Agicardi 5mg Agimexpharm treat hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bisoprolol
Ingredient Neurasthenia, high blood pressure, angina

Ingredient

Composition information	Content
Bisoprolol	5mg

Uses

indications

Agicardi drugs are indicated in the following cases:

Treatment of mild to medium hypertension cases. The membrane and no effect is like the intrinsic sympathetic nerve when used within the scope of treatment. With low doses, Bisoprolol inhibits selectively responding to adrenalin stimulation by blocking the Beta 1 adrenergic receptor of the heart, but has little effect on the receptor β2 adrenergic of bronchial muscles and vascular walls. With high doses (for example, 20 mg or more), the selective properties of bisoprolol on receptors β1 usually decrease and the drug will compete inhibiting both receptors β1 and β2.

Bisoprolol is used to treat hypertension. Bisoprolol's effectiveness is equivalent to other beta blockers. The mechanism of lowering blood pressure effects of Bisoprolol may include the following factors: Reducing heart flow, renal inhibition releases renin and reducing the impact of sympathetic nerve from vasomotor centers in the brain.

But the most outstanding effect of Bisoprolol is to reduce the heart frequency, both at leave and at exertion. Bisoprolol reduces the flow of the heart at a break and when exertion, accompanied by a few changes in the volume of blood exposed in each heart squeeze, and only increases less right atrial pressure or pulmonary capillary pressure at rest and exertion.Unless there is a contraindication or an intolerant patient, beta blockers have been used in combination with angiotensin, diuretic and heart glycosides inhibitors to treat heart failure caused by left ventricular dysplasia, to reduce heart failure.

The good effect of beta blockers in the treatment of congestive heart failure is mainly due to inhibition of the effects of sympathetic nervous system. Using long -term beta blockers, as well as angiotensin transferring enzyme inhibitors, can reduce the symptoms of heart failure and improve the clinical condition of people with chronic heart failure. These good effects have been proven in people who are taking an angiotensin transferring enzyme inhibitors, showing inhibitors in combination of the Renin - Angiotensin and sympathetic nervous system.

pharmacokinetics

bisoprolol is almost completely absorbed through the digestive tract. Because only in initial metabolism is very little, oral bioavails are about 90%. After drinking, the peak concentration in plasma is reached from 2-4 hours. About 30% of drugs attached to plasma proteins.

Food does not affect the absorption of the drug. Half life eliminated in plasma from 10 to 12 hours. Bisoprolol dissolves moderate in lipid. Metabolic drugs in the liver and excretion in urine, about 50% in constant form and 50% in the form of metabolites.

In the elderly, half -life eliminated in plasma is slightly longer than young people, although the average plasma concentration in a stable state increases, there is no significant difference in the accumulation of bisoprolol between young and elderly people.

In people with creatinine clearance ratio below 40 ml/minute, half -life plasma increases about 3 times compared to normal people.

In people with cirrhosis, the rate of excretion of Bisoprolol changes more and lower is significant than normal people (8.3 - 21.7 hours).

Before taking Agicardi 5mg Agimexpharm treat hypertension, angina (3 blisters x 10 tablets)

How to use

take Agicardi before or during breakfast.

Dosage

Dosage used as directed by the doctor and is adjusted to each patient.

Hypertension, angina

In adults

The first usual dose is 2.5 - 5 mg x 1 time/day. Can increase the dose to 10 mg 1 time/day, maximum 20 mg x 1 time/day.

In people with bronchial spasms

The starting dose is 2.5 mg x 1 time/day.

Stable chronic heart failure

Treatment must be monitored by cardiologist, must start with a period of dose adjustment, the dose is gradually increased by the following dose:

1.25 mg x 1 time/day (morning) x 1 week; If tolerated, increased by 2.5 mg x 1 time/day x 1 week; If tolerated well, increase to 5 mg x 1 time/day x 4 weeks; If tolerated well, increase to 7.5 mg x 1 time/day x 4 weeks; If tolerated well, increase to 10 mg x 1 time/day for maintenance treatment.

kidney failure or liver failure in people with chronic heart failure

There is no dynamic data of Bisoprolol's pharmacokinetics in patients with chronic heart failure impaired liver or kidney function. Increasing dose in these patients must be very careful.

