Acnotin 20mg Mega We Care treatment for heavy acne (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Isotretinoin
Ingredient Acne

Ingredient

Composition information	Content
Isotretinoin	20mg

Uses

indications

Acnotin 20 drugs are indicated in the following cases:

Isotretinoin is a retinoid that treats acne in the whole body, indicated in case of severe acne, acne does not respond to conventional treatments, acne causes face deformation to leave many bad scars, long -term acne that seriously affects career and social psychology.

Pharmacokic

The real acting mechanism of Isotretinoin is not known. According to the current knowledge, Isotretine works to reduce sebaceous gland size and inhibit the activity of sebaceous glands, thus reducing sebum secretion. In addition, there is anti -inflammatory effect on the skin.

Pharmacokinetics

absorption

Isotretinoin is absorbed through the gastrointestinal tract, taking isotretinoin in meals can increase the bioavailability of the drug thanks to the absorption properties of the drug due to high lipid preference.

Distribution

Isotretinoin is strongly connected to plasma proteins, mainly albumin (99.9%).

Isotretinoin's distribution volume in humans has not been determined because isotretinoin is not as available as when using intravenous lines. Few information about Isotretinoin's distribution into tissues.

The concentration of isotretinoin in the epidermis is half of the serum.

Isotretinoin concentration in plasma is about 1.7 times compared to total blood due to the poor penetration of Isotretinoin into red blood cells.

Metabolism

Isotretinoin is metabolized in the liver and may be in the small intestine wall. The main metabolites are found in the blood and urine as 4 - Oxo - Isotretinoin. There are also other metabolites such as tretinoin and 4 - Oxo - tretinoin.

Elimination

Isotretinoin is eliminated by the owner thanks to the metabolism of the liver and excreted through bile. Isotretinoin is eliminated through feces and urine with equivalent amounts. The sale time of Isotretinoin is from 10 to 20 hours.

Before taking Acnotin 20mg Mega We Care treatment for heavy acne (3 blisters x 10 tablets)

How to use

acnotin 20 uses oral.

Dosage

The usual dosage in adults and young people is 0.5 - 1 mg/kg of weight per day (divided into two doses, used in meals) for 15-20 weeks.

The maximum dose is 2 mg/kg of weight per day is applied to patients with very severe acne or acne initially appearing on the chest or back instead of on the face.

The effectiveness of the treatment and side effects of the drug may vary in each patient after 4 weeks of treatment, so adjust the treatment dose maintenance in the range of 0.1 - 1 mg/kg of weight per day, specific cases of cases. During the early treatment with Isotretinoin, acne may appear slightly and transient, sometimes need treatment in combination with Adrenocorticoid therapy.

The treatment time usually lasts about 16 weeks. When evaluating the effectiveness of treatment, it should be noted that the condition still improves even when stopping the drug. Therefore, it is advisable to stop at least 8 weeks before starting treatment with isotretinoin and the reminded dose is the same as the initial treatment.

Concentrated with topical topical medications: Do not use simultaneously with topical acne medications that work on skin peeling, horn pepper or ultraviolet radiation. Patients should limit direct contact with sunlight. If necessary, it is possible to support treatment with acne medication on the spot has a mild effect.

The drug is not suitable to treat acne in children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Outdoor treatment

To reduce absorption: Gastrointestinal lavage can be applied in the first two hours after an overdose. Stop using drugs in patients with symptoms of overdose at the dose of treatment.

Track

Monitoring the increased intracranial pressure: Pregnancy tests for female patients are at risk of pregnancy at an overdose and 1 month later. In the case of pregnancy, careful consideration of the continued pregnancy and the risk of fetal formation. Blood test determines the level of isotretinoin and its metabolites.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using acnotin 20, you may experience unwanted effects (ADR).

Most of the side effects of isotretinoin are related to the dose, at the usual doses, the ratio between the risk and benefits of the drug is acceptable.

Not determined frequency

Symptoms of excess vitamin A: Often dry skin, mucosa, lip cracks, nosebleeds, eye conjunctivitis, corneal opaque recovery and unable to use contact lenses.

Skin and other side parts: extra rash, itching, dermatitis, pus sweat beans, inflammation around the nail, nail atrophy, granular tissue, hair loss, more fish eggs, hairs, hyperpigmentation, skin increased sensitive to light.

Muscle and bone: muscle pain, joint pain, bone proliferation, tendonitis and other changes in bone.

Mental and central nervous system: behavioral disorders, depression, headache, increased intracranial pressure, epilepsy. sensory: Market disorders, hearing loss at some of the most frequencies, fear of light, adaptive disorders in the darkness (reducing the market at night), swear cataracts, keratitis.

Digestive system: nausea, colitis, ileitis and colon, gastrointestinal bleeding.

Liver, bile: temporary and recovery increased, sometimes cases of hepatitis. In many cases, the change is still within normal limits and returns to the original value right during the treatment period. However, there are still some cases of reducing the dose or stopping drugs.

