Agicipro 500mg Agimexpharm medicine is used in infections, urinary tract infections (10 blisters x 10 tablets)

antibacterial spectrum:

Ciprofloxacin has a very wide antibacterial spectrum, including most important pathogens. Most gram -negative bacteria, including pseudomonas and enterobacter are sensitive to drugs.

Bacteria that cause intestinal diseases such as Salmonella, Shigella, Yersina and Vibrio Cholerae are often highly sensitive. However, with the increasing use and abuse of drugs, there was a report on increasing the anti -drug rate of Salmonella.

The bacteria that cause respiratory diseases such as Haemophilus and Legionella are often sensitive, Mycoplasma and Chlamydia are only sensitive to medium -sized.

Neisseria is often very sensitive to drugs.

In general, Gram -positive bacteria (Enterococcus strains, Staphylococcus, Streptococcus, Listeria monocytogenes ...) are less sensitive. Ciprofloxacin does not work on most anaerobic bacteria.

Due to the special mechanism of action of the drug, Ciprofloxacin has no cross -effects with other antibiotics such as aminoglycosides, cephalosporin, tetracyclin, penicillin ...

Pharmacokinetics

absorption

Ciprofloxacin is quickly absorbed, easy through the gastrointestinal tract and reaches the maximum concentration in the blood 1-2 hours after drinking, with absolute biological use of 70 - 80%. Maximum maximum concentration in serum corresponding to doses of 500mg, 750mg, 1000mg is 2.4mg/liter, 4.3mg/liter and 5.4mg/liter.

The half -life is about 3.5 - 4.5 hours in people with normal renal function. In patients with renal failure and the elderly, the half -life is longer.

Distribution

The distribution of ciprofloxacin is very large (2-3 liters/kg body weight). After oral, the drug is widely distributed and has high concentrations in places with infections (tissues and fluid fluids).

The concentration of drugs in tissue is usually higher than the serum concentration, especially in parenchyma, muscle, bile and prostate. The concentration in lymphatic fluid and extracellular fluid is also close to the serum concentration.

The drug is also distributed into saliva, sputum, secretion in the nose, abdominal fluid, skin, cartilage and bone. Low cerebrospinal fluid concentration.

ciprofloxacin passes through the placenta and excreted through breast milk. In honey also has high levels of drugs.

Elimination

Ciprofloxacin is eliminated in the form of unchanged urine about 40 - 50%.

Other elimination lines are metabolic in the liver, exit through bile and excreted through the mucosa into the intestine.

The drug is excreted within 24 hours.

Be cautious when using

for patients with a history of epilepsy or central nervous system disorders, liver, kidney failure, muscle weakness, 6 phosphate dehydrogenase.The long -term use of ciprofloxacin can cause non -sensitive bacteria to overdue drugs. It is necessary to monitor patients and make antibiotics regularly to take appropriate treatments according to antibiotics.

ciprofloxacin can make mycobacterium tuberculosis tests negative.

Be cautious when driving or operating machinery.

Limit the use of ciprofloxacin for young and old children (on the experimental drug that causes cartilage degeneration in gravity joints).

Serious reactions are likely to not recover and cause disabilities, including tendonitis, tendon, peripheral neuropathy and adverse effects on the central nervous system.

Fluoroquinolon antibiotics are associated with serious harmful reactions that can cause disabilities and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion). These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may have these harmful reactions.

Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have had serious reactions related to fluoroquinolon.

used for pregnant and lactating women

during pregnancy is only used when really necessary and carefully monitored.

Do not use ciprofloxacin for nursing women (if the mother is forced to use ciprofloxacin, they must stop breastfeeding).

The effect of drugs when driving and operating machinery

The drug can cause dizziness, insomnia, hallucinations and confusion, so be cautious for trainers and operate machinery.

Interactive drug

Concentrated nonsteroidal anti -inflammatory drugs (ibuprofen, indomethacin ...) will increase the side effects of ciprofloxacin.

Simultaneous use of anti -acid drugs with aluminum and magnesium will reduce serum levels and reduce bioavailability of ciprofloxacin (should take anti -acid drugs 2 - 4 hours before taking ciprofloxacin)

The absorption of ciprofloxacin is half reduced if used simultaneously a number of cytotoxic drugs (cyclophosphamid, vincistin, doxorubicin, cytosin arabinosid, mitozantron).

If used simultaneously, didanosin will reduce ciprofloxacin levels. Ciprofloxacin should be taken before using Didanosin for 2 hours or after using Didanosin 6 hours.

iron preparations (fumarat, gluconate, sulfate) reduce the absorption of ciprofloxacin in the intestine. Avoid simultaneous use of ciprofloxacin with iron or zinc -oriented preparations or take these drugs as far as possible.

Take the sucralfate at the same time reduces the absorption of ciprofloxacin. You should drink 2 - 6 hours before taking sucralfat.

Take Ciprofloxacin simultaneously with theophylin may increase the concentration of theophylin in serum, causing the side effects of theophylin. The chest of theophylin concentration in the blood, and may be reduced by theophylin if it is forced to take 2 drugs.

ciprofloxacin and ciclosporin use simultaneously can cause temporary increased serum creatinine. Should check blood creatinine twice a week.

Probenecid reduces glomerular filtration level and reduces the excretion in the renal tubules, thus reducing the elimination of drugs through urine.

Ciprofloxacin increases the effects of anticoagulants such as warfarin. Need to regularly check blood prothrombin and adjust the dose of anticoagulants.