AGBACTAM 312.5 mekophar powder for infection treatment (12 packs)

Dosage form 12 package box
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, genital infections, skin and soft tissue infections, bone inflammation

Ingredient

Composition information	Content
Amoxicillin	250mg
Clavulanic Acid

Uses

indications

Agbactam 312.5mg drug is indicated in the following cases:

Upper respiratory infections:

tonsillitis, sinusitis, otitis media have been treated with common antibiotics but does not decrease.

Acute and chronic bronchitis, pneumonia - bronchial.

cystitis, urethritis, pyelonephritis (female genital tract infection).

Bone and joint infections: Bone inflammation.

Dental infection. Tooth abscess.

Other infections: Obstetrics and gynecology, abdominal cavity.

Pharmacokinus

Agbactam 312.5mg is an antibiotic with wide antibacterial spectrum. The combination of amoxicillin with clavulanic acid in AGBactam 312.5mg helps Amoxicillin not be destroyed by beta-lactamase, and expand the antibacterial spectrum of amoxicillin effectively for many resistant bacteria that are resistant to amoxicillin, other penicillins and cephalosporins such as:

Gram -positive bacteria: Streptococcus Faecalis, Streptococcus Pneumonia, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Coryebacterium, Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptoccus.

Gram negative: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, PasteRae Multocida, Bacteroides including B. Fragilis.

According to the information of the original drug:

Bacteria may have problems with drug resistance:

Aerobic Gram: Escherichia Coli, Klebsiella Oxytoca, Klebsiella Pneumoniae, Klebsiella spp., Proteus Mirabilis, Proteus Vulgaris, Proteus spp., Salmonella spp Aerobic grams: corynebacterium spp.

Bacteria that have been resistant to drugs:

Aerobic grams: Acinetobacter spp., Citrobacter Freundii, Entobacter spp Enterocolitica.

Other: Chlamydia Pneumoniae, Chlamydia Psittaci, Chlamydia spp., Coxiella Burnetii, Mycoplasma spp.

pharmacokinetics

Amoxicillin and clavulanic acid are easily absorbed by oral. The concentration of these 2 substances in serum reaches maximum after 1-2 hours of taking the medicine. Amoxicillin's oral bioactivity is 90% and of Clavulanic acid is 75%.

Amoxicillin's semi -waste time in serum is about 1-2 hours and of Clavulanic acid about 1 hour. 55 - 70% amoxicillin and 30 - 40% Clavulanic acid are discharged through urine in the form of unchanged.

Before taking AGBACTAM 312.5 mekophar powder for infection treatment (12 packs)

How to use

Mix the powder in a glass of water, stir and drink.

Dosage

adults and children> 12 years old:

Mild and medium infections: 2 packs, 12 hours/time.

Severe infections: 2 packs, 8 hours/time.

Children

The dose calculated in Amoxicillin: 20 - 45mg/kg body weight/day, depending on the level of infection, divided into several times 8 - 12 hours apart.

Usual dose:

Children from 6 -

Children from 2 -

Children from 9 months -

Adult dose in kidney failure:

Creatinine clearance> 30ml/min: No dose adjustment.

Creatinine clearance from 10 to 30ml/minute: 1-2 packs, 12 hours/time.

Creatinine clearance

Hemolysis: 1 - 2 packs, 24 hours/time, drink during and after the fertilizer.

Should take the medicine at the beginning of the meal to minimize the phenomenon of non -intolerance in the stomach - intestines.

Treatment must not exceed 14 days without examination.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? However, the acute reactions occur depending on the hypersensitivity of each individual.

The risk is definitely increased blood potassium when taking very high doses because Clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from the circulatory system.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using AGBACTAM 312.5, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea.

Skin: Outdoor, itching.

Uncommon, 1/1000

Blood: Nothing hypernagus,

digestive: Nausea, vomiting liver: Hepatitis and jaundice, hyperplation of transaminase.

rare, 1/10000

Systemic: Anaphylaxis reactions, edema Quincke.

Blood: A mitigation of platelets, leukopenia, hemolytic anemia. digestive: fake colitis, Stevens - Johnson syndrome. skin: diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning. kidney: interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Agbactam 312.5 contraindications in the following cases:

Sensitive to the beta-lactamase group (penicillin, cephalosporin) or with one of the ingredients of the drug.

People with a history of jaundice or liver disorders, bile due to the use of amoxicillin, clavulanate or penicillin.

Be cautious when using

for patients with signs of liver dysfunction, kidney failure.

Due to the drug contains aspartame, avoid use in the case of phenylketon.

The ability to drive and operate machinery

has not seen the drug that affects the ability to drive or operate the machine.

Pregnancy

Avoid using AGBACTam 312.5 for pregnant women, especially in the first 3 months, except for the necessary cases prescribed by the doctor.

The period of breastfeeding

During breastfeeding can use AGBACTAM 312.5. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Interactive drug

The drug can cause prolonged bleeding time and prothrombin time. Therefore, it is necessary to be careful for those who are treated with anticoagulants.

The drug can reduce the effectiveness of oral contraceptives, so it is necessary to notify the patient in advance.

Probiecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

To avoid interactions between drugs, notify the doctor or pharmacist about the drugs being used.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

To be out of reach of children.

Mekophar Pharmaceutical - Pharmaceutical Company was established in 1975, called the Central Pharmaceutical Enterprise 24, a member unit of Vietnam Pharmaceutical Corporation.In 2001, the company officially renamed Mekophar Pharmaceutical - Pharmaceutical Joint Stock Company. Mekophar's development orientation is to invest in research and development, especially research to put into production of new high quality products, appropriate prices, build new pharmaceutical production lines meeting GMP-WHO standards, increase capital for production and business activities, ensure and improve product quality of international standards that have been affirmed.

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