Actadol 500 Medipharco treats pain and fever from mild to medium (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol
Indication Fever, headache, dysmenorrhea, muscle pain, inflammation, toothache, joint pain
Contraindication Drug allergy, deficiency G6PD

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

Indications

paracetamol is widely used in the treatment of pain and fever from mild to medium.

Pain

Paracetamol is used temporarily in the treatment of mild and medium pain: headache, toothache, dysmenorrhea, muscle pain ... The most effective drug is low -intensity pain relief of non -internal origin.

paracetamol has no effect on rheumatism.

paracetamol is a salicylate replacement (preferred in patients with contraindications or non -tolerance of salicylate) to reduce pain or fever.

Fever

paracetamol is often used to reduce body temperature in fever, when fever can be harmful or when reducing fever, the patient will be more comfortable. However, antipyretic therapy is generally not specific, does not affect the process of the basic disease, and can cover the patient's condition.

Pharmacological

No data.

pharmacokinetics

No data.

Before taking Actadol 500 Medipharco treats pain and fever from mild to medium (10 blisters x 10 tablets)

How to use

Actadol tablets for oral tablets.

Dosage

Adults and children over 11 years old: take 1 tablet/time, 4-6 hours/time, no more than 8 tablets/day; The one -times dose of 2 capsules can be helpful to relieve pain in some patients.

Children 9-11 years old: Take 1 capsule, 4-6 hours/time. No more than 5 tablets/day.

Children under 9 years of age: According to the instructions of the physician.

Do not use paracetamol to treat pain for more than 10 days in adults or more than 5 days in children, unless the physician is instructed, because of such a lot of pain and prolonged pain may be a sign of a pathological condition that needs a physician to diagnose and supervise.

Do not use paracetamol for adults and children to treat high fever on their own (above 39.5 ° C), fever lasts for more than 3 days, or recurrent fever, unless due to a physician, because such a fever may be a sign of a severe illness that needs to be diagnosed quickly by a physician.

To minimize the risk of overdose, do not give children more than 5 doses of paracetamoi to reduce pain or reduce fever within 24 hours, unless the physician is instructed.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Expression:

Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the poison of the drug.

Methemoglobin - Blood, leading to purple blue, mucous and nail is a sign of acute poisoning P - Aminophenol; A small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitated and delirious. Next can be inhibiting the central nervous system; Stunned, lower body temperature; tired; Breathing fast, shallow; fast, weak, uneven circuit; Low blood pressure; and circulatory failure. Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The suffocating convulsions may occur.

often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2-4 hours immediately after taking toxic dose, eventually dying from liver failure. Acute renal failure also occurs in some patients.

Treatment:

When severe poisoning, it is important to treat positive support. Need to wash stomach weight, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver. N-acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. Without N - Acetylcystein, methionine can be used.

Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Actadol often has unwanted effects (ADR).

Skin rash and other allergic reactions occur. Usually the beans or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. In a few individual cases, Paracetamol has caused neutropenia, thrombocytopenia and all bloody hematoma.

Uncommon and rare: ban, nausea, vomiting, disorder, anemia, reaction through the steven-johnson syndrome (SJS), toxic skin syndrome (Ten) or Lyell syndrome, acute all-body hat syndrome (AGEP) may occur when using paracetamol, although the incidence rate is not high.

Risk of cardiovascular thrombosis (see more warning and caution).

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Actadol drugs contraindicated in the following cases:

Hypersensitivity to Paracetamol.

Be cautious when using

Must use paracetamol carefully in patients with anemia before, because purple blue may not show clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol; Should avoid or limit drinking.

Use carefully for people with impaired liver or kidney function.

Serious side effects on the skin, although the incidence is not high but serious, even life-threatening includes: Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome: Toxic Epidermal Necrolysis (Ten) or Lyell Syndrome, Provincial Bodyburt Syndrome (AGEP).

Symptoms of the above -mentioned syndrome are described as follows:

Steven-Johnson syndrome (SJS): is a puffiness, puffiness allergy around the natural cavities: eyes, nose, mouth, ears, genitals and anus. In addition, it may be accompanied by high fever, pneumonia, liver dysfunction. Diagnosis of Steven-Johnson syndrome (SJS) has at least 2 naturally damaged cavities.

Poisoned skin necrosis syndrome (Ten): is the most severe drug allergy, including:

Diverse lesions in the skin: measles, pink, pink or puffiness, damage quickly spread throughout the body;

Eye mucosa lesions: keratitis, pus conjunctivitis, corneal ulcer;

Damage to the gastrointestinal mucosa: stomatitis, mouth mucosa, pharyngeal ulcer, esophagus, stomach, intestines.

Damage to the mucosa of genital tract, urinary tract.

There are also serious systemic symptoms such as fever, gastrointestinal bleeding, pneumonia, glomerulonephritis, hepatitis ... high mortality rate of 15-30%.

Excavaded pustules syndrome (AGEP): Small sterile hats arise on the spreading background. Damage often appears in folds such as armpits, groin and face, then can spread the whole body. Systemic symptoms are often fever, high neutral blood leukemia tests.

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had serious skin reactions caused by Paracetamol must not use the drug again and when they come to
medical examination and treatment, they need to notify the medical staff on this issue.

Risk of thrombosis: nonsteroidal anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic sugar, can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, the lowest daily daily daily dose is needed in the shortest possible time.

The effect of drugs on driving and operating machinery

does not affect.

Use drugs for pregnant or lactating women

Pregnancy: Paracetamol should only be used in pregnant people when really necessary.

Breastfeeding period: Research in mothers using paracetamol during breastfeeding, do not see unwanted effects in breastfeeding.

Interactive drug

long -term oral doses of high doses Paracetamol increases slightly anti -dynamic effects of cooumarin and indandion derivatives.

Simultaneous use of phenothiazin with paracetamol leads to the ability to cause serious fever.

Drinking a lot of alcohol and long -term can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (Phenytoin, Barbiturat, Carbamazepin) cause enzyme induction in the liver microsom, which can increase the toxic liver toxicity of paracetamol, due to increased drug metabolism into toxic derivatives to the liver.

Isoniazid simultaneously with paracetamol can also lead to an increased risk of liver toxicity.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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