ACMEIGEL Medipharco gel treat pustules, skin infections (15g)

Dosage form Tube x 15g
Specifications Metronidazol

Ingredient

Thành phần cho 15g

Composition information	Content
Metronidazol	0.15g

Uses

Indications

Gelacmeigel gel gel is indicated for topical treatment for inflammatory lesions in red acne.

Pharmacokology

ATC code: d06bx01.

Metronidazol is a 5-nitro-in-idazol derivative, with a broad activity spectrum. Metronidazole has antibacterial activity on bacteroides spp., Fusobacterium and anaerobic bacteria, but does not work on aerobic bacteria.

Rare drug resistance for metronidazol or only in the case of high doses for a long time. Metronidazole has anti -inflammatory effects with not yet clear mechanism.

Dynamic pharmacokinetics

After taking 1 gram of gelacmeigel gelacmeigel applied on the facial skin of 13 patients with severe red acne a day once a day in 7 days, the average metronidazole concentration in plasma reaches 32 ± 9 nanogam/ml.

The average value of the area under the AUC curve (0-24) reaches 595 ± 154 ng*HR/mL.

The average values of CMAX and AUC (0-24) are 1% lower than that of the values reported for the only 250 mg oral dose of Metronidazole. The time for the drug to reach the maximum concentration in plasma (TMAX) is 6 - 10 hours after applying.

Before taking ACMEIGEL Medipharco gel treat pustules, skin infections (15g)

How to use

Gel -like pills used on the skin.

Should wash the skin to be treated before taking Gelacmeigel Gelacmeigel, apply a thin layer of gelacmeigel gelacmegel to the damaged skin.

After applying Gelacmeigel GelacmeGel, cosmetics can be used.

Do not use oral, ophthalmology or vaginal application.

Dosage

Apply a thin layer of gelacmeigel gelacmegel to the damaged skin, once a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: There is no specific treatment. Stop taking medicine.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using gelacmeigel skin gel, you may experience unwanted effects (ADR) such as:

frequency Side effects worsening status of red acne.

In addition, it can cause skin swelling (because the ingredient contains dozens of glycol propylene).

Unknown contact dermatitis

nervous nausea

Instructions on how to handle ADR:

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

gelacmeigel contraindicated in the following cases:

Patients with hypersensitivity to metronidazol derivatives or any ingredients in the formula.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Neurological pathology: peripheral neuropathy, characterized by loss of sensation or numbness, has been reported in some patients treated with systemic metronidazol, although there is not enough clinical trials for locally used metronidazol, peripheral neuropathy has reported after use in patients. If there are nerve abnormal signs, gelacmeigel treatment should be reviewed. Metronidazole should be used cautiously in patients with central neurological diseases.

Dehydration: Metronidazole is a nitroimidazole, which is carefully used in patients with signs of or a history of blood disorders.

Exposure dermatitis: There is a report on allergic contact dermatitis when taking the drug. If allergic dermatitis occurs, patients need to stop using the drug.

Eye irritation: Metronidazole topical used in place has been reported to cause tears. Avoid exposure to eye.

In the ingredients containing excipients that can cause skin irritation such as propylene glycol can cause female swelling, methylparaben can cause allergic reactions.

The effect of drugs on driving and operating machinery

There is no report on side effects on the ability to drive or use machines after using Gelacmeigel.

Use drugs for women during pregnancy and lactation

pregnancy:

The safety of preparations containing Metronidazole is topical for skin during pregnancy that has not been fully proven and should not be used in these cases unless the doctor deemed necessary.

breastfeeding period:

After oral use, Metronidazol excreted quite quickly into breast milk, the concentration of drugs in the breastfeeding of the breastfeeding can be equal to 15% of the mother's plasma concentration. Although the concentration of blood in the blood when using Metronidazol preparations is significantly lower than the oral form, should stop breastfeeding during treatment with Metronidazol. It is necessary to consider the benefits of the drug on the mother and the risk of babies.

Drug interaction

gelacmeigel skin gel contains metronidazol, the drug has a local effect and is very few absorbed, so there is no notice of the drug's interaction when used with other drugs. However, it should be noted that drug interactions may occur in the following cases:

Metronidazole increases the effect of oral anticoagulants, especially warfarin, prolongs prothrombin time, so avoiding use at the same time. The effect of Metronidazol gel topical gel on the spot on the unknown prothrombin period. Therefore, do not use these two drugs simultaneously to avoid nervous effects such as psychosis, confusion.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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