temperature in normal people. The drug affects the hypothalamus causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

With the dose of drug treatment less impact on the cardiovascular and respiratory system, does not cause stomach irritation, does not work on plateletic collection or bleeding time.

When an overdose of paracetamol, a metabolic substance is N-acetyl-benzoquinonimin that is toxic to the liver.

related to caffeine

Cafeine is the derivative of xanthin (methylxanthin) that stimulates the central nervous system, helps to alert, increases mental activity, supports pain relief and makes it easy for muscle activity.

With a dose of 65 mg, caffeine is used as a mild mediocre nerve stimulant enhances Paracetamol pain relief effect.

pharmacokinetics

related to paracetamol

absorption:

fast and almost entirely through the digestive tract. Achieving a peak concentration of 30 - 60 minutes after drinking with treatment dose.

Distribution:

fast and uniform in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism:

Paracetamol is n - hydroxylated by cytochrom P45O to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus deducted activity.

However, if you take high doses of paracetamol, this metabolite is formed in sufficient amount to exhaust the liver's glutathion, in that situation, N-acetyl-Benzoquinonimin is not in combination with toxic glutathion for liver cells, leading to inflammation and can lead to liver cell necrosis.

Era:

The half -life of Paracetamol plasma is 1.25 - 3 hours. Most of the urine elimination (90% - 100% of the first day of treatment), mainly in the form of glucuronic acid.

related to caffeine

Cafeine is absorbed quickly and completely after drinking. The maximum concentration in plasma is achieved within 1 hour. Cafeine is widely distributed throughout the body, through the central nervous system and through saliva. Cafein is also present in low concentrations and also crosses the placenta.

Cafe waste time is about 3-7 hours. Caffeine is metabolized almost entirely in the liver with oxidation, reduction of methyl and acetylation; Then excreted in the urine in the form of metabolites, only about 1% of the dose is found in the form of constant urine.

Before taking Acetab Extra Agimexpharm Treatment of flu symptoms (10 blisters x 10 tablets)

How to use

Drugs used by oral, do not use this drug to treat pain for more than 10 days in adults, more than 5 days in children or self -treat high fever (over 39.5 ° C), fever lasting for more than 3 days, recurrent fever, unless the physician is instructed.

Dosage

Adults: Take 1-2 capsules/ time, 3-4 times/ day (maximum 8 tablets/ 24 hours). The distance between the doses is at least 4 hours.

Children:

Children from 12 years old - 16 years old: take 1 tablet/ time.

Children from 16 years old - 18 years old: take 1-2 capsules/ time.

Doses for children can repeat after 4 - 6 hours if necessary, no more than 4 times/ 24 hours.

Not recommended for children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

If any overdose symptoms occur as the following manifestations, the patient stopped taking the medication immediately and notified the doctor or went to the medical facility immediately.

Related to paracetamol:

Nausea, vomiting, and abdominal pain usually occur within 2-3 hours after taking the poisonous dose of the drug. Blood methemoglobin causes purple blue, mucous membranes, nails.

The liver necrosis depends on the dose is the most serious toxic effect due to overdose and can cause death.

Related to caffeine:

There are symptoms of epigastric pain, vomiting, excretion, tachycardia, arrhythmia, central nervous stimulation (insomnia, restlessness, tremor, convulsions, ...)

Management

Paracetamol overdose: Early diagnosis is important in the treatment of paracetamol overdose. When severe poisoning, it is important to treat positive support. Need to wash the stomach in any case, preferably within 4 hours after drinking.

Use antidote: n-acetylcystein, methionin.

Also can use activated carbon to reduce drug absorption.

Cafe overdose: No specific detoxification but can use supportive treatments.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Acetab Extra has little side effects when used with doses and recommendations, but some unwanted effects may occur as follows:

Related to paracetamol

Paracetamol sensitive reactions with redness on skin recovery or blood disorders may occur, although rare. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. If you see a fever, bullies around the natural cavities, you should think of Stevens-Johnson syndrome, to stop the drug immediately.

If the dose is higher than the recommended dose can cause serious liver damage.

Patients with liver and kidney failure must be monitored by a doctor when using drugs containing paracetamol.

Related to caffeine

Insomnia, fatigue, dizziness, suspense, digestive disorders. Long -term use causes drug tolerance, when stopping the drug suddenly can cause irritation, restlessness, lethargy, headache ...

When patients use drugs in combination with daily amount of coffee, they can increase the adverse adverse reaction related to caffeine such as insomnia, awake, anxiety, stimulation, headache, gastric disorders and fast heartbeat.

When experiencing side effects of the drug, patients need to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acetab Extra is contraindicated in the following cases:

Hypersensitivity to paracetamol, caffeine or any ingredients of the drug.

Caution when using

Conditions need to be cautious

Doctors need to warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

Paracetamol is relatively non -toxic to treatment. Sometimes there are skin reactions including itchy and urticaria, other sensitive reactions including laryngeal edema, angioedema and anaphylactic reactions that can rarely occur. Platelets, leukopenia and all bloody hematuria have occurred with the use of p-aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Must take care of the drug in:

Patients with anemia before, because purple blue may not manifest, although there are dangerous high concentrations of methemoglobin in the blood.

People with heart disease, lungs, kidney failure or liver failure.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Avoid using other drugs containing paracetamol.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol; Should avoid or limit drinking.

Because caffeine -containing drugs can cause central nervous irritation, insomnia if used in the evening.

Avoid using too much caffeine (for example, tea, coffee ...) while taking acetate drugs Extra.

The excipient of this drug has lactose so it should not be used for patients with Galactose intolerance, lactase deficiency or glucose-galactose.

Using drugs for women during pregnancy and lactation

Pregnancy:

Not determined the safety of paracetamol used during pregnancy is related to unwanted effects that may have for pregnancy development.

At the end of pregnancy, when taking high doses, caffeine can cause arrhythmia of the fetus and babies.

Combining paracetamol with caffeine is not recommended for women during pregnancy due to the risk of premature and light weight in infants. Do not use this drug in pregnant women.

Breastfeeding period:

Cafein can be affected by breastfeeding. Do not take this medicine in breastfeeding women.

The effect of drugs on driving and operating machinery

There is no information on the effect of the drug on driving and operating machinery.

Interactive drug

Do not use Acetab Extra at the same time with other drugs containing paracetamol, caffeine.

Long -term drinking high -dose Paracetamol increases the anticoagulant effect of cooumarin and indoplasmic derivatives.

It is necessary to pay attention to the likelihood of causing serious hypothermia in patients with simultaneously phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver.

In addition, simultaneous use of isoniazid with paracetamol can also lead to an increased risk of toxicity to the liver, but it has not yet been determined the exact mechanism of this interaction.

Increasing paracetamol absorption speed when used with metoclopramid or domperidon.

Paracetamol reduces absorption when used simultaneously with cholestyramin, so it should not be taken cholestyramin within 1 hour if it is necessary to minimize pain.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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