Agimetpred 4 Agimexpharm anti -inflammatory, treating nephrotic syndrome (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone
Ingredient Nephrotic syndrome, erythematosus lupus, allergic disease, bronchial asthma, ulcerative colitis, rheumatoid arthritis

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

indications

Agimetpred 4 drug is indicated in the following cases:

Methylprednisolon is indicated in nonspecific therapy that requires anti -inflammatory and immunodeficiency effects of glucocorticoid for: rheumatoid arthritis, systemic erythema lupus, some inflammatory forms; Pacific artery and inflammation around the artery, sarcoid disease, bronchial asthma, chronic ulcerative, hemolytic anemia, granulocytopenia, and severe allergens including anaphylaxis; In the treatment of cancer, such as acute Leukemia disease, lymphoma, breast cancer and prostate cancer. Prednisolon, has anti -inflammatory, anti -allergic and immunosuppressive effects.

Due to methylation Prednisolon, the effect of corticosteroids metabolizes salt has been excluded, so there is very little risk of keeping Na+ and causing edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon; 4 mg methylprednisolon is valid as 20 mg of hydrocortison.

Inflammation, any disease is characterized by the escape and absorbent of the white blood cells into the tissue (position) of inflammation. Glucocorticoids inhibit these phenomena. Glucocorticoid uses systemic sugar to increase the number of neutrophils and reduce the number of lymphocytes, eosin leukocytes, single -blood leukocytes in peripheral blood.The increase in neutrophils is due to an increase in the mobilization of neutral leukocytes from the bone marrow reserves, because their half -life in the blood circulation is prolonged and due to vascular drainage and additional infection to the site of inflammation. Perhaps this ultimate cause is one of the main mechanisms of anti -inflammatory effects of glucocorticoid. The reduction of the number of lymphocytes, eosin leukemia and single blood cells in the blood circulation is the result of their transportation from blood vessels into lymphoma.

Glucocorticoid also inhibits the function of lymphocytes and tissue macrophages. Their response ability with antigens and stool cockroaches decreases. The effects of glucocorticoids on special macrophages, limiting their macrophages, limits the ability to kill microorganisms and limit the production of Interferon - Gama, Interleukin - 1, fever, collagenase and elastase enzymes, whemola causing necrosis of swelling and plasminogen active substance. Glucocorticoid acts on lymphocytes that reduce the production of Interleukin - 2.

In addition to the effect of leukemia, glucocorticoid also affects inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation A2. Glucocorticoid increases the concentration of some membrane phospholipids that inhibit prostaglandin synthesis. Corticosteroids also increase lipocortin levels, which is a protein that reduces phospholipids, the substrate of phospholipase A2. Finally, glucocorticoid reduces the appearance of cyclooxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin.

Glucocorticoid reduces capillary base due to inhibiting the activity of kinine and bacterial internal toxins and reduces the amount of hydrophilia by base leukemia.

The immunosuppressive effect of glucocorticoid is largely due to the above effects. Large doses of drugs can reduce antibodies, and the average dose does not have this effect (for example, 16 mg/day methylprednisolon).

In some cases, glucocorticoids kill lymphocytes - T. T. Normal T cells in peripheral blood have resistance to the cell death effect of glucocorticoid. However, unusual lymphocytes, including some cancer cells, may be much more sensitive.

The anti -lymphatic effects are a chain of lymphocytes activation. These anti -lymphocytes are exploited in chemotherapy Leukemia lymphoma and lymph nodes.

corticosteroid is effective in bronchial asthma, proving the role of inflammation in immunological pathogens of this disease. Always have to start treatment with beta stimulants. In severe severe asthma attacks, Glucocorticoid injection is required. However, these asthma people still need to continue using inhaled corticosteroids. Often treating less severe acute asthma attacks with short stages of glucocorticoid. The inhibition of adrenal gland function usually goes out within 1 to 2 weeks.

In the treatment of chronic bronchial asthma that other measures are ineffective. The long -term use of glucocorticoids may be used with the lowest doses to save the patient's life and need to be cautious when planning to stop the drug.

Glucocorticoid is widely used in the treatment of many different diseases and is a main therapy in the treatment of more severe diseases such as systemic erythematosus lupus and many inflammatory disorders such as cylinders around artery, Wegener, and giant cell artery.

For severe disorders, the glucocorticoid dose begins to be sufficient to reduce the disease quickly and to minimize tissue lesions then a reinforcement stage with a single dose every day, and gradually reduce to the minimum dosage to work. In rheumatoid arthritis, the starting dose starts relatively low. During the exacerbation, the dose may be higher, then gradually decreases quickly.

