Acyclovir Stella 200mg medicine for treatment of herpes Simplex, Varicella Zoster (5 blisters x 5 tablets)

Dosage form Box of 5 blisters x 5 tablets
Specifications Acyclovir
Ingredient Infection of herpes simplex, genital herpes

Ingredient

Composition informationContent
Acyclovir200mg

Uses

indications

Acyclovir Stella 200 mg is indicated in the following cases:

The treatment of herpes simplex virus (type 1 and 2) for the first time and relapse in the mucosa - da (stomatitis, genital inflammation), in the eye (keratitis).

Preventive Preventive HSV: In the mucosa - there is a relapse of at least 6 times/year, in the eye (the keratitis recurs after 2 times/year) or the case of eye surgery.

Treatment of Varicella Zoster virus infection: shingles, prevent eye complications due to eye shingles; Chickenpox in patients> 2 years old.

Pharmacokology

Acyclovir is a synthetic purine nucleoside conductor with inhibited activity in vitro and in vivo virus Herpes simplex type 1 (HSV-1), Type 2 (HSV-2) and Varicella Zoster virus (VZV).

The inhibitory activity of acyclovir is highly selected by its affinity for thymidine kinase (TK) enzymes encoded by HSV and VZV. This enzyme converts acyclovir into acyclovir monophosphate, a nucleotide conductor.

monophosphate is transformed into diphosphate by the guiselate kinase of the cell and to triphosphate by some cell enzymes. In vitro, Acyclovir Triphosphate stops the DNA copy of the herpes virus. This process occurs in 3 lines:

Inhibit competition with virus polymerase DNA.

cohesion and end the DNA chain of the virus.

Viral polymerase DNA.

Acyclovir's HSV activity is better than VZV resistance due to its phosphorylation more effectively by the virus enzyme.

The most powerful Acyclovir on Herpes Simplex Type 1 virus (HSV-1) and worse in Herpes Simplex Type 2 virus (HSV-2), Varicella Zoster virus (VZV), the weakest effect on Epstein Barrr and Cytomegalovirus (CMV).

Acyclovir does not work against hidden viruses, but there are some evidence that the herpes Simplex virus inhibitors are hidden at the beginning of the regeneration.

Drug resistance: In vitro and in vivo, the herpes simplex virus of acyclovir resistance increased due to the appearance of a mutation of the virus's thymidine kinase deficiency, which is an essential enzyme for acyclovir to turn into activity.

There is also another anti -drug mechanism due to the change in the characteristics of thymidine kinase or reducing sensitivity to the virus's DNA polymerase DNA. Acyclovir resistance due to thymidine kinase deficiency can cause cross -resistance to other antiviral drugs that are also phosphorylation by this enzyme, such as Brivudin, IDoxuridine and Ganciclovir.

Anti -drug virus has become a problem for people with immunodeficiency. Especially, AIDS patients are often infected with herpes Simplex virus resistant to acyclovir in the skin, mucosa.

pharmacokinetics

absorption:

Acyclovir's oral bioavailability is about 20% (15–30%). Food does not affect the absorption of the drug. Time to reach peak concentration in plasma is about 1.5–2 hours.

Distribution:

Acyclovir is widely distributed in body fluids and organs such as brain, kidneys, lungs, intestines, liver, spleen, muscle, uterus, mucosa and vaginal fluid, tears, aquatic fluid, semen, cerebrospinal fluid. Links to low protein (9–33%).

Metabolism:

A small amount of drugs metabolized in the liver.

Era:

Most drugs (30–90% of the dose) are eliminated through the kidneys in a constant form. The sale time of the drug in adults is about 3 hours, in children from 2–3 hours, in newborns 4 hours.

Before taking Acyclovir Stella 200mg medicine for treatment of herpes Simplex, Varicella Zoster (5 blisters x 5 tablets)

How to use

oral medication.

Dosage

Treatment of Tien Phat Herpes Simplex infection includes genital herpes:

  • Normal doses take 200 mg/time x 5 times/day (4 hours apart) x 5–10 days.
  • If severe immunodeficiency or poor absorption: 400 mg/time x 5 times/day x 5 days.

    • Removing recurrence in humans with immunity (at least 6 recurrence/year):

  • Take 800 mg/day, divided into 2 times or 4 times. Treatment therapy must be stopped after 6–12 months to evaluate the results.
  • If recurrent

    Backup HSV in immunodeficiency people: 200–400 mg/time x 4 times/day.

    HSV infection in the eye:

  • Treatment of corneal inflammation: 400 mg/time x 5 times/day x 10 days.
  • Preventive recurrence of keratitis (after 3 recurrence/year): 800 mg/day, divided into 2 times. Review after 6–12 months of treatment.
  • In case of eye surgery: 800 mg/day, divided into 2 times.

