Agifamcin 300 Agimexpharm treats all tuberculosis, leprosy (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Rifampicin
Ingredient Agimexpharm Pharmaceutical Joint Stock Company

Ingredient

Thành phần cho 1 viên

Composition information	Content
Rifampicin	300mg

Uses

Indications

Agifamcin 300 drug is indicated in the following cases:

Treatment of all tuberculosis including meningeal tuberculosis, often in combination with other tuberculosis drugs such as Isoniazid, Pyrazinamid, Ethambutol, Streptomycin to prevent anti -drug mutant bacilli. For a group of bacteria, according to the 3 -drug regimen, combine Rifampicin with Dapson and Clofazimin. Methicillin and multi -resistance (in combination with staphylococcus a staphylococcus). Rifampicin is active with bacteria of Mycobacterium, especially other tuberculosis, leprosy and mycobacterium bacteria such as M. Bovis, M. Avium. The minimum concentration of inhibitory for tuberculosis bacteria is 0.1–2.0 micrograms/ml. In addition, Rifampicin is a broad -spectrum antibiotic, in vitro has a good effect on Gram -positive and gram -negative bacteria, but the clinical effect has not been confirmed with intestinal bacteria. Rifampicin is very effective for staphylococcus aureus, including penicillin and isoxazyl-Penicillin resistance (with staphylococcus a staphylococcus of S. Epidermidis is also so sensitive). The minimum inhibitory concentration for staphylococcus is 0.008–0.06 mg/ml. Bacterial meninges, gonorrhea and haemophilus influenzae are also very sensitive.

Rifampicin is also used in the treatment of severe staph infections such as endocarditis, pneumonia, bacterial infection and myelitis. When resistant to other antibiotics, rifampicin is used with fusidic acid.

Rifampicin is not cross -resistant to antibiotics and other tuberculosis drugs, but the anti -drug strains grow very fast when using lone rifampicin and abuse. Therefore, it is necessary to use rifampicin very strictly to ensure successful treatment.

The mechanism of action of rifampicin is unlike other antibiotics. Rifampicin inhibits the RNA synthetic enzyme activity depending on the DNA of Mycobacterium bacteria and other bacteria by creating sustainable complexes - enzymes.

pharmacokinetic

absorption

Rifampicin is quickly absorbed through the gastrointestinal tract. When taking the dose of 600 mg, after 2–4 hours, the peak concentration in plasma is 7–9 micrograms/ml. Food slows down and reduces drug absorption.

Distribution

The drug is widely distributed into the tissue and fluid, diffusing into the cerebrospinal fluid when the meninges are inflamed. The drug is placed in both placenta and breast milk. The integral is equal to 0.93–1.6 l/kg. Link with plasmaprotein 80%.

Metabolism

Rifampicin metabolizes in the liver. The drug is quickly reduced to acetyl into active metabolites (25-O-Desacethyl-Rifampicin).

Other metabolites that have been identified as rifampin quinon, desacethyl-rifampin quinon and 3-formyl-rifampin.

Elimination

rifampicin excreted through bile, feces and urine and undergoing the gut -liver cycle. 60–65% of dosage dosage.

About 10%, excreted drugs in the form of unchanged urine, 15% are metabolites that are active and 7% are 3-formyl derivatives no longer active.

Rifampicin's sale time at the beginning is 3–5 hours when used repeated, the selling time is reduced to 2–3 hours. Prolonged sale time in people with liver failure.

Before taking Agifamcin 300 Agimexpharm treats all tuberculosis, leprosy (10 blisters x 10 tablets)

How to use

Agifamcin is used by oral. Rifampicin should be taken at an hunger with 1 cup of full water (1 hour before eating or 2 hours after eating). However, if digestive irritation, can be taken after eating. Take the only medicine once a day.

Dosage

TB treatment

Must coordinate with other tuberculosis drugs such as isoniazid, streptomycin, and ethambutol. Dosage for adults and children: 10 mg/kg, maximum 600 mg, once a day or 2–3 times/week.

Cyeus treatment

Must coordinate with other leprosy medications such as Dapson and Clofazimin.

With a group of patients with many bacteria used continuously 24 months on the following regimen:

From 0 to 5 years old: Rifampicin 150–300 mg x 1 time/month and clofazimin 100 mg x 1 time/month or 100 mg/week x 1 time/week and DASSON 25 mg 1 time/day.

From 6 to 14 years old: Rifampicin 300–450 mg x 1 time/month and Clofazimin 150–200mg x 1 time/month or 150mg/week x 1 time/week and dapson 50–100mg x 1 time/day.

Adults aged 15 and older: Rifampicin 600 mg 1 time/month and Clofazimin 300 mg 1 time/month or 50 mg/day x 1 time/week and dapson 100 mg x 1 time/day.

With a group of people with less bacteria used for 6 months as follows:

From 0 to 8 years old: Rifampicin 150–300 mg x 1 time/month and Dapson 25 mg 1 time/day.

