Agicetam 800 Agimexpharm Treatment Symptomatic Symptoms (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Piracetam
Ingredient muscle vibration, cognitive impairment, memory impairment, difficulty learning in children, chronic alcoholism, stroke, headache, nerve inflammation, dizziness

Ingredient

Composition information	Content
Piracetam	800mg

Uses

indications

Agicetam 800mg drug is indicated in adult patients:

Improve symptoms of dizziness .

Support in the treatment of symptoms of cognitive diseases and chronic neuropathy in the elderly (excluding Alzheimer's disease and other dementia).

Treatment of muscle vibration of the cerebral cortex does not distinguish the cause and should be used in combination with other anti -seizures.

Pharmacy

piracetam (the ring of the aminobutyric gamma acid, GABA), is considered a substance with excitement effect (improving the metabolism of neuron cells) even though people do not know much about its specific effects as well as its mechanism of effect.

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin , dopamine ... The drug can change a neurotransmitter and contribute to improving metabolic environment so that neurons work well. On experiments, Piracetam has a protective effect against metabolic disorders due to ischemic by increasing brain resistance to oxygen deficiency.

Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain. The drug also works to increase the release of dopamine, which works well on the formation of memory.

Piracetam has no effect on sleep, sedation, resuscitation, pain relief.

Piracetam reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and ability to pass through capillaries. The drug has anti -vibration effect.

pharmacokinetic

absorption

Piracetam used by oral is absorbed quickly and almost entirely in the gastrointestinal tract. Birth nearly 100%. Absorption of drugs does not change during long -term treatment.

Distribution

The distribution volume is about 0.6L/kg. Piracetam absorbed into all tissues and can pass through the bloody brain barrier, placenta and even the membranes used in the renal roses. Piracetam is not attached to plasma proteins.

Elimination

is excreted through the kidneys in the form of intact, the renal piracetam clearance coefficient in normal people is 86ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. In people with kidney failure, the selling time increases.

Before taking Agicetam 800 Agimexpharm Treatment Symptomatic Symptoms (10 blisters x 10 tablets)

How to use

Agicetam 800 medicine is taken orally. Should take the pill with a full glass of water, can be taken with food or not.

Dosage

recommended doses as appointed

Treatment of muscle vibration

Dosage should start at a dose of 7.2g/day, divided into 2-3 times. Depending on the response, every 3-4 days, an increase of 4.8g daily to the maximum dose of 24g/day. Treatment with other anti -vibration medications should be maintained at the same dose. Depending on the clinical benefits achieved, the dose should be reduced, if possible.

Once you have started, treat with Agicetam 800, so it continues to exist. In patients with an acute attack, the disease may progress well after a period of time and so every 6 months should try reducing the dose or stopping treatment. Should be reduced by 1.2g of Piracetam every 2 days (every 3 or 4 days in the event of a Lance - Adams syndrome to prevent the possibility of sudden recurrence or seizures due to sudden suspension).

Support treatment in the treatment of symptoms of cognitive diseases and chronic neuropathy in the elderly and dizziness: take 1 tablet/time x 3 times/day (morning, lunch and dark).

Special subjects

Elderly

Should adjust the dose in the elderly with kidney function damage.

When long -term treatment in the elderly, regular evaluation of creatinine clearance is needed to adjust the appropriate dose when necessary.

Patients with renal failure

Contraindicated drug for patients with severe renal impairment (renal creatinine clearance below 20ml/minute).

Daily dose is calculated for each patient according to the kidney function. Refer to the table below and adjust the dose as directed. To use this dose table, it is necessary to estimate the patient's creatinine clearance coefficient (CLCR) in ml/min. The evaluation of creatinine (ml/min) can be estimated from serum creatinine levels (mg/dl) through the following formula:

CLCR = {[140 - Age (year)] x Weight (kg)/[72 x Creatinin serum (mg/dl)]} (x 0.85 in women).

Group Creatinine clearance coefficient (ml/min) Light 50 - 79 ⅔ Daily dose, divided 2-3 times The time

end-stage kidney disease -

No dose adjustment in patients only has liver failure. The drug should be adjusted in patients with both liver failure and kidney failure.

What to do when overdose? The highest overdose is reported by taking Piracetam dose of 75g. A case of bleeding diarrhea and abdominal pain associated with piracetam 75g per day, it is likely to be related to the very high sorbitol dose in the composition of the drug.

How to handle

In case of significant, acute overdose, the stomach can be drums with the use of vomiting. There is no specific antidote for Piracetam overdose. Treatment of overdose mainly treat symptoms and may include hemorrhage. The efficiency of the splitting machine is 50 - 60% for piracetam.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Agicetam 800mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Fatigue.

digestive: Nausea, vomiting, diarrhea , abdominal pain, abdominal distention. nerve: restlessness, prone to agitation, headache, insomnia, sleep.

