Acyclovir Sinil skin cream treatment for herpes simplex virus (5g)

Dosage form Tube
Specifications Acyclovir
Ingredient Chickenpox, Herpes Simplex

Ingredient

Composition information	Content
Acyclovir	250mg

Uses

indications

Acyclovir sinil is indicated in the following cases:

Herpes Simplex treatment and genital herpes re -infections are severe forms as well as immune system impairment.

Pharmacokology

Because acyclovir is the same substance as nucleosid, it has a selective effect in the herpes virus cell. To get acyclover effects need to be phosphoryl turned into active ingredient Acyclovir Triphosphate. At the beginning, Acyclovir will be transformed into Acyclovir Monophosphate thanks to the enzyme of the thymidikinase virus, then transformed into Acyclovir Diphosphate and Acyclovir Triphosphate thanks to some other cell enzymes.

With Acyclovir, it is the strongest in the Herpes Simplex Typ1 virus and is worse in HSV 2. Clinically, the Acyclovir Sinil 5G cannot be effectively visible to the infected person CMV.

Dynamic pharmacokinetics

have been studying over 6 male patients voluntarily to evaluate Acyclovir absorption level. When applying the drug with an area of 710 cm2 5 times a day 2 hours apart in 4 days. The amount of cream will be excreted through daily quantitative urine and acyclovir concentration in plasma is quantified 1 hour after use.

The average acyclovir will be excreted in the urinary tract 0.04% and the serum concentration in serum is less than 0.01 μm with 5 patients and 1 patient is 0.014 μm in 1 patient. The drug has a very small body absorption.

Before taking Acyclovir Sinil skin cream treatment for herpes simplex virus (5g)

How to use

drugs used for topical application.

Dosage

apply 1 thin layer x 5 times/day, every 4 hours x 5 days.

If the lesions are healed after 5 days, continue to use the drug for another 5 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: Hemorrhage of patients until kidney function recovers, stops drugs, gives water and electrolytes.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Acyclovir Sinil, you may experience unwanted effects (ADR):

A burning sensation or as a needle may occur after using Acyclovir Cream. Some patients have rash or dry and mild skin.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Do not use drugs for patients with hypersensitivity to acyclovir.

Be cautious when using

only use the drug as an external preparation.

Do not use medication for cornea and mucosa to treat ophthalmic.

If applied to the mucosa such as the mouth or vagina may occur irritation.

The ability to drive and operate machinery

No report.

pregnancy and lactation

Acyclovir cream absorption in the common circulation is not significant, so the drug can be used for pregnant and lactating women.

Interactive drug

interactive cream with Probenecid medicine. Because when the interaction occurs, it will lead to fidelity and drowsiness. Moreover, Probenecid strongly inhibits the elimination of acyclovir through the renal tubules, so it will increase by 40% as well as reduce the excretion through urine and acyclovir clearance.

With amphotericin B and ketoconazole will cause anti -virus effects of acyclovir. With Interferon will increase the anti -virus effect of Acyclovir. Should be cautious when using acyclovir injection with the previous patient has a neurological reaction along with interferon. If using acyclovir injecting should be cautious with patients with a history of neurological reaction when using methotrexate.

Storage

Store in closed packaging, at room temperature not more than 30 ° C, avoid light.

Other drugs

Disclaimer

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