Acnekyn 500mg Southeast treatment of pain and fever from mild to dysfunction (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Fever, body aches
Contraindication Acute renal failure, chronic kidney failure, liver failure

Ingredient

Composition information	Content
Acetaminophen	500mg

Uses

indications

Acnekyn 500 mg drug is indicated in the following cases:

Treatment of pain and fever from mild to medium. The most effective drug is to relieve low intensity pain from non -internal organs. Acetaminophen does not have the effect of treating rheumatism, is a Salicilate replacement to relieve pain or reduce fever. - Effective antipyretic can replace aspirin; However, unlike aspirin, acetaminophen has no effect on inflammation treatment. With equal dose calculated by grams, acetaminophen is used to reduce pain and reduce fever similar to aspirin.

Acetaminophen reduces body temperature in fever, but rarely reduces body temperature in normal people. The drug affects the hypothalamus causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

Acetaminophen with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like when using salicylat, because acetaminophen does not work on the whole body cyclooxygenase, only affect cycloxygenase/prostaglandin of central nervous system.

Acetaminophen does not work on platelets or bleeding time. When overdose of acetaminophen, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver. Normal doses, acetaminophen well tolerated, without many side effects of aspirin. However, acute overdose (over 10 g) causes liver damage to death, and the poisoning and suicide with acetaminophen has increased in a worrying manner in recent years. In addition, many people including physicians, seemingly unaware of the poor anti -inflammatory effects of acetaminophen.

Pharmacokinetics

absorption

Acetaminophen is quickly absorbed and almost completely through the gastrointestinal tract. Foods can make long -lasting release tablets Acetaminophen slowly absorbed in part and food rich in carbon hydrate reduces acetaminophen's absorption rate. The peak concentration of plasma is within 30 to 60 minutes after drinking with the dose of treatment.

Distribution

Acetaminophen is distributed quickly and evenly in most body tissues. About 25% acetaminophen in the blood combined with plasma proteins.

Elimination

Half of the plasma of acetaminophen is 1.25 - 3 hours, can last for toxic doses or in patients with liver damage.

After the dose of treatment, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); also detected a small amount of hydroxyl metabolites - chemical and reducing acetyl.

Children are less likely to glucuro than drugs than adults. Acetaminophen is N - hydroxylation by cytochrom P450 to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus is dedicated. However, if taking high doses of acetaminophen, this metabolite is formed in sufficient amount to exhaust the glutathion of the liver; In that situation, its reaction to the liver's sulfhydryl group increases, which can lead to liver necrosis.

Before taking Acnekyn 500mg Southeast treatment of pain and fever from mild to dysfunction (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults: The disposable oral dose of acetaminophen is 0.3 - 1.0 g, taken 3-4 times/day, must not exceed 4.0 g/day. The distance between use at least 4 to 6 hours.

Dosage may vary depending on the age and symptoms of the patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Expression

Acetaminophen poisoning may be due to a single -dose, or due to a large dose of acetaminophen (for example, 7.5 - 10 g per day, for 1-2 days), or for long -term medication. The liver necrosis depends on the dose is the most serious toxic effect due to overdose and may cause death. Nausea, vomiting, and abdominal pain usually occur within 2-3 hours after taking the poison of the drug.

Methemoglobin - Blood, leading to purple blue, mucous and nail is a sign of acute poisoning P - Aminophenol; A small amount of sulhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking acetaminophen.

When severe poisoning, it may initially stimulate the central nervous system, agitated, and delirium. Next can be inhibiting the central nervous system; Stunned, lower body temperature; tired; Breathing fast, shallow; fast, weak, uneven circuit; Low blood pressure; and circulatory failure. Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation.

Choking convulsions may occur. Often coma occurs before death suddenly or after a few days of coma. Clinical signs of liver lesions become clearly within 2 to 4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of bilirubin in plasma can also increase; In addition, when the liver lesions spread, the long prothrombin time.

may be 10% of patients with untreated poisoning that have serious liver damage; Among them 10% to 20% finally die from liver failure. Acute renal failure also occurs in some patients. The liver biopsy detects the central necrosis of the lobe except the area around the door vein. In cases of non -death, liver lesions recover after weeks or months.

Treatment

Early diagnosis is important in the treatment of overdose acetaminophen. When severe poisoning, it is important to treat positive support. Gastric lavage is needed in any case, preferably within 4 hours after drinking. The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver. N - Acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours of death when taking acetaminophen.

If there is no n - acetylcystein, methionine may be used. Also can use activated carbon and/or salt bleach, they have the ability to reduce acetaminophen absorption.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using 500 mg Acnekyners, you may experience unwanted effects (ADR).

Uncommon, 1/1000

DA: Ban.

stomach - intestines: nausea, vomiting. Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, 1/10000

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Acnekyn 500 mg contraindicated in the following cases:

Patients with anemia many times or heart, lung, kidney or liver disease.

Patients with hypersensitivity to acetaminophen.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Be cautious when using

acetaminophen is relatively non -toxic to the dose of treatment. Sometimes there are skin reactions including itching rash and day eyebrows; Other sensitive reactions include larynx edema, angioedema, and anaphylactic reactions that may rarely occur. Platelets, leukopenia, and all bloody hematuria have occurred with the use of p - aminophenol derivatives, especially when used for large doses. Neutral leukemia and thrombocytopenic hemorrhage occur when using acetaminophen. Rarely loss of granulocytes in patients using acetaminophen.

People with phenylceton - urinary (that is, gene deficiency determines the status of phenylalanin hydroxylase) and people must limit the amount of phenylalanin that must be warned as some acetaminophen preparations containing aspartam, which will transform in the stomach - intestinal citadel of phenylalanin after drinking.

Some types of acetaminophen drugs on the mayor containing sulfit may cause an allergic reaction, including anaphylaxis and life -threatening or less serious henses in some hypersensitivity people. It is unknown the general ratio of hypersensitivity to sulfit among the people in general, but it must be low; Such hypersensitivity seems to be more common in patients with asthma in humans without asthma.

Must use acetaminophen carefully in patients with anemia before, because purple blue may not show clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause increased toxicity to the liver of acetaminophen; Should avoid or limit drinking.

Use carefully with people with impaired liver or kidney function.

The ability to drive and operate machinery

has no significant effect.

Pregnancy

has not determined the safety of acetaminophen used during pregnancy related to unwanted effects that may have for pregnancy development. Therefore, only acetaminophen should only be used in pregnant people when needed.

Breastfeeding period

Research in mothers using acetaminophen after lactation, no unwanted effect in breastfeeding.

Drug interaction

long -term oral high doses of acetaminophen increases the anticoagulant effect of COMAARIN and indoplasm.

It is necessary to pay attention to the likelihood of serious antipyretics in patients to use simultaneously phenothiazine and cooling therapy.

Out of too much and long -term alcohol can increase the risk of acetaminophen toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of acetaminophen due to increased drug conversion into toxic substances to the liver.

In addition, simultaneous use of isoniazid with acetaminophen can also lead to an increased risk of toxicity to the liver, but it has not yet been determined the exact mechanism of this interaction. The risk of acetaminophen thin liver toxicity increases significantly in patients with acetaminophen -dose larger than the promotion dose while taking anti -convulsions or Isoniazid. often do not need to reduce the dose in patients with the same dose of acetaminophen treatment and anti -convulsions, however, patients must limit self -use acetaminophen while taking anti -convulsions or Isoniazid.

Storage

Store in a dry place, temperatures below 30 ° C, avoiding light.

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