Acyclovir Boston 200 drugs treat herpes Simplex, herpes zoster, chicken pox (5 blisters x 5 tablets)

Dosage form Box of 5 blisters x 5 tablets
Specifications Acyclovir
Ingredient Herpes Simplex infection, herpes zoster, genital herpes

Ingredient

Composition information	Content
Acyclovir	200mg

Uses

indications

Acyclovir drugs are used in the following cases:

The initial treatment and prophylaxis of Herpes Simplex Type 1 and 2 virus in the skin and mucosa, Herpes Simplex. Blood, chicken pox in humans immunodeficiency, chicken pox in infants.

When entering the body, acyclovir is phosphorylation to become an active form of Acyclovir Triphosphate that has the effect of inhibiting the DNA synthesis of the virus and the multiplication of the virus without affecting the metabolism of normal cells.

Acyclovir has the strongest effect on Herpes Simplex Type 1 virus and is worse in Herpes Simplex 2 virus, Varicella Zoster virus.

Pharmacokinetics

absorption

ACYCLOVIR's oral bioavailability is about 20% (15 - 30%), food does not affect the absorption of the drug.

Distribution

Acyclovir is widely distributed in the body fluid, the ratio is linked to low protein (9 - 35%).

Metabolism

A small amount of medication is metabolized in the liver, and mostly eliminated through the kidneys in non -change form.

Elimination

The sale time of the drug in adults is about 3 hours, in children about 2-3 hours, in newborns about 4 hours.

Before taking Acyclovir Boston 200 drugs treat herpes Simplex, herpes zoster, chicken pox (5 blisters x 5 tablets)

How to use

oral drugs, no need to pay attention to the meal. Should start taking the drug as soon as possible when there are signs and symptoms of the disease

Dosage

Treatment of Herpes Simplex infection

Adults: 200 mg/time x 5 times/day, used 4 hours apart and used for 5-10 days. In people with immunodeficiency for 400 mg/time x 5 times/day, used 4 hours apart and used for 5-10 days.

Children over 2 years: Use by adult dose.

Children under 2 years of age: Taking half of the adult dose.

Preventing herpes simplex for patients with immunodeficiency, transplants using immunosuppressants, HIV -infected people, users of therapy

Adults: 200 - 400 mg/time x 4 times/day, used about 6 hours apart.

Children over 2 years: Use by adult dose.

Children under 2 years of age: Taking half of the adult dose.

Treatment of chickenpox and shingles

Adults: 800 mg/time x 5 times/day, used 4 hours apart and used for 7 days.

Children with varicella disease: 20 mg/kg body weight/time (maximum 800 mg) x 4 times/day, used for 5 days, or can be used by dose:

Children under 2 years old: 200 mg/time x 4 times/day.

Children 2 - 5 years old: 400 mg/time x 4 times/day.

In the elderly, the body's total acyclovir clearance decreases in parallel with the creatinine clearance. Therefore, it is necessary to pay attention to water supplements for patients and adjust the dose suitable for patients with renal failure.

Renal failure

For patients with herpes Simplex or Varicella Zoster, the dose like normal people should note:

When the clearinine clearance is from 10 - 25 ml/minute: 8 hours to take the medicine 1 time.

When the clearance of creatinine is less than 10 ml/min: 1 hour to take the drug 1 time.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

There are results in the renal tubules (when the renal tubules are exceeding 2.5 mg/ml or when high serum creatinine), renal failure, stimulating state of restlessness, tremor, convulsions, chest drums, high blood pressure, difficulty urinating.

Treatment

Hemorrhage of patients until the kidney function recovers, stops drugs, gives water and electrolytes.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Acyclovir, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting (short -term).

Long -term use causes nausea, vomiting, abdominal pain, diarrhea, rash, headache.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acyclovir 200 drug is contraindicated in the case:

hypersensitivity to acyclovir or any ingredients of the drug.

Be cautious when used

need to adjust the dose according to creatinine clearance in patients with impaired renal function.

Note to take medicine with enough water and avoid coordination with kidney toxic drugs.

The ability to drive and operate machinery

Dizziness is an unwanted effect that has been recorded, so patients need to assess their reaction before driving or operating machinery.

Pregnancy

should only use Acyclovir for pregnant women when the benefits are much better than the risk of the fetus.

Lactation period

The drug is excreted by breast milk when used orally. Should be cautious when taking the drug for nursing women.

Drug interaction

Simultaneous use Zidovudin with acyclovir can cause a state of sleep and drowsiness.

Probenecid inhibits competition to eliminate acyclovir through the renal tubules, thus increasing the area under the curve and reducing the clearance of acyclovir.

amphotericin B and ketoconazole increase the anti -virus effect of acyclovir.

Interferon increases the anti -virus effect of acyclovir.

Storage

Store in a dry place, temperature below 30ºC, avoid light.

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