Elderly

No need to adjust the dose.

Children

There is no data. Do not recommend using drugs for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Observed the slow heart rate and/or hypotension. In some cases, the drugs have been used as sympathetic nerve and all the patients have recovered.

Signs of overdose due to beta blockers include slow heartbeat, hypotension and sleeping, and if severe, delirium, coma, convulsions and respiratory arrest. Sound blood failure, bronchospasm and hypoglycemia may occur, especially in people who have diseases in these organs.

If an overdose occurs, bisoprolol must be stopped and symptomatic support treatment. There are a few data that suggest bisoprolol fumarat cannot be separated.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Agicardi medicine you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, vomiting.

Respiratory: rhinitis.

General: weakness, fatigue.

Uncommon, 1/1000

Muscle muscle: joint pain.

TKTW system: reduces sensory, difficult to sleep.

Cardiovascular: Slow heart rate. digestive: nausea.

Respiratory: Difficulty breathing.

general: chest pain, peripheral edema.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Agicardi drugs contraindicated in the following cases:

Patients with hypersensitivity to Bisoprolol Fumarat.

Patients with heart shock, acute heart failure, untreated heart failure by foundation, heart failure III or IV, atrial - ventricular 2 or 3 and sinus heart rate (less than 60 times/minute before treatment), Sinus node disease, severe asthma or lung disease - chronic bronchial obstructive.

Severe Reynaud syndrome.

Patients with adrenal marrow tumors (chrome cell tumors) before being treated.

Pregnant, lactating women.

Children.

Be cautious when used

Avoid drugs in cases of uncontrolled congestion.

Do not stop the drug suddenly because it can increase angina, ventricular arrhythmia, myocardial infarction in patients with coronary artery disease, gradually decreased dose.

Precautions used for patients with peripheral vascular disease, bronchospasm (bronchial asthma, respiratory obstruction), kidney failure or liver failure.

The drug can cover the symptoms of hypoglycemia such as rapid vessels and clinical manifestations of thyroid disease.

The ability to drive and operate machinery

There has been no research on the effect of the drug on the ability to drive and operate machinery. However, depending on the reaction of each individual and due to the various effects of the drug's ability to drive and operate machinery may be impaired. It should be paid special attention when starting treatment and when increasing the dose, when taking the drug with alcohol.

Pregnancy

only use bisoprolol for women during pregnancy if the benefits are likely to be able to occur for fetuses.

Breastfeeding period

whether Bisoprolol is excreted in human milk or not. Because many drugs are excreted in human milk, it is necessary to be cautious when using bisoprolol for women who are breastfeeding.

Drug interaction

Do not combine bisoprolol with other beta blockers. Need to closely monitor patients taking drugs that consume catecholamine, such as reserpin or guanethidin, because the increase in the effect of beta - adrenergic blocker can cause excessive decrease in sympathetic activity. In patients treated simultaneously with clonidin, if needed to stop treatment, bisoprolol should be stopped for many days before stopping clonidin.

Be careful to use bisoprolol when used simultaneously with cardiomyopathy inhibitors or atrial - ventricular inhibitors, like some calcium antagonistic drugs, especially in the groups of phenylalkylamin (verapamil) and benzothiazepine (diltiazem), or anti -arrhyths, such as disopyramid.

.The simultaneous use of rifampicin increases the clearance of bisoprolol metabolism, resulting in shortening the half -life of bisoprolol excretion. However, usually not the first dose adjustment.

Risk of anaphylactic reaction: While using beta blockers, patients have a history of anaphylactic reaction with different allergens that may react more strongly to the use of repeated drugs, due to accidental, diagnosis or due to treatment. Such patients may not respond to epinephrin doses often used to treat allergic reactions.

Storage

temperature below 30 ° C, avoid moisture and light.

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