Acigmentin 625 Minh Hai medicine for severe respiratory infections (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Skin and soft tissue infections, acute bronchitis, upper respiratory tract infections, chronic bronchitis, pneumonia, osteoarthritis

Ingredient

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Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

Indications

Acigmentin 625mg drugs are indicated in the following cases:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media injury. Lactam has broad bactericidal spectrum for many Gram -positive and gram -negative bacteria due to the synthesis of bacterial cell walls. But because Amoxicilin is easily destroyed by beta - lactamase, so Amoxicillin does not work for bacterial strains that produce these enzymes. Clavulanic acid has a beta -lactam structure similar to penicillin that has the ability to inhibit beta - lactamase due to the majority of Gram -negative and staphylococcus bacteria. In particular, clavulanic acid has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins.

The combination of clavulanic acid and amoxicillin helps Amoxicillin not to be destroyed by beta - lactamase, and expand the antibacterial spectrum of amoxicillin effectively to many common bacteria, have resisted amoxicillin, resist other penicilins and cephalosporins.

pharmacokinetic

amoxicillin and clavulanic acid both absorbed easily by oral. Maximum concentration in serum after 1-2 hours. The absorption of the drug is not affected by food and it is best to drink right before the meal. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%. Amoxicillin waste time in serum is 1 to 2 hours and of clavulanic acid is about 1 hour. 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Acigmentin 625 Minh Hai medicine for severe respiratory infections (2 blisters x 7 tablets)

How to use

Oral drugs, should take the drug at the beginning of the meal to minimize the phenomenon of non -tolerant drugs in the stomach - intestines.

Dosage

for adults and children ≥ 12 years:

Mild and medium infections: 1 tablet 12 hours/1 time.

Severe infections: 1 tablet 8 hours/1 time.

Treatment must not exceed 14 days without examination.

Patients with renal failure

Adult dose

Creatinine clearance

Dose

from 10 - 30ml/minute

No dose adjustment.

Initial dose 1g, then every 12 hours of injection 500mg.

Initial dose 1g, then 500mg/day.

Creatinine clearance

Dose

from 10 - 30ml/minute

No dose adjustment.

25mg/kg, 2 times daily.

25mg/kg/day.

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case the kidney function decreases and the barrier - the brain is poor. However, general reactions occur depending on the hypersensitivity of each individual. The risk is definitely increased by potassium when taking very high doses because clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using acigmentin 625, you may experience unwanted effects (ADR).

Common

diarrhea, foreign rash, itching.

Less:

Incretion increases, nausea, vomiting, hepatitis and jaundice, transaminase increases, can be severe and lasting for a few months, itching, erythema, rash.

Rare:

Anaphylaxis reactions, Quincke edema, platelet mitigation, leukopenia, hemolytic anemia, fake colitis, Stevens - Johnson syndrome, diverse erythema, peeling inflammation, epidermal necrosis due to poisoning, interstitial nephritis.

Instructions on how to handle ADR:

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acigmentin 625mg contraindicated drug in the following cases:

allergies to the beta - lactam group (penicillin and cephalosporin). Pay attention to patients with a history of jaundice/liver dysfunction due to the use of amoxicillin and clavulanate or penicillin because clavulanic acid causes increased cholestatic risk in the liver.

Precautions when using

for patients with signs of liver dysfunction.

Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, those symptoms are often recovered and will end after 6 weeks of treatment.

For people with average or severe renal impairment, attention should be paid to the dosage.

For patients with a history of hypersensitivity to penicillins that can react severe or death.

For those who use amoxicillin with redness with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Note for people with phenylceton - urinary because the problems contain 12.5mg of aspartam in 5ml. When high -dose intravenous injection, it is necessary to maintain the balance of import and export fluid to minimize the phenomenon of stones - ureter. The bladder pipes must be checked regularly to avoid precipitation causing clogged when there is a high concentration of preparations in the urine at normal temperature.

The ability to drive and operate machinery

No records.

Pregnancy

Experimental research on the reproductive process of mice proved when using oral preparations and injections are not deformed. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

Breastfeeding period

During breastfeeding can use preparations. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Medicinal interaction

The drug can cause prolonged bleeding time and blood clotting. Therefore, it is necessary to be careful for those who are treated with anticoagulants.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient in advance.

Storage

temperature below 30 ° C. Cool dry place, avoid light.

To be out of reach of children.

Other drugs

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