Agimdogyl Agimexpharm medicine for acute and chronic oral infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Metronidazole, Spiramycin
Ingredient Agimexpharm

Ingredient

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Composition informationContent
Metronidazole125mg
Spiramycin750000iu

Uses

indications

Agimdogyl drug is indicated in the following cases:

  • Treatment of acute, chronic or recurrent oral infections, especially teeth, inflammation, tissue inflammation surrounding jaw bone, inflammation around the body of the tooth, gingivitis, stomatitis, periodontitis, ear inflammation, gland inflammation of the jaw. Combining spiramycin, antibiotics in macrolid and metronidazol, antibiotics of 5-nitro-imidazol family, special treatment of dental infections.

    Related to Spiramycin:

    Spiramycin is an antibiotic macrolid with antibacterial spectrum similar to antibacterial spectrum of erythromycin and clindamycin.

    The drug has the effect of bacteria in bacteria that are dividing cells. In serum concentrations, the drug has a bactericidal effect, but when it reaches the concentration of the drug can kill bacteria and prevent protein synthetic bacteria.

    Spiramycin's antibacterial activity on bacteria often causes oral diseases as follows:

    Often sensitive bacteria: Bacterial streptococcus is not group D, pneumococcal, meninges, Bordetella pertussis, Actinomyces, Corynebacteria, Chlamydia, Mycoplasma.

    Non -sensitive bacteria: staphylococcus, gonococcal bacteria, streptococcal group d, haemophilus influenzae.

    resistance bacteria (mic> 8mcg/ml): Hieu bacilla when grams.

    Related to Metronidazol:

    Metronidazol is a derivative 5 - nitro - imidazole, has a broad spectrum on virgin animals such as amoeba, giardia and anaerobic bacteria.

    The mechanism of action of Metronidazol is not very clear. In parasites, group 5 - nitro drugs are reduced into toxic intermediaries with cells.

    These substances bind to the twisted structure of the DNA molecule that breaks these fibers and eventually causes dead cells. The effective average concentration of metronidazol is 8 micrograms/ml or lower for most protozoa and sensitive bacteria.

    Minimum concentration of inhibition (mic) sensitive strains about 0.5 micrograms/ml.

    A strain of bacteria when isolated is considered to be sensitive to the drug when the mic does not exceed 16 micrograms/ml.

    Metronidazol's antibacterial activity on bacteria often causes oral diseases as follows:

    Usually sensitive bacteria (mic: 0.8 - 6.2 mcg/ml): Aaerobic bacilli: Clostridium, C. perfringens, Bifidobacterium Bifidum, Eubacterium, Bacteroides Fragilis, Melaninogenicus, Pneumosintes, Fusobacterium, Veillonella, peptostreptoccus, peptostococc Peptococcus.

    Non -sensitive bacteria: Propionibacterium acnes, Actinomyces, Arachnia.

    resistance bacteria: anaerobic bacillus, aerobic bacillus.

    The force of force: The average mic of 2 active ingredients when combined shows the inhibition of some sensitive bacteria strains.

    pharmacokinetics

    related to spiramycin:

    absorption

    Spiramycin is not completely absorbed in the digestive tract. Oral drugs are absorbed about 20-50% of the dose of use. The peak concentration of plasma is achieved within 2-4 hours after drinking, taking Spiramycin when there is food in the stomach that greatly reduces the bioavailability of the drug. Food reduces about 70% of the maximum concentration of the drug in the serum and makes the peak time from 2 hours.

    distribution

    Spiramycin is widely distributed throughout the body. The drug reaches high concentrations in the lungs, tonsils, bronchial and sinuses. Spiramycin is less penetrated into the cerebrospinal fluid.

    Serum concentration has a bactericidal effect in the range of 0.1 - 3.0 micrograms/ml and the drug concentration in tissue has a bactericidal effect in the range of 8 - 64 micrograms/ml.

    Elimination

    Spiramycin oral drugs have half a short distribution (10.2 ± 3.72 minutes).

    Half of life is 5 - 8 hours on average. The concentration of drugs in bile is 15-40 times larger than the serum concentration.

    After 36 hours, only about 2% of the total dose is found in the urine. Spiramycin is also excreted through breast milk with high concentrations.

    Related to Metronidazol:

    absorption - distribution

    Metronidazole usually absorbs fast and completely after drinking, reaching a plasma concentration of about 10 micrograms/ml about 1 hour after taking 500 mg.

    The linear correlation between the dose and plasma concentration takes place within the dose range from 200-2000 mg.

    Dosage repeated every 6 - 8 hours will cause the accumulation of the drug.

    Metronidazol's half -life in plasma is about 8 hours and an integral distribution of water volume in the body (0.6 - 0.8 liters/kg).

    about 10 - 20% of the drug is associated with plasma proteins. Metronidazole penetrates well into tissues and fluids, into saliva and breast milk. The concentration of treatment is also achieved in cerebrospinal fluid.

    transformation

    metronidazole metabolizes the liver into hydroxy metabolites and glucuronic acid complexes, and eliminates through urine partially in the form of glucuronid. The metabolites still have some pharmacological effects.

