Acyclovir Stella 400mg medicine for herpes Simplex, Herpes Zoster, chicken pox (7 blisters x 5 tablets)

Dosage form Box of 7 blisters x 5 tablets
Specifications Acyclovir
Ingredient Infection of herpes simplex, genital herpes

Ingredient

Composition information	Content
Acyclovir	400mg

Uses

Indications

Acyclovir Stella 400mg drug is indicated in the following cases:

Treatment of herpes Simplex infection on the skin and mucous membranes includes genital herpes contamination and recurrence.

Prevent recurrence of herpes simplex in patients with normal immunity.

Prevention of herpes Simplex infection in immunodeficiency patients.

Treatment of Varicella infection (chickenpox) and herpes zoster infection (shingles).

Pharmacokology

acyclovir is a synthetic purin nucleosid conductor with inhibiting inhibitors in vito and in vivo virus Herpes Simplex TuyP 1 (HSV-1), TuyP 2 (HSV-2) and Varicella-Zoster virus (VZV). The inhibitory activity of acyclovir is highly selected by its affinity for the enzyme thymidin kinase (TK) encoded by HSV and VZV.This enzyme converts acyclovir into acyclovir monophosphate, a nucleotide conductor. Monophosphate is transformed into diphosphate by cell kinase and to triphosphate by some cell enzymes. In vitro, Acyclovir Triphosphate stops the Copy of the Herpes virus.

This process occurs in 3 lines:

Inhibit competition with the virus polymerase DNA.

pharmacokinetics

oral bioavailability of Acyclovir about 20% (about 15-30%). Food does not affect the absorption of the drug. Acyclovir is widely distributed in body fluids and organs such as brain, kidneys, lungs, liver, spleen, intestines, muscles, uterus, mucosa and vaginal fluid, tears, aquatic fluid, fluid, cerebrospinal fluid.

Links to low protein (9 - 33%). Time to reach peak concentration in plasma is about 1.5 - 2 hours.

Selling time in adults: 3 hours, in children: 2 - 3 hours, in newborns: 4 hours. A small amount of Acyclovir is metabolized in the liver and most (30 - 90% of the dose) is eliminated through the renal in a constant form.

Before taking Acyclovir Stella 400mg medicine for herpes Simplex, Herpes Zoster, chicken pox (7 blisters x 5 tablets)

How to use

Acyclovir Stella 400mg is used by oral.

Dosage

Adults

Treatment of herpes simplex, including genital herpes

Take 200mg x 5 times/day (usually every 4 hours when awake) for about 5-10 days.

Patients with serious immunodeficiency or malabsorption patients

Take 400mg x 5 times/day for about 5 days.

Preventing herpes simplex in patients with normal immunity

Take 800mg divided into 2-4 times/day. The dose can be reduced to 400 - 600mg/day. It can be used higher than 1g/day.

Treatment process should be stopped every 6 - 12 months to re -evaluate.

Prevention of Herpes Simplex in patients with immunodeficiency

Take 200 - 400mg x 4 times/day.

Treatment of chronic disease prevention

Not suitable for light or non -frequent recurrent herpes Simplex.

In these cases, treating each period of recurrence more effectively, using a dose of 200mg x 5 times/day for 5 days, preferably in the beginning of symptoms.

Chickenpox

Take 800mg x 4 or 5 times/day for about 5-7 days.

Herpes Zoster

Take 800mg x 5 times/day may be in about 7-10 days.

Dosage for people with renal failure

Should reduce the dose of acyclovir in patients with renal failure depending on the clearinine (cc).

Infection of Herpes Simplex: 200mg every 12 hours.

infection of varicella-zoster: 800mg every 12 hours.

cc is about 10 and 25ml/minute

Varicella-Zoster infection: 800mg x 3 times/day every 8 hours.

Children

Treatment of Herpes Simplex infection and preventing herpes Simplex infection in immunodeficiency patients

Children ≥ 2 years: like adult dose.

Children under 2 years of age: half the dose of adults.

Chickenpox treatment

continuously for 5 days.

Children ≥ 6 years: 800mg x 4 times/day.

Children from 2 - 5 years old: 400mg x 4 times/day.

Children under 2 years old: 200mg x 4 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

There is an acyclovir precipitate in the renal tubules when the concentration in the renal tubules exceeds 2.5mg/ml. Symptoms include: high serum creatinine, kidney failure, stimulating state, restlessness, tremor, convulsions, chest drums, hypertension, difficulty urinating.

Treatment

In case of acute and urinary renal failure, patients should be hemorrhage until the kidney function recovers. Stop the drug. For water and electrolytes.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Acyclovir Stella 400mg, you may experience unwanted effects (ADR).

Renal failure may be involved in the use of Acyclovir Stella 400mg in some patients, this effect is often reversible and is reported by response to hydration or decreased or stop -stop, but may progress to acute renal failure.

Side effects often occur after using systemic sugars including bilirubin in serum and liver enzymes, hematological changes, skin rash (including diverse roses, stevens-johnson syndrome and toxic epidermal necrosis), fever, headache, dizziness and affect digestion such as nausea, vomiting and diarrhea. Hypersensitivity has been reported. Hepatitis and jaundice are rarely reported.

Warnings

Contraindicated

Acyclovir Stella 400mg Contraindicated for patients with hypersensitivity to Acyclovir and Valacyclovir.

Caution when used

Acyclovir Stella 400mg is excreted through the kidney, so the dose adjustments in patients with renal insufficiency. Older patients often impaired renal function and therefore need to adjust the dose for this group of patients. Both older patients and patients with renal insufficiency increase the risk of nerve toxic side effects and should carefully monitor the signs of side effects. These reactions are generally recovered when stopped.

Driving and operating machinery

There has been no research on the impact of Acyclovir 400 mg on driving and operating machinery.

Pregnancy and lactation

Pregnancy

There are no adequate and controlled studies on pregnant women. Acyclovir 400mg should be used for pregnant women when the benefits are greater than the risk for the fetus.

Breastfeeding period

Acyclovir 400mg should be used carefully for breastfeeding women and only used when indicated.

Medicinal interaction

Simultaneous use Zidovudin and Acyclovir Stella 400mg can cause a state of sleep and drowsiness.

Probenecid inhibits competition to eliminate acyclovir through the renal tubules, increasing the sale time (up to 40%), reducing the excretion of urine and the renal clearance of acyclovir stella 400mg.

amphotericin B and ketoconazole increase the anti -virus effect of acyclovir.

Storage

Keep the medicine in a closed box, out of the reach of children.

Store at room temperature, in a dry place, away from direct light.

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