Respiratory: Bronchospasm. blood: leukopenia, red blood cells, increased or decreased platelets, increasing blood deposit rate.

Subclinical tests: Hyper cholesterol and serum triglycerides, hyperuricemia. HDL has been recorded, especially in high doses and in patients whose family has a history of lipid metabolism, diabetes, obesity or alcoholism. These changes are related to the dose and will return to normal when reducing the dose or stopping the drug. However, there is still a warning to patients about the side effects that may occur when taking the drug.

affect resistance: local or whole body infection caused by gram -positive bacteria (staphylococcus aureus).

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acnotin 20 drug contraindicated in the following cases:

Patients with liver function and renal function, vitamin A poisoning patients, patients with hyperlipidemia, patients with hypersensitivity to isotretinoin and any component of the drug.

Unsonized isotretinoin with tetracylin antibiotics.

Pregnant women, or are intended to be pregnant and nursing women.

Do not use the blood of the patient who is using or using isotretinoin 1 month earlier to blood transfusions to women during the intended period of pregnancy.

Be cautious when using

Warning

Absolutely follow the instructions for use.

Do not get pregnant during medication.

There is a risk of fetal defects if pregnant during medication.

Caution

Only use isotretinoin as directed by the physician with experienced body retinoid treatment (preferably a dermatologist) and understand the risk of monitoring if used for pregnant women.

Must check the liver function before treatment 1 month after the beginning of treatment and periodically every 3 months later.

Serum lipid concentration should also be tested before treatment 1 month after treatment and after 3-4 months of treatment.

There have been reports on depression, psychosis or suicide and suicide intentions related to isotretinoin treatment. Although the mechanism is unknown, it is necessary to care for special care for patients with a history of depression and must monitor these signs in all patients to take appropriate measures.

Doctors when visual problems or feel uncomfortable when wearing contact lenses. Reduction of vision includes symptoms such as fear of light, dry eyes or dizziness, these symptoms have a card that affects the ability to drive and operate machinery.

Be careful to evaluate the benefits and risks that may occur for patients and only use isotretinoin in severe cases.

Acne is a disease associated with androgen hormone, so it should not be used simultaneously with birth control pills containing androgen progesterol, such as the substance of 19 - Nortestosteron (norsteroid), especially in the case of endocrine problems.

Do not peel the face during the use of isotretinoin and 5 - 6 months after the drug is discontinued due to the risk of keloids.

Do not use hair waxes during the treatment of isotretinoin as well as within 5-6 months after stopping the drug because of the risk of dermatitis.

For special patients: Regularly checking subclinical data for patients in a high risk group (patients with diabetes, obesity patients, alcoholic patients or lipid metabolism disorders) are being treated with isotretinoin.

Measurement of blood glucose must be regularly measured in patients with illness or suspected diabetes. Although the relationship has not been identified, there have been reports on some cases of hyperglycemia very quickly, the risk of pancreatitis, intestinal inflammation, the effects on the ear, musculoskeletal system and some new diabetes are detected during the use of isotretinoin.

Dry mouth can cause teeth problems and worsen dental diseases such as tooth decay, gum disease and fungal infection. To limit the problems of teeth, you can use a solution to replace saliva, sugar -free candy, or ice.

The ability to drive and operate machinery

Patients using isotretinoin should be cautious when driving and operating machinery if there is visual symptoms such as dizziness, drowsiness when using the drug.

Pregnancy

Isotretinoin is at high risk of monitoring. Therefore, do not use isotretinoin for pregnant women or intended to get pregnant during the medication period. The risk is very high for the fetus if the mother is pregnant during the time of using the drug at any dose, even if only for treatment in a short time. The fetal abnormalities related to Isotretinoin have been recorded including hydrocephalus, small head defects, abnormalities in the outer ear (small or no external ear canal), eye atrophy, cardiovascular abnormalities and brain deformities.

Must use two methods of effective contraception effectively in 1 month before starting treatment, during treatment and 1 month after stopping treatment. Examination to remind patients about the importance of contraception. If pregnant during the medication period, you must consult your doctor about whether or not to be treated.

The period of breastfeeding

isotretinoin has high lipid preference, so it is easy to export to breast milk. Do not use isotretinoin during breastfeeding due to the risk of side effects for children.

Drug interaction

Unsonized use of isotretinoin and vitamin A because it can increase the symptoms of vitamin A.

There have been several cases of increased intracranial pressure when used in combination with isotretinoin and tetracylin. Therefore, do not use tetracylin during the treatment of isotretinoin.

The effect of low -dose progesterone may be reduced when used simultaneously with isotretinoin. Therefore, do not use preparations containing low -dose progesterone during the treatment of isotretinoin.

Phenytoin: Be careful when used in combination with phenytoin and isotretinoin simultaneously because it can reduce the effect of the drug.

Ketoconazole: Simultaneous use may increase the serum concentration of corticosteroids in plasma due to reducing the clearance of these two drugs. Corticosteroid dose adjustment may be necessary if used simultaneously.

Storage

Store in cool dry places, below 30 ° C. Avoid direct light.

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