Acyclovir Medipharco skin cream treatment for herpes simplex virus (5g)

Dosage form Box
Specifications Acyclovir
Ingredient Herpes Simplex infection, herpes zoster, genital herpes

Ingredient

Composition information	Content
Acyclovir	250mg

Uses

indications

Acyclovir drugs are indicated in the following cases:

Treatment of herpes simplex virus infection (type 1 and 2) for the first time and relapse in the mucosa - da.

Pharmacokology

Acyclovir (Acycloguanosine) is a synthetic purine nucleoside, anti -virus effect Herpes Simex and Varicella Zoster. For effect, Acyclovir must be phosphoryl turned into activity form as acyclovir triphosphate.

Acyclovir Triphosphate inhibits the synthesis of DNA and the multiplication of the virus by inhibiting the enzyme enzyme DNA polymerase as well as the cohesion of the virus DNA without affecting the metabolism of normal cells. In non -contaminated cells of herpes virus, in vitro, acyclovir only cell enzymes (hosts) phosphorylation are only minimal. Acyclovir is also converted to Acyclovir Triphosphate with some other mechanisms because the drug works for some viruses without thymidine kinase (eg virusepstein-barr, cytomalovirus).

Acyclovir's

antiviral activity of the Epstein-BARR can be caused by the DNA polymerase of the virus that increases sensitivity inhibited with low concentrations of Acyclovir Triphosphate (created by phosphorylation enzymes). Cytomegalovirus resistance in humans may be due to inhibition of specific polypeptide synthesis of the virus. This inhibitor requires high concentration of Acyclovir or Acyclovir Triphosphate in vitro.

The mechanism of action against other sensitive viruses such as Epstein-Barr and Cytomegalovirus has not been clear, need further research.

The effect of the most powerful Acyclovir on Herpes Simplex Type 1 virus (HSV-1) and worse in Herpes Simplex Type 2 virus (HSV-2), Varicella Zoster virus (VZV), the weakest effect on Epstein Barring and Cytomegalovirus (CMV). Acyclovir does not work against potential viruses, but there are some evidence that the Herpes Simplex virus inhibitors are hidden in the early re -functioning stage.

Drug resistance: In vitro and in vivo, Herpes Simplex virus resistant to acyclovir increased due to the appearance of a short -term deficiency of the virus thymidine kinase, which is an essential enzyme for acyclovir to turn into activated form. There is also another anti -drug mechanism due to the change of characteristics of thymidine kinase or reducing sensitivity to the virus's DNA polymerase.

Acyclovir resistance due to thymidine kinase deficiency can be cross -resistant to other antiviral drugs that are also phosphorylation by this enzyme such as Brivudine, IDoxURIDine and Ganciclovir.

pharmacokinetics

absorption:

Acyclovir is poorly absorbed by oral. Oral bioavailability is about 10–20%. Food does not affect the absorption of the drug. After intravenously sodium salt intravenous injection of aciclovir, the concentration of drugs in cerebrospinal fluid achieved about 50% of the drug concentration in plasma.

Time to reach the peak concentration in serum after taken 1.5–2 hours. Acyclovir is often absorbed very rarely on healthy skin but can increase when changing the formula for preparation. Acyclovir 3% eye ointment reaches a relatively high concentration in the aesthetics but the amount of absorption into the blood is negligible.

Distribution:

Acyclovir is widely distributed in body fluids and organs such as brain, kidneys, lungs, intestines, liver, spleen, muscle, uterus, mucosa and tear fluid, aquatic fluid, semen, cerebrospinal fluid. The drug is linked to low protein (9–33%). Acyclovir passes the placenta fence and is distributed into breast milk with a concentration of 3 times in the mother serum.

Metabolism:

The drug is partially converted into the liver into 9-carboxymethylgylguanine (cmmg) and a small amount of 8-hydroxy-9- (2-hydroxyethylethylyl) guanine.

Era:

In patients with normal kidney function, the sale time is about 2–3 hours. In patients with chronic renal failure, the selling time increases and may reach 19.5 hours in patients with anuria. During the hemolysis period, the sale time is reduced to 5.7 hours and about 60% of the acyclovir dose is eliminated during the appraisal process.

Probenecid increases the selling time and AUC of Acyclovir. Aciclovir is excreted mainly in urine in the form of unchanged glomerular filtration and renal excretion. About 2% of the total dosage excreted through feces.

Most single doses of intravenous venous doses are eliminated in urine in the form of unchanged within 24 hours. In adults, there is normal renal function, about 30–90% of single veins dosage deducted through urine in the form of unchanged within 72 hours, approximately 8–14% and less than 0.2% excreted through urine in the form of cmmg and 8-hydroxy-9- (2-hydroxyethylethylyl) guanin (corresponding).

Before taking Acyclovir Medipharco skin cream treatment for herpes simplex virus (5g)

How to use

topical skin.

Dosage

Apply the drug to the lesions every 4 hours (5–6 times/day) for 5–7 days, starting as soon as symptoms appear.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? It is necessary to retain the instruction sheet, box or tube of this drug if possible. Overdose symptoms include nausea, vomiting, diarrhea.

Treatment by hemorrhage of patients until kidney function recovers, stops drugs, water transmission and electrolytes.

What to do when forgetting a dose? The drug should be applied again as soon as possible and in accordance with the recommended dosage.

Side Effects

When using Acyclovir, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Feeling hot or throbbing in the topical position.

Skin: Mild skin dry or peeling, itching.

Rare, 1/10000

Skin: skin rash, skin allergic reaction (contact dermatitis).

Very rare, ADR

Hypersensitivity reactions: Evala, urticaria.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Acyclovir drug is contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Not used in the ophthalmology.

Be cautious when using

Acyclovir cream is not recommended for mucosa as used inside the mouth, eyes or vagina. Should be particularly cautious, avoiding the case of accidentally putting the drug in the eye.

Be cautious with pregnant and lactating women, immunodeficiency patients.

The ability to drive and operate machinery

There has been no research on the effects of the drug on the ability to operate machinery, driving train, high -class people and other cases for topical drugs on acyclovir skin.

Pregnancy

only use medication for pregnant women when the benefits are more likely to be risky to the fetus.

breastfeeding period

Be cautious when taking the drug in breastfeeding women.

Drug interaction

has not detected drug interactions different from acyclovir when used to apply skin.

Storage

Leave a dry place, temperatures below 30ºC, avoid light.

Other drugs

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