From 6 to 14 years old: Rifampicin 300–450mg x 1 time/month and Dapson 50–100 mg x 1 time/day.

Adults aged 15 and older: Rifampicin 600 mg 1 time/month and dapson 100 mg x 1 time/day.

Prophylactic meningitis

Do Haemophilus Influenzae:

Children under 1 month: 10 mg/kg x 1 time/day x 4 days.

Children from 1 month or more: 20 mg/kg x 1 time/day x 4 days.

Adults: 600 mg x 1 time/day x 4 days.

Do Neisseria Meningitidis:

Children under 1 month: 5 mg/kg x 2 times/day x 2 days.

Children from 1 month or more: 10mg/kg x 2 times/day x 2 days.

Adults: 600 mg x 2 times/day x 2 days.

Treatment of staphylococcus aureus methicillin resistance

Vancomycin intravenously 1 g of 1 g of 1 g, accompanied by oral Rifampicin 600 mg x 12 hours/time and oral sodium fusidate 500 mg x 8 hours/time. The treatment is 2–6 weeks, depending on the infection.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Take activated carbon to increase the removal of the gastrointestinal tract. The positive urinary will increase the elimination of the drug. Hematoma can be effective in some cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Agifamcin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, abdominal pain, nausea, anorexia.

Skin: skin rash, itching attached to the board or not.

Endocrine: Menstrual disorders.

Uncommon, 1/1000

Systemic: headache, dizziness, fatigue, fever.

nerve: Sleeping chicken, loss of air conditioning, difficulty focusing on thoughts.

liver: increased transaminase, alkaline phosphatase, increased serum bilirubin, jaundice and transient porphyrin disorders.

Eyes: Minds of the conjunctivitis.

Rare, ADR

Body: Roll, fever.

Blood: platelets, leukopenia, Eosin hyperpens and hemolytic anemia. digestion: fake colitis.

Skin: BOARD, BOARD.

Respiratory: Difficulty breathing.

urinary: severe renal failure. Mechanical: weak muscle.

Instructions on how to handle ADR

Systemic immune response such as chills, fever, rare during continuous treatment. In the event of a banner or hemorrhage or suddenly reducing the kidney function, it is necessary to stop rifampicin immediately (common in interruption treatment).

Reduce kidney function before using rifampicin does not hinder treatment, but it is necessary to reduce the dose (apart drinks).

Stop using the drug and notify the doctor the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Agifamcin drugs contraindicated in the following cases:

Hypersensitivity to Rifampicin.

Porphyrin metabolism disorders in sensitive people, due to a mechanism related to the enzyme induction Cytochrome P450 in the liver.

Precautions when using

for people with liver failure, must monitor liver function during treatment. Rifampicin induction enzyme should be particularly cautious when taking drugs for patients with potential porphyrin metabolism due to Delta-Amino Levulinic acid activation process. Because the enzyme system in premature babies and newborn babies is incomplete, they only use rifampicin for these objects when really necessary.

Use Rifampicin in combination with Isoniazid and Pyrazinamide will increase the toxicity of the liver. Need to consider the risk of complications and treatment needs.

Must notice the patient in advance that feces, urine, saliva, tears, sweat and other fluids of the body will be red while taking the drug to avoid unnecessary worries. Contact lenses can catch permanent color.

The ability to drive and operate machinery

Medicines that cause headaches, dizziness, fatigue, so be careful to use for drivers and machinery operation.

Pregnancy

If using rifampicin for women who are pregnant in the last 3 months, can bleed due to decrease in prothrombin - Mother and infant. So to avoid bleeding, use more vitamin K for pregnant mothers, after birth and babies.

Animal experiments show that Rifampicin is likely to cause bone deformities. So Rifampicin is only for pregnant women when they have carefully considered risks and needs.

Breastfeeding period

rifampicin eliminated through breast milk, but almost no risk to the baby.

Drug interaction

Rifampicin induction enzyme cytochrome P450 should increase metabolism and excretion. Therefore, reducing the effects of some drugs when used simultaneously.

Drugs should be avoided in combination with rifampicin: isradipin, nifedipin and nimodipin.

The following drugs when in combination with rifampicin need to adjust the dose: contraceptive pill, cyclosporin, diazepam, digoxin, anticoagulant drug dicoumarol, disopyramide, doxycycline, phenytoin, glucocorticoids, haloperidol, ketoconazole, erythromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin, clarithromycin Chloramphenicol, Theophyllline, Verapamil ...

Some drugs when used with rifampicin will reduce the absorption of rifampicin such as antacids, benfonite, clofazimin ... fix by drinking separately by 8–12 hours apart.

In addition, isoniazid and liver toxic drugs when used in combination with rifampicin will increase the risk of toxicity to the liver, especially liver failure.

Storage

temperature below 30 ° C, avoid moisture and light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.