Agetoxib 60 Agimexpharm treatments for osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Etoricoxib
Ingredient Agimex

Ingredient

Composition information	Content
Etoricoxib	60mg

Uses

indications

Agetoxib drugs are indicated in the following cases:

Treatment of symptoms of osteoarthritis, rheumatoid arthritis, vertebral arthritis as well as pain relief and millions of acute gout attacks in adults and children over the age of 16.

Short -term treatment for pain relief is both related to dental surgery in adults and children over 16 years old.

Pharmacokology

Etoricoxib is an non-steroid anti-inflammatory drug (NSAID0 has anti-inflammatory, analgesic activity, fever and is a strong, very selective Cycloxygenase-2 inhibitor (COX-2) inhibitors. Prostaglandin, responding to trauma or certain diseases. The prostaglandin causes pain, swelling and inflammation, so NSAID prevents the production of these substances, the drug is effective and reduced.

Selective inhibition of COX-2 reduces clinical signs and symptoms along with reducing toxicity in the digestive tract without having the effect of platelet function.

pharmacokinetics

absorption: Etoricoxib is well absorbed by oral. The average bioavailability reaches nearly 100% and the time of reaching the peak concentration in plasma is 1 hour.

Distribution: About 90% of the drug associated with protein without causing significant changes in the level and absorption speed when used with food.

Metabolism: Etoricoxib metabolizes mainly in the liver thanks to the cytochrom P450 3A4 enzyme system.

Elimination: The drug is excreted mainly through urine. The sale time is 22 hours.

Before taking Agetoxib 60 Agimexpharm treatments for osteoarthritis (3 blisters x 10 tablets)

How to use

oral medication, can be taken or not with food.

Dosage

For each different condition of osteoarthritis, there will be a different way to use Agietoxib 60 dose as follows:

Osteoarthritis: 60 mg/time/day, at a dose of 30 mg/time/day is not enough to respond. In the case of drug use but painless symptoms need to choose other drugs instead.

Acute gout attacks: Take the drug no more than 8 days at a dose of 120 mg/time/day at acute pain.

rheumatoid arthritis, cervical vertebra stiffness: recommend 60 mg/time/day, if not effective, increase the dose of 90 mg/time/day. When clinical stability, maintained at 60 mg/time/day.

Acute pain after tooth surgery: 90 mg/time/day, up to 3 days.

Chronic muscular pain: 60 mg/day/day and in the case of acute pain may increase the dose to 120 mg/time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

Patients with renal failure:

Creatinine clearance ≥ 30ml/minute: No dose adjustment.

Light liver failure (Child-Pugh: 5-6): Use no more than 60 mg/day/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

How to handle: In case of overdose, reasonable treatment is to apply commonly used support measures such as removing substances that have not been absorbed from the gastrointestinal tract, clinical monitoring and supportive treatment, if necessary.

cannot remove Etoricoxib by blood decomposition.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Agetoxib eye drops, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neuroscope: drowsiness, fatigue, headache, insomnia, dizziness;

digestion: abdominal pain;

Infection and KST infection: roasted bone bone;

Metabolism and nutrition: edema/water retention;

nerve: dizziness, headache; blood vessels: high blood pressure; Respiratory: Bronchospasm;

digestive: constipation, flatulence ...

Uncommon, 1/1000

Infections and KST infections: gastritis, upper respiratory infection, urinary tract infection.

blood and lymph: Anemia, leukemia, thrombocytopenia. immune: Hypersensitivity reaction.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Agetoxib 60mg drug is contraindicated in the following cases:

Hypersensitivity to Etoricoxib or any ingredient of the drug;

Stomach ulcers or gastrointestinal bleeding; Severe liver failure (Child-Pugh ³ 10);

Inflammation;

Cerebral vascular disease;

Renal failure CLCR cystitis;

NYHA II-IV);

Patients with high blood pressure with regular blood pressure above 140/90mmHg and not fully controlled;

Ischemic heart disease, peripheral artery disease and brain disease;

History of asthma, acute rhinitis, nasal polyps, neurotransmitters, urticaria or allergic reactions after taking aspirin or nonsteroidal anti-inflammatory drugs including COX-2 inhibitors;

Pregnant or lactating women;

Children under 16 years old.

Be cautious when using

use cautiously in the elderly and those at high risk of gastrointestinal complications with NSAID. Patients are using another NSAID or acetylsalicylic acid when taking Agetoxib 60 also need to pay special attention.

Be cautious for patients with cardiovascular disease or blood pressure, impaired liver and kidney function.

Due to the increased risk of the risk of the heart of Etoricoxib, the daily dose should be used in the shortest time.

Patients are often edema due to many causes, water retention (such as heart failure, kidneys), high blood pressure should also be very careful when using the drug because it makes the disease worse.

Cases of cell dehydration because diuretics need to be treated for dehydration before using Agietoxib 60.

Etoricoxib can cover the signs of inflammation such as fever, pain ...

The excipient contains lactose, tartrazine color. Patients with rare genetic problems in tolerance Galactose, Lapp Lactase deficiency or malposive glucose-Galactose should not take this drug.

The ability to drive and operate machinery

The drug can cause dizziness, drowsiness or headache, so it affects the ability to drive and operate machinery.

Pregnancy

Avoid drug use during pregnancy due to Etoricoxib may cause an early fetal arterial closing in the last 3 months of pregnancy.

Pregnant women during treatment need to stop using drugs.

Breastfeeding period

It is not known whether Etoricoxib will be excreted through breast milk or not so it should not be used for breastfeeding women.

Interactive drug

Antaginalism: The drug increases 13% of prothrombin time, which should be monitored with blood clotting tests in patients who are taking anticoagulants such as Warfarin.

Rifampin: Reducing the concentration of Etoricoxib in plasma.

Methotrexate: Caution should be considered for a dose of 90 mg at the same time with Etoricoxib.

Diuretics, enzyme inhibitors and Angiotensin II antagonists: simultaneously use with Etoricoxib to reduce the effect. Precautions in elderly patients, kidney function weakened by increasing kidney function including renal failure.

lithium: Etoricoxib increases the concentration of the drug in plasma, so closely monitor to detect poisonous symptoms of lithium.

Aspirin: Using low -dose aspirin with Etoricoxib leads to an increase in the rate of gastrointestinal ulcers or other complications.

Oral contraceptives: Used with contraceptives containing ethinyl estradiol, increasing the concentration of the drug, which may increase the incidence of side effects related to birth control pills (venous thrombolytic embolism in risky women).

Hormone replacement therapy: Increases the risk of secondary effects when used at the same time as Etoricoxib.

Be cautious when used with drugs mainly metabolized by sulfotransferase (oral salbutamol, minoxidil).

Storage

Store in a dry place, avoid moisture and light, temperature below 30 ºC.

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