    Elimination

    Half lifetime eliminates average in plasma about 7 hours. The half -life of hydroxy metabolites is 9.5 -19.2 hours in patients with normal kidney function.

    Over 90%of oral doses are eliminated through the kidneys for 24 hours, mainly hydroxy metabolites (30-40%), and acid form (10 - 22%). Under 10% excreted in the form of mother quality. About 14% of the dose of elimination through feces.

    In patients with renal failure, the half -life of the mother does not change, but the half -life of hydroxy metabolites lasts 4 to 17 times. Metronidazol metabolism may be affected much, when severe liver failure. Metronidazole can be eliminated from the body as effective as a clinic.

    • Before taking Agimdogyl Agimexpharm medicine for acute and chronic oral infections (2 blisters x 10 tablets)

    How to use

    Agimdogyl drugs for oral, oral at meals.

    Dosage

    adults

    Common doses used in adults: Dosage of 2 capsules/ x 2-3 times/ day. Severe cases (attack treatment) do the dose may be up to 8 tablets/day.

    Children

    Common dose used in children 6-10 years old: Take 1 capsule/ time x 2 times/ day.

    Common dose in children 11-15 years old: Take 1 tablet/time x 3 times/day.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Overdose:

  • In -Spiramycin -related disorders: There is no toxic dose known for Spiramycin. The gastrointestinal signs at an expected overdose are nausea, vomiting, diarrhea.

    • Disorders related to metronidazol: In case of taking a single dose up to 15 g has been promoted. Symptoms include nausea, vomiting and loss of air conditioning. The nerve effect of convulsions, peripheral neuritis has been reported after 5 to 7 days of dosage 6 - 10.4 g 2 days/time.

    Management:

  • No specific antidote.
  • In case of overdose, symptomatic treatment and support. Metronidazole can be eliminated from the body as effective as a clinic.

    • What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    When using Agimdogyl drug, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Digestive system: indigestion, anorexia, nausea, vomiting, diarrhea, epigastric pain, abdominal pain, constipation, dry mouth, with a very uncomfortable metal taste in the mouth.
    • all body: headache.

    Uncommon, 1/1000

  • Skin: blistering, skin rash, urticaria.
    • Blood: leukopenia, loss of leukocytes.

    Central nerve: epilepsy, peripheral multiple nerve disease, headache.

    urinary tract: dark urine. digestive: acute colitis.

  • body: fatigue, sweat, staggering; Anaphylactic reaction, superinfection (when using spiramycin for a long time).

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Agimdogyl drug contraindicated in the following cases:

  • People with a history of hypersensitivity to Spiramycin, erythromycin, Metronidazol, other chatnitro-imidazol leads and/or other ingredients of the drug.
  • Children under 6 years old (due to inappropriate formation).

    • Be cautious when using

    involving Spiramycin: Be careful when taking drugs for people with liver dysfunction, because the drug can be toxic to the liver.

    Related to Metronidazol:

  • Metronidazol has the effect of inhibiting alcohol Dehydrogenase and other alcohol oxidation enzymes. Disulfiram mild reaction such as hot face, headache, nausea, vomiting, abdominal spasms and sweating occurred in patients drinking alcohol while being treated with Metronidazol.

    • Metronidazole can cause immobility of treponema pallidum to create a false positive reaction of the Nelson test.

    The ability to drive and operate machinery

    should warn patients about the risk of dizziness, headache or convulsions of the drug and suggest that they should not drive or operate machinery if this disorder is.

    Pregnancy

    Spiramycin and Metronidazol both go through the placenta.

    Although Spiramycin does not cause a stroke when used for pregnant people, there has been no notice about causing monsters due to the use of metronidazol; However, there are also a number of studies that have announced the risk of monitoring increases when taking the drug in the first 3 months of pregnancy. Therefore, it is not advisable to use during the first time of pregnancy, unless it is required to use but must follow the doctor's instructions.

    Lactation period

    spiramycin and metronidazole are excreted through breast milk so it should be stopped breastfeeding while taking the drug.

    Medicinal interaction

    involving Spiramycin: Concentrated with oral contraceptive medicine will cause loss of conception.

    Related to Metronidazol:

  • Metronidazol increases the effect of anticoagulant oral drugs, especially Warfarin, so avoid use at the same time.
  • metronidazol has a disulfiram -style effect. So do not use these two drugs simultaneously to avoid nervous effects such as psychosis, confusion.

    • Concomplified Metronidazol and Phenobarbital to increase metronidazol metabolism, so Metronidazole excreted faster.

  • Use Metronidazol for patients who are high in blood lithium concentration (because they are using lithium) will increase serum lithium concentration, toxic.

    • metronidazole increases the effect of vecuronium is a non -reducing muscle relaxant.

    Storage

    temperature below 30 ° C, avoid moisture and light.

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