In children with chronic arthritis with complications that threaten life, sometimes use methylprednisolon in attacking therapy.

Glucocorticoid works well in some people with chronic ulcerative and Crohn disease. Glucocorticoid is the leading therapy for nephrotic syndrome. In glomerulonephritis, the application of glucocorticoid therapy for every day for 8 to 10 weeks, then gradually decreases the dose for 1 to 2 months.

can treat the manifestations of short -term allergies, such as hay sauce, serum disease, pain, contact dermatitis, drug reaction, bee and nerve edema - vascular with additional glucocorticoids for the main therapy.

In anemia dissolved immune machine, if the main cause is not cured or if an emergency intervention is needed, glucocorticoid is a basic therapy.

In immunity is anemia, if the main cause is not cured or if an emergency intervention is needed, Glucocorticoid is a basic therapy.

Treatment of sarcoid disease with corticosteroids. Due to the risk of secondary tuberculosis, patients who have tuberculosis must be treated for tuberculosis prevention.

Dynamic pharmacokinetics

bioavailability is approximately 80%. Plasma concentration reaches a maximum of 1-2 hours after taking the drug. Effect time 30 - 36 hours after drinking.

methylprednisolon is metabolized in the liver, like metabolism of hydrocortison, and metabolites are excreted through urine. Half life is approximately 3 hours.

Before taking Agimetpred 4 Agimexpharm anti -inflammatory, treating nephrotic syndrome (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Determine the dose for individuals.

The starting dose

Take 6 - 40 mg of methylprednisolon per day. The necessary dose to maintain the desired treatment is lower than the dose needed to achieve the initial effect, and must determine the lowest dose that can be achieved by the need for gradually reducing the dose step by step until the signs or symptoms increase.

When you need to use big doses for a long time, apply medication therapy the day after control of the process of the disease, it will be less ADR because there is a recovery time between each dose.

In a daily -way therapy, using a single dose of methylprednisolon every 2 days, in the morning in the span of natural secretion glucorticoid.

Acute asthma attack

methylprednisolon 38 to 48 mg daily, for 5 days, then additional treatment can be added at lower doses in a week. When from acute attacks, methylprednisolon is gradually reduced.

rheumatoid arthritis

The starting dose is 4 to 6 mg of methylprednisolon per day.

During exacerbation, higher doses: 16 to 32 mg/day, then gradually decreases.

Chronic arthritis in children with life -threatening complications

Sometimes methylprednisolon is sometimes used in attack therapy, at a dose of 10 to 30 mg/kg/time (usually used 3 times).

Chronic ulcerative ulcerative

Mild disease: Holding (80 mg).

Severe exacerbations: oral (8 to 24 mg/day).

Nephropathy syndrome

Start, use daily methylprednisolon doses of 0.8 to 1.6 mg/kg for 6 weeks, then gradually reduce the dose for 6 to 8 weeks.

Immune hemolyticemia

Take methylprednisolon daily 64 mg for 3 days. Methylprednisolon must be treated at least 6-8 weeks.

Sarcoid disease

methylprednisolon 0.8 mg/kg/day, to improve the disease.

Low maintenance dose: 8 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

When using high doses of fruit for a long time, increase adrenal gland energy and inhibit the adrenal glands may occur. In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using AgimetPred 4 you can experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: Insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

Neurosomal and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibition, adrenal, slow growth, glucose intolerance, hypokalemia, alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

digestion: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis. nervous - muscle and bone: muscle weakness, osteoporosis, fracture.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Agimetpred 4 drug contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Systemic fungal infection. Skin damage caused by viruses, fungi or tuberculosis.

Peptic ulcer.

Severe infections, except for bacterial shock and meningitis.

is using a living virus vaccine.

Be cautious when used

Use carefully in people with osteoporosis, new people connecting blood vessels, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccinations.

The ability to drive and operate machinery

Precautions when taking drugs for drivers and operating machinery because drugs can cause dizziness, nerves are easily agitated, mental disorder, headache, mood change, delirium, hallucinations.

Pregnancy

For extension of body corticosteroids for mothers can lead to mitigation of the babies of newborns. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding period

Non -contraindication corticosteroids for nursing mothers.

Drug interaction

methylprednisolon is a cytochrom P450 enzyme induction, and is the substrate of the P450 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketocon, ketocmazepin Rifampicin.

Phenytoin, phenobarbitol, rifampin and diuretics, reduced potassium can reduce the effectiveness of methylprednisolon.

methylprednisolon may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Storage

in a dry place, less than 30 ° C, avoid light.

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