    • shingles: Adults and children> 2 years: 800 mg/time x 5 times/day x 5–10 days.

    Chickenpox:

  • Adults: 800 mg/time x 4–5 times/day x 5–7 days.
  • 2 years old> 20mg/kg, maximum 800 mg/time, drink 4 times/day x 5 days.
  • Children ≥ 6 years: 800 mg/time x 4 times/day.
  • Children 2–5 years: 400mg/time x 4 times/day.

    • Adjust the dose in patients with renal failure: Dosage and number of drinks must vary depending on the degree of kidney damage.

    Hemolysis: Additional 1 dose immediately after each hemolysis. Oral dose for people with kidney failure with HIV is as follows:

    Creatinine clearance (ml/min)

    How to use

    80

    Do not adjust the dose

    50–80

    200–800 mg, 6–8 hours apart

    25–50

    200–800 mg, 8–12 hours apart

    10–25

    200–800 mg, 12–24 hours apart

    200–400 mg, 24 hours apart

    Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Hematoparoography significantly increases the removal of acyclovir in the blood and is therefore considered to be a control measure in case of symptoms overdose.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Acyclovir Stella 200 mg, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Neurological: dizziness, headache.
    • digestive: Nausea, vomiting, diarrhea, abdominal pain. skin: rash, itching, sensitive to light. Systemic body: fatigue, fever.

    Uncommon, 1/1000

  • Skin: urticaria, increasing the frequency of wandering hair loss.

    • Rare, 1/10000 ≤ ADR

  • Immune: Anaphylaxis.
  • Respiratory: Difficulty breathing.
    • liver - Most: Increase bilirubin recovery and enzymes related to the liver.

    Skin: Evaluation, diverse roses, Stevens - Johnson syndrome, poisoned epidermal necrosis. kidney - Ureter: increased blood urea and creatinine, renal failure.

    Very rare, ADR

  • Blood and lymphatic system: Anemia, leukopenia and platelets.
    • nerve: agitation, tremor, loss of air conditioning, language disorders, mental symptoms, brain disease, drowsiness, confusion state, hallucinations, drowsiness, convulsions, coma and discomfort.

    Hepatitis: Hepatitis and jaundice.

  • kidney - Ureter: acute renal failure, kidney pain.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Acyclovir Stella 200 mg drug is contraindicated in the following cases:

    Hypersensitivity to acyclovir and valacyclovir.

    Be cautious when used

    acyclovir is eliminated through the kidneys, so the dose adjustment must be adjusted in patients with renal impairment and older patients (due to often impaired renal function). These two groups of patients increased the risk of unwanted effects in the nerves, so they need to carefully monitor the symptoms of unwanted effects. These reactions are generally recovered when stopped.

    The ability to drive and operate machinery

    Pay attention to the patient's clinical status and the unwanted effect of Acyclovir when considering the ability to drive or operate machinery. Using Acyclovir sometimes causes drowsiness and drowsiness (usually occurs in patients with high doses or renal function), patients should certainly not be affected by drugs before driving or using machines.

    There are currently no studies showing the influence of Acyclovir on driving and operating machinery. Moreover, it is impossible to predict the adverse effects on these activities from the pharmaceutical properties of the active ingredient.

    Pregnancy

    There are no adequate and controlled studies on pregnant women. Acyclovir should be used for pregnant women when the benefits are greater than the risk for the fetus.

    Lactation period

    acyclovir should be used with caution in breastfeeding women and only used when specified.

    Drug interaction

    Simultaneous use of zidovudine and acyclovir can cause drowsiness and sleep.

    Probenecid inhibits competition to eliminate acyclovir through the renal tubules, so increase the sale time (up to 40%), reduce the excretion through urine and the renal clearance of acyclovir.

    amphotericin B and ketoconazole increase the anti -virus effect of acyclovir.

    There are several transplant patients with increased serum cyclosporin levels and there are signs of kidney toxicity when used simultaneously with acyclovir. Need to closely monitor kidney function in patients taking both drugs.

    cimetidine increases the AUC of acyclovir by competing active excretion through the renal tubules and reducing the clearance of acyclovir in the kidney. No need to adjust the dose of Acyclovir because of its wide treatment.

    Mycophenolate Mofetil: Increasing AUC in the plasma of acyclovir and non -activity metabolites of mycophenolate mofetil, immunosuppressant agent used for implant patients, has been shown when the two drugs are simultaneously used. However, there is no need to adjust the acyclovir dose because of the wide treatment range.

    Theophyllline: Concomitant treatment with acyclovir increases approximately 50% AUC of theophylline. Recommendation measurement of plasma concentration when treated simultaneously with acyclovir.

    Storage

    In closed packaging, dry place, avoiding light. The temperature does not exceed 30ºC.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    count views

    Popular Keywords