Agdicerin 50mg Agimexpharm Treatment of symptoms of hip and knee degenerative diseases (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Diacerein
Ingredient Osteoarthritis, knee osteoarthritis

Ingredient

Composition information	Content
Diacerein	50mg

Uses

Indications

Agdicerin drugs are indicated in the following cases:

Symptomatic treatment for patients with hip or knee osteoarthritis, with slow effect. and anti -rheumatism, no steroids.

ATC code: M01AX21.

diacerein is anti -osteoarthritis and is used to treat osteoarthritis (osteoarthritis and related diseases), well tolerated in the stomach because the drug does not inhibit the synthesis of prostaglandin. Diacerein is one of the current anti -osteoarthritis drugs that can affect both assimilation and catabolism of cartilage cells and reduce inflammatory factors. The results of some studies in vito and in vivo showed that Diacerein and Rhein, a metabolic substance of it, inhibit the production and activity of the currency and costly cytokine IL-1B, both in the shallow and deep layer of cartilage, in the epidemic membrane and the epidemic membrane while stimulating the production of the transition growth factor (TGF-B) and other basic ingredients of the cell as cells as cells as cell cells as cell cell as Proteoglycan, Aggrecan, Hyaluronic Acid and Type II glue. In addition, these substances also show inhibition of macrophages and movement of macrophages. Studies in some animal osteoarthritis models show that diacerein reduces cartilage degeneration compared to untreated groups.

Clinical studies show significant pain relief and significant joint improvement compared to placebo (placo) after 1 month of treatment with diacerein. Other studies show that the beneficial effect of Diacerein treatment lasts at least 2 months after stopping treatment. A randomly blind study between the placebo group and the control group, conducted in many centers for 3 years (Ichodiah research) more than 507 patients with hip osteoarthritis showed that Diacerein significantly slows down cartilage degeneration.

pharmacokinetics

Good absorption through the gastrointestinal tract after drinking.

Distribution in the shallow layer and deep layer of cartilage, in epidemic membranes and epidemic membranes.

metabolic diacerein in the liver for active metabolites is Rhein.

Elimination mainly through sub -road.

Before taking Agdicerin 50mg Agimexpharm Treatment of symptoms of hip and knee degenerative diseases (3 blisters x 10 tablets)

How to use

Should take medicine with meals.

The drug must be swallowed intact (not broken drugs) with 1 glass of water.

Dosage

The use of Agdicerin should be started by a doctor who has experience in treating osteoarthritis.

Dosage mode

The dosage is often used for adults

Because some patients may have loose or diarrhea, Diacerein's recommended starting dose is 50mg once a day for dinner for the first 2-4 weeks. Then can increase to 50mg twice a day. At that time, you should take medicine with meals (1 pill at breakfast and the other for dinner).

However, because the Agdicerin 50mg has a slow -on -effective onset and the beneficial effect is observed after 2-4 weeks of treatment, it is necessary to encourage patients not to stop treatment before the effectiveness of the drug is clearly visible. Because Agdicerin does not inhibit prostaglandin synthesis, the drug is not harmful to the stomach, so it can be prescribed safe with an nonsteroidal anti -inflammatory drug (NSAID) for the first 2-4 weeks of treatment.

Agdicerin is not prescribed for patients over 65 years old, especially patients with a history of diarrhea.

What to do when overdose? Need symptomatic treatment. If diarrhea lasts, please see your doctor. Emergency treatment includes water -electrolyte recovery if necessary.

Actively monitor for timely handling measures.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Agdicerin, you may experience unwanted effects (ADR).

Gastrointestinal disorders

Increase the food time through the intestines and abdominal pain is the most common side effect during treatment with diacerein. These symptoms may appear in the first few days of treatment and in most cases.

Very common (1/10): diarrhea , abdominal pain.

Common (1/100 and

These effects will be relieved when continuing to use the drug. In some cases, serious diarrhea has complications such as dehydration and electrolyte balance disorders.

Liver system disorders

Less (1/1000 and

Skin and tissue disorders

Common (1/100 and

Note in patients using Agdicerin sometimes more dark yellow urine, this is a typical sign of the compound in the drug and has no clinical significance.

Notify the doctor with unwanted effects when using the drug.

How to handle ADR

With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticoid ...).

Warnings

Before using Agdicerin, you need to read the instructions for use carefully and refer to the information below.

Contraindicated

Agdicerin drugs contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug or those with a history of sensitivity to the derivatives of anthraquinon.

Precautions when using

should consider the benefits and risks of using Agdicerin medication for patients with previous intestinal disorders, especially the colon is easily stimulated.

diarrhea

Agdicerin regularly can cause diarrhea (see the unwanted effect), thereby leading to dehydration and hypokalemia. Patients should stop using diacerein when diarrhea and exchange with the doctor for treatment of alternative treatments.

Be careful when using Agdicerin for patients who use diuretics due to increased risk of dehydration and hypokalemia.

Particularly cautious to prevent blood potassium when patients use simultaneously cardiaces (digitoxin, digoxin).

Avoid simultaneous use of Agdicerin with laxatives.

Liver poisoning

Increased serum liver enzyme level and acute liver damage symptoms were recorded during the circulation of Agdicerin in the market.

Before starting treatment with Agdicerin, it is advisable to ask the patient about attached diseases and history, especially liver diseases and screening the main causes of progressive liver disease. If diagnosed with liver disease is identified, contraindicated using Agdicerin.

Need to closely monitor the signs of liver damage and caution when using Agdicerin simultaneously with liver damage drugs. Recommended patients to reduce alcohol while being treated with Agdicerin.

Stop using Agdicerin if detected liver enzyme or suspected signs or symptoms of liver damage. Advise patients on the signs and symptoms of liver toxicity and ask the patient to immediately contact the treating doctor in case of detecting signs of liver damage.

Renal failure changes the pharmacokinetics of diacerein, therefore, the dose should be reduced in these cases (creatinine clearance

Do not prescribe Agdicerin for children under 15 years old because there is no clinical studies in this age group.

The ability to drive and operate machinery

does not observe that it affects the ability to drive and operate machinery.

Pregnancy and nursing mothers

Do not take drugs in pregnant women because there is no adequate data to assess the effect that can cause deformities or toxic to the fetus of Agdicerin during pregnancy.

There is no information on the toxicity of the drug for the fetus.

There are reports that the small amount of Diacerein derivative goes into breast milk. Therefore, do not take Agdicerin while breastfeeding.

Medicinal interaction

using Agdicerin can cause diarrhea and hypokalemia. Be careful when used simultaneously with diuretics (diuretics and thiazids) or with cardiac glycosides (digitoxin, digoxin ) due to increased risk of arrhythmia (see warning and caution).

Should avoid simultaneously with salt, oxid or aluminum hydroxid, calcium and magnesium hydroxids because they reduce the absorption of diacerein. These substances can be used at another time (2 hours away) after taking Agdicerin.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.