Agifuros 40mg Agimexpharm treat acute pulmonary edema, heart, liver, kidney (10 blisters x 25 tablets)

Dosage form Box of 10 blisters x 25 tablets
Specifications Furosemid
Ingredient Hyper calcium, hypertension, pulmonary edema

Ingredient

Composition information	Content
Furosemid	40mg

Uses

indications

Agifuros 40mg drug is used in the following cases:

Acute pulmonary edema;

Supplied heart, liver, kidney and other edema;

Hypertension when kidney damage;

Hypercalcemia.

Pharmacy

Furosemid is a sulfonamid diuretic that is a strong, fast, dosage -dependent effect group. The drug acts on the upward branch of the Henle straps, so it is classified as a group of diuretics. The main mechanism of action of Furosemid is to inhibit the Na+, K+, 2CI-2 -CI transport system in the thick segment of the branch on the Henle straps, increasing the excretion of these electrolytes accompanied by increased water export exercises. There is also an increase in Ca ++ and Mg ++ elimination.

The diuretic effect of strong drugs, thus led to the effect of lowering blood pressure, but often weak. In patients with pulmonary edema, Furosemid causes increased venous volume, thus reducing the money burden for left ventricle before seeing the diuretic effect.

pharmacokinetic

absorption

Furosemid is good orally absorbed by oral, diuretic effects appear quickly after 1/2 hours, reaches the maximum concentration after 1-2 hours and maintains the effect of 4-6 hours. Anti -hypertension effect is longer. For patients with severe edema, the bioavailability of the drug is reduced, possibly due to the direct effect of reducing the absorption of the gastrointestinal tract. Furosemid's absorption can be extended and can be reduced by food.

Distribution

up to 99 % Furosemid attaches to plasma albumin. The freelance Furosemid part (not attached) is higher in people with heart disease, kidney failure and cirrhosis.

Furosemid can pass the placenta and distribute into breast milk.

Metabolism, excretion

Furosemid is excreted mainly in urine, mostly in the form of non -metabolic. Half life eliminates from 30 minutes to 120 minutes in normal people, prolonged in infants and patients with liver and kidney failure.

Before taking Agifuros 40mg Agimexpharm treat acute pulmonary edema, heart, liver, kidney (10 blisters x 25 tablets)

How to use

Agifuros 40mg is used orally. Should take the tablet with a full glass of water.

Dosage

Adults and children over 12 years old:

Treatment of edema:

The oral dose is usually 40mg/day. The mild case may be used by 20mg/day or 40mg of Japan.

Furosemid is not the main drug to treat hypertension and may be lungs suitable for other anti -hypertension drugs to treat hypertension in people with kidney damage.

Take 120mg/day, take 1 time or divide into 2 or 3 small doses.

Dosage calculated by weight of children, so should choose the appropriate form of preparation for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Management: In return, the amount of water and electrolytes lost.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Agifuros 40mg, you may experience unwanted effects (ADR).

The unwanted effect mainly occurs during high doses, the most common is water and electrolyte imbalance, especially in people with liver failure, kidney failure, after high doses and prolonged doses. The signs of electrolyte imbalance include headache, hypotension, dizziness, dizziness, visual disorders, cramps, dry mouth, thirst, weak, tired, sleepy, sleepy, sleeping, urinating, arrhythmia and digestive disorders.

Reducing blood volume and dehydration may occur, especially in the elderly. Because of the shorter acting time, the risk of hypokalemia of Furosemid may be less than the diuretic benefits. Unlike thiazid, Furosemid increases excretion of calcium in urine and renal calcium infection that has been notified in children.

Very common, ADR> 1/10

Vascular disorders: Hypotension (may show signs and symptoms such as dizziness, feeling of pressure in the head, headache , drowsiness, weakness, vision disorders, mouth dryness). ADR> 1/100

circulating: Reducing blood volume in case of high doses of treatment. Hypotenary pressure vertical.

