Acnotin 10mg Mega We Care treatment for heavy acne (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Isotretinoin
Ingredient Acne

Ingredient

Composition information	Content
Isotretinoin	10mg

Uses

Indications

Acnotin drugs are indicated for treatment of severe acne (such as cystic acne, clustered acne or acne that is at risk of permanent scars) does not respond to conventional treatments for antibiotics and local drugs.

Pharmacokological

According to the current knowledge, Isotretine works to reduce sebaceous gland size and inhibit the activity of sebaceous glands, thus reducing sebum secretion. In addition, there is anti -inflammatory effect on the skin.

pharmacokinetics

isotretinoin is absorbed through the digestive tract. Drinking isotretinoin at meals can increase the bioavailability of the drug thanks to the absorption properties of the drug due to high lipid preference.

Isotretinoin is metabolized in the liver and may be in the small intestine wall. The main metabolites are found in the blood and urine as 4 - Oxo - Isotretinoin. There are also other substances such as isotretinoin and 4 - Oxo - Isotretinoin.

Isotretinoin is excreted mainly by the metabolism of the liver and excretion in bile. The average selling time for the drug has not metabolized is 19 hours, the average selling time for metabolites 4 - Oxo - Isotretinoin is 29 hours.

Before taking Acnotin 10mg Mega We Care treatment for heavy acne (3 blisters x 10 tablets)

How to use

Isotretinoin should only be prescribed by a doctor who has experience using heavy acne retinoids and fully understood the risk of isotretinoin treatment as well as monitoring measures during medication.

Dosage

Adults and young people:

start at a dose of 0.5 mg/kg/day. The usual dose is 0.5 - 1 mg/kg/day, taking 1-2 times/day at a meal.

Treatment time for response usually lasts 16 - 24 weeks. The total cumulative dose is 120 - 150 mg/kg, exceeding this dose does not bring more benefits.

In most cases, acne condition ends after only one treatment.

If recurrent, may consider the next round. The effect can last up to 8 weeks after the end of the treatment, so do not start the next treatment during this period.

Patients with renal failure:

Should start with low doses (10 mg/day), then increase to 1 mg/kg/day or until the maximum dose is tolerated.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

Children:

Due to lack of data on safety and effectiveness, do not use the drug to treat acne before puberty and in children under 12 years old.

Patients intended:

In patients with intolerance with recommended dose, daily dose can be reduced, leading to prolonged treatment time and increasing the risk of recurrence. To achieve the maximum effect in these patients, the maximum dose should be used.

What to do when overdose?

Overdose:

To reduce absorption: Gastrointestinal lavage can be applied in the first two hours after an overdose. Stop using drugs in patients with symptoms of overdose at the dose of treatment.

track:

Monitor the increase in intracranial pressure. Pregnancy tests for female patients must be at risk of pregnancy at an overdose and 1 month later. In the case of pregnancy, careful consideration of the continued pregnancy and the risk of fetal deformities. Blood test to determine the level of isotretinoin and its metabolites.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using acnotin, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Hemorrhage system: Anemia, thrombocytopenia, neutropen leukemia. Blood triglyceride increases, decreases high density lipoprotein, high blood cholesterol; Blood sugar increases. joint pain, muscle pain, back pain (especially in children and adolescents); Headache.

Rare, 1/10000 Skin allergic reaction, anaphylactic reaction, hypersensitivity; Hair loss.

depression, anxiety, mood change.

Gram -positive bacterial infection (skin - mucosa); Hypermand hypertension, convulsions, drowsiness, dizziness. diabetes; hyperuricemia.

Abnormal behavior, mental disorders.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acnotin drugs are contraindicated in the following cases:

hypersensitively to isotretinoin, soybean oil or any ingredients of
. Tell.

Excess vitamin A.

Precautions when using

isotretinoin is a highly capable of giving birth. Therefore, do not use acnotin for pregnant or pregnant women.

acne is a disease associated with androgen hormone, so do not use contraceptive pills containing compounds of Androgen progesterol as a substance originating from 19 - Nortesterol (norsteroid), especially in cases of endocrine problems.

Do not perform facial skin during treatment with acnotin as well as within 5 to 6 months after stopping treatment due to the risk of keloid scars in some non -specific skin areas.

Do not use hair waxes during treatment as well as within 5 to 6 months later because it can cause the risk of dermatitis.

For patients in high -risk groups such as diabetes, obesity, alcoholism, lipid metabolic disorders, regular checkups should be checked if necessary.

Simultaneous use of acnotin with tetracylin antibiotics because it can occur in increased intracranial pressure (headache, nausea, vomiting, angioedema). There have been depression, behavioral disorders and rare suicidal cases or really committed suicide because patients with depression treated with isotretinoin need to pay special attention.

Patients also need to be warned about disorders on the musculoskeletal system, on the skin, subcutaneous tissue, muscle inflammation, muscle pain and joint pain. At the beginning of treatment with acnotin, patients should use moisturizing products to avoid dehydration of the skin and lips. Avoid using wax wax, especially on the face, including 6 weeks after treatment because the skin is very thin, prone to peeling.

Avoid sun exposure and avoid ultraviolet rays during treatment with acnotin.

dry eyes, cornea, blurred vision will stop when stopping without taking acnotin. Consult the doctor when the situation occurs. People with contact lenses should wear glasses often during treatment.

In addition, lipid metabolic disorders, liver dysfunction, liver failure, digestive disorders rarely occur during treatment with acnotin.

The ability to drive and operate machinery

There has been a report on night vision reduction, drowsiness, dizziness, visual disorders. Therefore, it is necessary to be cautious when operating the train, machinery, working on high or other cases.

Pregnancy

isotretinoin is a highly likely to produce monster. Therefore, do not use acnotin for pregnant or pregnant women. Patients need to be examined to eliminate 2 weeks before treatment with isotretinoin, which should be used continuously within 1 month before treatment, during treatment and 1 month after stopping the drug.

If the patient detects pregnancy during treatment, the patient must immediately notify the doctor.

Breastfeeding period

isotretinoin has high lipid preference, so it is easy to export to breast milk. Do not use isotretinoin during breastfeeding due to the risk of side effects for children.

Drug interaction

Unused isotretinoin and vitamin A due to the risk of excess vitamin A. Has recorded some cases of increased intracranial pressure when used in combination with isotretinoin and tetracylin. Therefore, do not use tetracylin during the treatment of isotretinoin.

Avoid simultaneous use of isotretinoin with skin -to -skin -acne -prone skin -treated skin -treating skin because it increases the risk of skin irritation.

Storage

Store in dry, cool places below 30 ° C. Avoid light and heat.

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