Acyclovir 800mg Stella Pharm treated herpes Simplex virus infection (10 blisters x 5 tablets)

Dosage form Box of 10 blisters x 5 tablets
Specifications Acyclovir
Ingredient Stella

Ingredient

Composition information	Content
Acyclovir	800mg

Uses

indications

Acyclovir 800 drug is indicated in the following cases:

The treatment of herpes simplex virus on the skin and mucous membranes, including genital herpes contamination and recurrence. (shingles).

The inhibitory activity of acyclovir is highly selected by its affinity for thymidine kinase (TK) enzymes encoded by HSV and VZV. This enzyme converts acyclovir into acyclovir monophosphate, a nucleotide conductor. Monophosphate is transformed into diphosphate by the guiselate kinase of the cell and into triphosphate by some cell enzymes. In vitro, Acyclovir Triphosphate stops the DNA copy of the herpes virus. This process occurs in 3 lines:

Inhibit competition with the virus's DNA polymerase.

Pharmacokinetics

absorption

Acyclovir's oral bioavailability is about 20% (15 - 30%). Food does not affect the absorption of the drug. Time to reach the peak concentration in serum is about 1.5 - 2 hours.

Distribution

Acyclovir is widely distributed in body fluids and organs such as brain, kidneys, lungs, intestines, liver, spleen, muscle, uterus, mucosa and vaginal fluid, tears, aquatic fluid, semen, cerebrospinal fluid. Links to low protein (9 - 33%).

Metabolism

A small amount of drugs metabolized in the liver.

Elimination

Most of the drugs (30 - 90% of the dose) are eliminated through the kidneys in unchanged form. The sale time of the drug in adults is about 3 hours, in children from 2-3 hours, in newborns 4 hours.

Before taking Acyclovir 800mg Stella Pharm treated herpes Simplex virus infection (10 blisters x 5 tablets)

How to use

Acyclovir 800 drug used oral.

Dosage

Treatment of herpes Simplex infection includes genital herpes

200 mg/time x 5 times/day (4 hours apart) x 5 - 10 days.

If serious immunodeficiency or poor absorption

400 mg/time x 5 times/day x 5 days.

Preventing herpes simplex in patients with normal immunity

800 mg is divided into 2-4 times/day. The dose is higher than 1 grams/day can be used.

200 - 400 mg x 4 times/day.

Treatment for chronic disease prevention

Not suitable for mild or non -frequent relapse of herpes simplex. In these cases, treating each period of recurrence more effectively, using a dose of 200 mg x 5 times/day for 5 days, preferably in the stage of symptoms starting.

Chickenpox

800 mg x 4 or 5 times/day for about 5-7 days.

Herpes Zoster

800 mg x 5 times/day may be in about 7-10 days.

Dosage for people with renal failure

Should reduce the dose of acyclovir in patients with renal failure depending on the clearinine (cc).

Infection of Herpes Simplex: 200 mg every 12 hours.

infection with varicella zoster: 800 mg every 12 hours.

cc is about 10 and 25 ml/minute

infection of varicella zoster: 800 mg x 3 times/day every 8 hours.

Recommendation of the use of Acyclovir Stella 200 mg and/or Acyclovir Stella 400 when taking the dose of 200 mg, 400 mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Acyclovir 800, you may experience unwanted effects (ADR).

Renal failure may be related to the use of Acyclovir in some patients. This effect is often reversed and reported by response to hydration and/or decreased or stop -stop, but may progress to acute renal failure.

Side effects often occur after using systemic sugars including bilirubin in serum and liver enzymes, hematological changes, skin rash (including polycythemia, Stevens-Johnson syndrome and skin necrosis, fever, headache, dizziness and digestion effects such as nausea, vomiting and diarrhea. Hypersensitivity has been reported. Hepatitis and jaundice rarely encounter.

Instructions on how to handle ADR

When experiencing side effects of acyclovir stella 800mg, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acyclovir 800 drug is contraindicated in cases of hypersensitivity to acyclovir and valacyclovir.

Be cautious when used

acyclovir is eliminated through the kidneys, so the dose adjustment must be adjusted in patients with renal impairment and older patients (due to often impaired renal function). These two groups of patients increased the risk of unwanted effects in the nerves, so they need to carefully monitor the symptoms of unwanted effects. These reactions are generally recovered when stopped.

The ability to drive and operate machinery

There are no studies showing the influence of Acyclovir on driving and operating machinery.

Pregnancy

There are no adequate and controlled studies on pregnant women. Acyclovir should be used for pregnant women when the benefits are greater than the risk for the fetus.

Lactation period

Acyclovir Stella 800mg should be used carefully in breastfeeding women and only used when indicated.

Medicinal interaction

Simultaneous use Zidovudine and Acyclovir can cause drowsiness and sleep.

Probenecid inhibits competition to eliminate acyclovir through the renal tubules, so increase the sale time (up to 40%), reduce the excretion through urine and the renal clearance of acyclovir.

amphotericin B and ketoconazole increase the anti -virus effect of acyclovir.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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