Gastrointestinal disorders: Dry mouth , thirst, nausea, vomiting, peristalsis, diarrhea, constipation. Hyperglycemia. muscle.

Skin and tissue disorders subcutaneously: skin rash, paresthesia, urticaria, itching, hemorrhage, peeling dermatitis, sensitive reaction to light (may be serious). Chemistry: Hypergaric glucose, urinary glucose (maybe less than the diuretic benefits). Deafness may not recover, especially in patients taking the same drugs that are also toxic to ears. and urinary tract: acute renal failure.

Blood disorders and lymphatic systems: hemolytic anemia, leukopenia, thrombocytopenia.

Check regularly electrolytes. Supplement potassium or use with diuretics to keep potassium when the patient is at high risk of hypokalemia.

Dose reduction or stop treatment if ADR is medium or severe.

Warnings

Before using the drug, you need to read the instructions carefully and refer to the information below.

Contraindicated

The drug is not used in the following cases:

Sensitive to Furosemid and with sulfonamid derivatives, such as sulfamid to treat diabetes as well as any ingredients of the drug;

electrolyte disorders (severe hypoglyc sodium, severe hypokalemia, hypoglycemia), dehydration or hypotension.

Money condition, liver coma with cirrhosis .

Animal or renal failure due to toxic drugs to the kidneys or liver.

Addison disease.

Digitalis poisoning.

Lactating women.

Be cautious when using

Conditions to be treated before using Furosemid:

Hypotension.

Reducing blood volume.

Severe electrolyte disorders - Especially hypokalemia, hypoglyc sodium and acid -base disorders.

Dosage adjustment status:

Patients with reduced blood protein such as nephrotic syndrome should be carefully adjusted (reducing furosemid, increasing the risk of toxicity on the ear).

Cases need to be cautious:

impaired liver function.

impaired kidney function and liver syndrome.

diabetes.

Elderly patients.

Patients with prostate hypertrophy or difficult urination because they can promote urination.

Gout patients (increased risk of hyperuricemia in the blood).

Patients are at risk of hypotension.

Clinical monitoring requirements:

Hematopoiia, if occurred, stop Furosemid immediately.

liver damage.

The specific reaction of Furosemid.

Request monitoring of test indicators:

Monitor electrolytes, especially potassium and sodium.

Kidney function: Bun (Blood Urea Nitrogen test) regularly in the first few months of treatment, then periodically check. The concentration of creatinine and urea in the blood tends to increase during treatment.

Cholesterol and triglycerides in the blood may increase but often return to normal within 6 months from the beginning of using Furosemid.

Should stop Furosemid before testing Glucose.

This drug contains lactose: Patients with rare genetic problems are galactose intolerance, lapp lactase deficiency or glucose-galactose abutments should not be used.

The ability to drive and operate machinery

There is no information on the effect of the drug on the driver and operating machinery, however, should be cautious because during the time of taking the drug may experience side effects: headache, hypotension and cramps. The drug can reduce alertness, reduce the ability to drive and operate machinery.

Pregnancy and lactation

Pregnancy

Thiazid, thiazid diuretics and diuretics are even through the placenta fence into the fetus and cause water and electrolyte disorders and electrolytes for the fetus. With thiazid and conducting many cases of platelet reduction in newborns have been notified. This risk also appears after the use of diuretics such as Furosemid and Bumetamid. Furosemid should only be used during pregnancy when the benefits are out of risk.

Breastfeeding period

Using Furosemid, which is at risk of breastfeeding. Furosemid is not recommended for use during breastfeeding.

Medicine interaction

Hydrophermor medications: increase the effect of lowering blood pressure. If coordinated, the dose should be adjusted. Especially when combined with Angiotensin transfer enzyme inhibitors, blood pressure may be severe.

Arrhythmic treatment (including amiodaron, disopyramide, flecanaid and sotalol): The risk of heart poisoning (ferinemia caused by Furosemid). The effects of lidocaine, tocainide or mexiletin may be opposed by Furosemid.

