Adazol 400mg medicine 3-2 treatment for intestinal parasites (1 blister x 1 tablet)

Dosage form Film bag tablets
Specifications Box of 1 blister x 1 tablet
Ingredient Albendazol
Indication Casyworm infection, needle worm infection, eel worm infection, hairworm infection, hookworm infection
Contraindication Bone marrow poisoning

Ingredient

Composition information	Content
Albendazol	400mg

Uses

indications

Adazol® drugs are indicated in the following cases:

Infection of intestinal parasites such as roundworms, needle worms, hookworms, hairworms, eel worms.

The drug has a broad -active spectrum on intestinal worms such as hookworms (Ancylostoma duodenale, mine worms (necator Americanus), roundworm (Ascaris lumbricoides), needleworms (enterobius vericularis), eel worms (Strongyloides Steroralis), Hairworm (Trichuris Trichiurise) Capillaria (Capillaria Philippinensis), twisted worms (Trichinella Spiralis) and migrant larvae in muscle and skin.

Albendazole has an activity in both the adult and larvae stage of the intestinal worms and the symbolic discharge of roundworms and hair worms. The main metabolic form of albendazol is Albendazol Sulfoxid still works and holds an important position of the pharmacological effect of the drug.

The mechanism of action of albendazole is similar to other benzimidazols. The drug is associated with the sub -parasites, thereby inhibiting the coincidence of the sub -sub -trailers into the minor minor of the cytoplasm is essential for the normal activity of the parasitic cell.

Dynamic pharmacokinetics

In humans, after drinking, Albendazol is very absorbed very poorly (5%). Most anti -worm effects occur in the intestine. To have the effect of tissue, high and long -term doses.

Due to a very strong step of metabolism, albendazol is not seen or only seen in the form of plasma traces.

After taking a single dose of 400 mg of albendazole, the peak concentration of the sulfoxid metabolites is achieved in plasma about 0.04 - 0.55 micrograms/ml after 1 to 4 hours.

When taking medicine with fat foods, plasma concentrations increase by 2-4 times. There is a great difference between individuals in albendazol sulfoxid levels in plasma. It may be due to erratic absorption and due to the difference in the speed of drug metabolism.

Albendazol Sulfoxid binds to protein in plasma up to 70%. Albendazol Sulfoxid through the bloody barrier and concentration in the brain - marrow is about 1/3 of the plasma concentration.

Albendazole is rapid and completely oxidized, into a metabolic substance that still has the effect of Albendazol Sulfoxid, then converted into a compound no longer acting, Albendazol Sulfon.

Albendazole has half -life eliminated from plasma for about 9 hours. Sulfoxid metabolites are eliminated through the kidneys along with sulfon metabolites and other metabolites. A negligible amount of sulfoxid metabolism is excreted through bile.

Before taking Adazol 400mg medicine 3-2 treatment for intestinal parasites (1 blister x 1 tablet)

How to use. The tablet can be assigned to use chewing or swallowing.

Dosage

Treatment of roundworms, needle worms, hookworms, worms:

Adults and children over 2 years: 1 tablet, single dose. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Adazol®, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Fever.

Central nerve: headache, dizziness, brain manifestation, brain pressure increased. liver: abnormal liver function.

stomach - intestines: abdominal pain, nausea, vomiting.

Skin: Hair loss (recovery).

Uncommon, 1/1000

Systemic: allergic reactions.

blood: leukopenia.

Skin: skin, urticaria. kidney: Acute renal failure.

Rare, ADR

Blood: granulocytosis, general hemorrhage, grain leukemia, thrombocytopenia.

Instructions on how to handle ADR

When treating for a short time (no more than 3 days), some cases are uncomfortable in the gastrointestinal tract (epigastric pain, diarrhea) and headache. Usually unwanted effects are not severe and recover without treatment. Only stop treatment when leukocyte reduction (0.7%).

Notice to the doctor the unwanted effect when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Adazol® drug contraindicated in the following cases:

There is a history of allergies to benzimidazol compounds or one of the ingredients of the drug.

People with a history of bone marrow poisoning.

Pregnant women.

Be cautious when using

Patients with abnormal liver function before starting treatment with albendazole need to consider carefully because the drug is metabolized in the liver and has seen a few people with liver poisoning. It is also necessary to be cautious for people with kidney and nursing women.

The ability to drive and operate machinery

does not affect.

Pregnancy

Not used for pregnant women.

breastfeeding period

breastfeeding women should be cautious when using.

Drug interaction

dexamethason: The lowest stable concentration in the plasma of Albendazol Sulfoxid is about 50% higher when used in combination with 8 mg of dexamethasone with each dose of albendazol (15 mg/kg/day).

Praziquantel: Praziquantel (40 mg/kg) increases the average concentration in plasma and area under the curve of Albendazol Sulfoxid about 50% compared to the single albendazole (400 mg).

cimetidine: Albendazol sulfoxid concentration in bile and in fluka fluid increased by about twice in people with cysts when used in combination with cimetidine (10 mg/kg/day) compared to using single albendazole (20 mg/kg/day).

Storage

Leave a cool dry place, temperatures below 30 ° C, avoid light.

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