Agicetam 1200 Agimexpharm treat dizziness, memory impairment, stroke due to acute ischemia (3 blisters x 10 tablets)

ATC code: N06BX03

Piracetam (derivative of Gamma-butyric gamma acid, GABA) is considered as a substance that has a mental effect (improving the metabolism of nerve cells), although it is not well known about its specific effects as well as its mechanism of action.

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin, dopamin ... This can explain the positive effect of the drug on learning and improve the ability to perform memory tests. The drug can change neurotransmitter and contribute to improving the metabolic environment so that the nerve cells work well. On experiments, Piracetam has a protective effect against metabolic disorders due to ischemic by increasing brain resistance to oxygen deficiency. Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain. Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate and reducing glucose and lactic acid accumulation. Under normal conditions as well as without oxygen, piracetam increases the amount of ATP in the brain due to increased ADP conversion to ATP; This may be a mechanism to explain some useful effects of the drug. The impact on acetylcholine transmission (increasing the release of acetylcholin) may also contribute to the mechanism of action of the drug. The drug also works to increase the release of dopamine and this may have a good effect on the formation of memory. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neuron and no effect of GABA.

Piracetam reduces the ability to converge platelet and reduces blood viscosity in high doses, in case of abnormal erythrocytes, the drug can cause red blood cells to recover the ability to deform and pass through the capillaries. The drug has anti -vibration effect. Although some countries use piracetam in the treatment of intellectual dementia and cognitive decline, a system assessment concluded that the evidence from the orthodox medical medicine did not support the use of piracetam for these treatments.

Dynamic pharmacokinetics

absorption: Piracetam used by oral is absorbed quickly and almost entirely in the digestive tract. Bioions reach nearly 100%. Peak concentration in plasma (40 - 60 micrograms/ml) appears 30 minutes after taking a dose of 2 g. The peak concentration in the cerebrospinal fluid is achieved after taking the drug 2 - 8 hours. Absorption of drugs does not change during long -term treatment.

Distribution: The distribution volume is about 0.6 liters/kg. Piracetam absorbed into all tissues and may pass through the blood - the brain of the placenta and even the membranes used in the renal rosal. The drug has high concentrations in the cerebral cortex, frontal lobe, top lobe and occipital lobes, cerebellum and base cores.

Metabolism, excretion: Semi -selling time in plasma is 4-5 hours. Sell ​​waste time in cerebrospinal fluid is about 6 - 8 hours.

Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact. Piracetam clearance coefficient of the kidney in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. If the kidney failure, the sale time increases: In patients with complete renal failure and not recovering, the sale time is 48 - 50 hours.

Can reduce the side effects of the drug by reducing the dose.

Be cautious when used

Because Piracetam is discharged through the kidneys, the half -life of the drug increases directly to the degree of renal failure and creatinine clearance. It is necessary to be very cautious when taking the drug for patients with renal failure. Kidney function should be monitored in these patients and elderly patients (adjust the dose based on the clearing coefficient of creatinine).

Avoid stopping the sudden drug in patients with muscle vibration due to the risk of seizures.

Precautions in patients with stomach ulcers, a history of stroke due to bleeding, use with drugs that cause bleeding due to increased risk of bleeding.

Precautions in major surgery due to potential coagulation disorders.

The effect of drugs on driving and operating machinery

The drug has almost no effect on driving and operating machinery. However, there are also a few reports on the risk of dizziness, so the doctor may depend on each specific case that recommends whether or not recommend that patients take the drug when driving and operating machinery.

Use drugs for women during pregnancy and lactation

Do not use piracetam for pregnant or lactating women.

Women who are likely to be pregnant or are using contraception or pregnancy should consult a doctor carefully before treatment with this drug.

Medicinal interaction

can still continue the classic treatment for alcoholism (vitamins and sedatives) in the case of a person with vitamin deficiency or strong agitation.

When used simultaneously with thyroid essence: there is a case of confusion, stimulation and sleep disorders.

In a patient, prothrombin time has been stabilized by warfarin when using piracetam.

The cavalry of the drug:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.