Prolonged drug -related drugs: Heart toxicity can increase due to Furosemid causing hypoache or hypoglycemia.

cardiac glycosides: increases the toxicity of glycosides on the heart due to furosemids that lower blood potassium. Need to monitor blood potassium and electrocardiograms.

Vascular vasodilation: Enhance the hypotension effect with moxisylyte (thymxamin) or hydralazin.

Renin inhibitors: Aliskiren reduces plasma concentrations in Furosemid.

Nitrate groups: Improve the effectiveness of hypotension.

Other diuretic drugs: increasing the effects of Furosemid, increasing the risk of hypokalemia with thiazid. Potassium -keeping pills can reduce potassium loss when using Furosemid (beneficial).

Antibiotics: Cephalosporin increases the toxicity of the kidneys, aminoglycosides increase toxicity to the ears and kidneys; Polymyxins and vancomycin increase toxicity to the ears. Furosemid can reduce the serum concentration of vancomycin after heart surgery.

Mushroom treatment: Increased risk of hypokalemia with amphotericin.

Lithi salt: increases the level of lithium in the blood, can be toxic. Should avoid using if you cannot monitor the concentration of blood lithium.

Non -steroid anti -inflammatory drugs: increases the risk of toxicity to the kidneys, reducing diuretic effects. Indometacin and Ketorolac may disable the influence of Furosemid. In patients with dehydration or hypoglycemia, nonsteroidal anti -inflammatory can cause acute kidney failure.

corticosteroid: Increased risk of reducing potassium, antagonism with diuretic effects.

salicylate: Effective can be enhanced by Furosemids.

Diabetes treatments: Reduce the effect of lowering blood glucose of diabetes treatment, need to monitor and adjust the dose.

Non -reducing muscle relaxants: increase muscle relaxation effect.

Anticoagulant: Increases anticoagulant effects.

Sucralfat: may reduce the intestinal absorption of Furosemid, these two should be taken at least 2 hours away.

Cholestyramin, Colestipol: Reduce the absorption of Furosemid, these 2 should take 2-3 hours.

cisplatin: Increases toxicity with ears and kidneys.

Anti -epileptic drugs: Phenytoin reduces the effect of Furosemid, carbamazepine reduces sodium blood.

Anti -psychotic drugs: Furosemid causes hypoemia to increase the risk of toxicity on the heart. Avoid using simultaneously with pimozid. Increased risk of ventricular arrhythmia with amisulprid or Serttindole. Enhance the effectiveness of hypotension with phenothiazine.

Antidepressant drugs: Improve the effectiveness of hypotension with imao. Increasing the risk of posture hypotension with tricyclic antididepressants. Can increase the risk of hypokalemia with ReBoxetine.

Chloral Hydrate: causes blushing syndrome, tachycardia, hypertension, sweating.

Probenecid: reduces the kidney clearance of Furosemid and reduces the diuretic effect.

Central neurological inhibitors (Clopromazin, Diazepam, Clonazepam, Halothan, Ketamin): Increases the effect of reducing blood pressure.

Central neurological stimulants (CNS) (drugs used for ADHD treatment): Hypotension increases the risk of ventricular arrhyths.

levodopa : Improve the effectiveness of hypotension with levodopa.

Aldesleukin : Improve the effectiveness of hypotension with Aldesleukin.

estrogen and progestogen: antagonistic diuretic effects.

Prostaglandin: Improve the effectiveness of hypotension with Alprostadil.

Sympathetic substance: Increased risk of hypokalemia with high doses of beta2 sympathetic substances (such as Bambuterol, Femoterol, Salbutamol, Salmeterol and Terbutalin).

Theophylllin: Improve the effectiveness of hypotension.

Anesthesia: General anesthetic may increase the hypotension effect of Furosemid. The effect of poisonous plants can be enhanced by Furosemid.

Alcohol: Improve the effectiveness of hypotension.

Laxatives: Increases the risk of potassium loss.

Licorice: Excess amounts may increase the risk of hypokalemia.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

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