Uncommon, 1/1000

Body: Dizziness.

nerve: Run, sexual stimulation, stress, increase movement, depression.

Hematology: Bloody disorders or severe bleeding.

Skin: Dermatitis, itching, urticaria.

How to handle ADR

Can reduce the side effects of the drug by reducing the dose.

Warnings

Before using the drug, you need to read the instructions carefully and refer to the information below.

Contraindicated

Agicetam 800mg drug contraindicated in the following cases:

Patients with severe renal impairment (creatinine clearance coefficient below 20ml/minute).

People with Huntington.

Brain hemorrhage.

Sensitive people with any ingredients of the drug.

Pregnant and lactating women.

Precautions when using

The impact on platelet gathering: Due to the effects of Agicetam 800 on platelet aggregation, should be cautious when used for patients with severe bleeding, patients are at risk of bleeding such as gastrointestinal ulcers, potential coagulopathy patients, patients with a history of hemorrhagic blood vessels, patients with hemorrhagic surgery including surgical surgery, including surgical surgery, including surgical surgery Anti -platelet aggregation drugs include low -dose aspirin.

kidney failure

Agicetam 800 is eliminated through the kidneys, so be careful in the case of renal failure (see the dose and how to use).

Elderly

When long -term treatment in the elderly, regular evaluation of creatinine clearance is needed to adjust the appropriate dose when necessary (see the dose and how to use).

Stop drugs

Should avoid sudden treatment because it can cause muscle seizures or body seizures in some patients with muscle vibration.

Pregnancy and lactation

Pregnancy

There is no enough data on the use of Agicetam 800 in pregnant women. Animal studies do not show direct or indirect effects on pregnancy, embryo or fetal development, post -development after birth.

Agicetam 800 passes the placenta fence. The drug concentration in babies is about 70% to 90% of the mother's concentration.

Do not use Agicetam 800 during pregnancy unless it is really necessary, when the benefits are superior to the risk and clinical status of pregnant women need to be treated with Agicetam 800.

Women who are likely to be pregnant or are using contraception or pregnancy should consult a doctor carefully before treatment with this drug.

Breastfeeding period

Agicetam 800 is secreted into breast milk. Therefore, Agicetam 800 should not be used while breastfeeding or not breastfeeding during treatment with Agicetam 800. It should be taken into account the benefits of breastfeeding for babies and the benefits of treatment for mothers when deciding not to breastfeed or do not use Agicetam 800.

The ability to drive and operate machinery

The drug has almost no effect on driving and operating machinery. However, there are also a few reports on the risk of dizziness, so the doctor may depend on the specific case that is recommended or not recommended for patients to use drugs when driving and operating machinery.

Medicinal interaction

pharmacokinetic interaction

The drug interaction can lead to piracetam's pharmacokinetic changes that are lowly predicted because about 90% of the doses of piracetam are discharged in urine in constant form.

In vitro, Piracetam does not inhibit the isomers of Cytochrom P450 in the liver CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 4A9/11 at concentrations 142, 426 and 1422 4G/mL.

At 1422 4g/ml concentration, observing the slightly inhibited effect on CYP 2A6 (21%) and 3A4/5 (11%). However, when the concentration exceeds 1422 4g/ml, the KI value of inhibiting these two types of CYP isomers is very good. Therefore, the metabolic interaction of piracetam with other drugs is almost none.

Thyroid hormones: Confusion, ease of stimulation and sleep disorders were recorded when taking this drug at the same time with thyroid essences (T3+T4).

acenocoumarol : In a single blind study in patients with severe recurrent recurrent vein thrombosis, the dose of piracetam 9.6 g/day does not change the dose of acenocoumarol necessary to reach Inr 2.5 to 3.5, but compared to the effect of acenocoumarol used alone, the supplement of Piracetam 9.6 8-THROMBOGLOBULIN, Fibrinogen levels and Von Willebrand elements (Villc; VIII: WW: AG; VIII: VK: ROO) and the viscosity of whole blood and plasma.

Anti -epileptic drugs: Piracetam daily use of 20g per week does not change the peak concentration and blood concentration of serum of anti -epileptic drugs (carbamazepin, phenytoin, phenobarbiton, valprooat) in epilepsy patients taking stable doses.

Alcohol: Drinking alcohol at the same time does not affect the concentration of piracetam in serum and alcohol levels not changed by a dose of 1.6g piracetam.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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