Agidopa Agimexpharm treat hypertension (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Methyldopa
Ingredient Agimex

Ingredient

Composition information	Content
Methyldopa	250mg

Uses

indications

Agidopa drugs are used in the following cases:

Patient high blood pressure .

People with hypertension are too high but use other drugs inefficient or too small.

Methyldopa is relatively safe and well tolerated, so it can be used for people with kidney failure, patients with heart failure left. However, you should still tell the doctor if you are in these cases.

Pharmacokic

Methyldopa is the Alfa-adrenergic stimulant to reduce peripheral sympathetic energy. It has the effect of reducing sympathetic and cancellation of adrenergic receptor.

pharmacokinetic

absorption

Methyldopa absorbed through digestion about 50%. The drug appears after 4 hours and can last up to 24 hours.

Distribution

weak drugs with plasma proteins. Drugs through placenta and breast milk.

Metabolism

Metabolic drugs through the liver for the first time should be used by low gastrointestinal tract (about 25%).

Elimination

methyldopa is eliminated through the kidneys slowly. Selling time is about 2 hours.

Before taking Agidopa Agimexpharm treat hypertension (2 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

The beginning of the treatment

Methyldopa's usual starting dose is 250mg, 2 to 3 times a day, for the first 48 hours. This dose is then adjusted depending on the response of each patient. To minimize sedative effects, should start increasing the dose in the evening.

Maintenance treatment

The usual dose of methyldopa is 0.5 - 2g/day, divided 2-4 times. The maximum daily dose is recommended as 3g.

Should use a combination of thiazid diuretics if not started with thiazid or if the effect of reducing blood pressure is not achieved with methyldopa doses of 2g/day.

Methyldopa is excreted in large quantities through the kidneys and people with renal impairment may respond to a smaller dose. Fainting in the elderly may be related to an increase in drug sensitivity or atherosclerosis. This can be avoided by lower doses.

Elderly

Initial dose 125mg 2 times daily, the dose may increase gradually. Maximum dose of 2g/day.

Children

The starting dose is 10mg/kg body weight/day, divided into 2-4 times. The maximum dose is 65mg/kg or 3g/day.

What to do when overdose?

Cases of overdose, usually only treat symptoms and support. When taken medication, you can wash your stomach or cause vomiting. If the drug has been absorbed, it can be transmitted to increase the elimination of the drug through the urine. Special attention should be paid to heart frequency, blood flow, electrolyte balance, intestinal paralysis and brain activity.

Can use drugs that are similar to sympathetic effects such as: levarterenol, epinephrin, metaraminol .

methyldopa can be excluded from circulation by hemorrhage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Agidopa, you may experience unwanted effects (ADR).

Prolonged methyldopa treatment, 10-20% of patients with positive coombs reaction. In this case, in a rare situation, it can be combined with hemolytic anemia and then can lead to deadly complications.

Common side effects:

Body: headache , dizziness, fever.

circulating: Hypotension posture, hypotension when standing, edema.

Central nerve: sedation. Endocrine: Sexual reduction. digestion: dry mouth, nausea, vomiting, diarrhea.

Respiratory: Stuffy nose.

Side effects:

Body: weakness .

nerve: Reduce intellectual sensitivity, paresthesia. Mental: Nightmare, depression .

Rare side effects:

Blood: Bone marrow failure, leukopenia, granulocytosis, thrombocytopenia, hemolytic anemia, huge red blood cell anemia.

Circulation: Slow heart rate, worsen angina, heart failure, sinus impairment syndrome.

Central nervous system: face paralysis, incontinence dance movement, cerebral circulatory syndrome, Parkinson -like symptoms.

endocrine: amenorrhea, big breasts in men, lactation.

digestive: colitis, salivary gland inflammation, black tongue, flatulence, pancreatitis. Skin: Outdoor, poisoned epidermal necrosis. liver: jaundice, hepatitis, microscopy in each region.

muscle and skeletal: The joints have or not swollen joints, muscle pain.

Other: myocarditis , pericarditis , diseases like erythema lupus.

How to handle

If hemolytic anemia occurs with a positive cooom reaction (this reaction usually occurs after 6 - 12 months of treatment), the cause may be due to methyldopa, in this case, the drug should be stopped. The lowest incidence if the daily dose is equal to or less than 1g. Usually the symptoms of anemia decrease rapidly. If not supported, corticosteroids can be used, in case of need for blood transfusion, and should consider other causes of anemia. If hemolytic anemia is associated with methyldopa, it is not advisable to continue taking the drug.

Hemolysis is occasionally occurring not related to positive or negative cooom reactions. This case occurs in people with glucose deficiency - 6 - phosphate dehydrogenase, with a higher rate in residential areas exposed to malaria compared to residential areas not exposed to malaria.

Sedative effects can occur at the beginning of the drug or when increasing the dose, but this unwanted effect will end up when performing maintenance treatment.

When using methyldopa, the main effect is mainly fever due to drugs. The fever occasionally accompanied by eosin hypercasses or liver dysfunction on testing, fever that may occur in stages, but usually only occurs in the first 3 weeks of the treatment. Jaundice may occur but also usually in the first 2 or 3 months of taking the drug.

Warnings

Before using the drug, you need to read the instructions carefully and refer to the information below.

Contraindicated

Agidopa drug is contraindicated in the following cases:

Sensitive to any ingredients of the drug.

acute hepatitis and progressive cirrhosis.

Liver dysfunction related to Methyldopa treatment before.

Chromic cells.

The person who is taking Mao inhibitors.

Lactating women.

Be cautious when using

methyldopa should be used carefully in the following cases:

History of liver disease or liver dysfunction in advance.

Severe kidney failure.

History of hemolytic anemia.

Parkinson's disease.

Depression psychiatric.

Porphyrin metabolic disorders.

Atherosclerosis.

should periodically quantify white blood cells and test the liver for the first 6-12 weeks of treatment or when the patient has a fever but for unknown reasons.

Pregnancy and nursing mothers

Methyldopa may be used for hypertension caused by pregnancy. The drug does not cause teratogenicity, but among babies born from mothers who have been treated with drugs during pregnancy, sometimes there is a period of hypotension.

methyldopa is excreted into breast milk, which can cause risks for children with the dose of treatment commonly used for nursing mothers. So the drug should not be used for nursing mothers.

The ability to drive and operate machinery

There is no information on the effects of the drug on the driver and operating machinery, however, methyldopa can cause drowsiness. Therefore, avoid using drugs when driving and operating machinery.

Drug interaction

should be cautious when methyldopa is used simultaneously with the following drugs:

Other hypertension treatments: may increase the effect of lowering blood pressure, increasing adverse reactions or a specific reaction.

Anesthesia: The dose of anesthetics must be reduced, if hypotension during anesthesia can use vasoconstrictor drug.

Lithi: Increases the toxicity of lithium.

Monoamine inhibitors (Mao): Because of excessive hypotension.

Amphetamine, central nerve stimulants, 3 -round antidepressants.

Because of antagonism to treat hypertension and loss of blood pressure control.

iron hematopsius has: Methyldopa's concentration in plasma and reducing anti -hypertension effects of methyldopa.

Oral contraceptives: because of the increased risk of vascular damage and causing difficulty in blood pressure control.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

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