Agimexpharm supertrim powder pesticides treat infections caused by sensitive bacteria (30 packs)

Dosage form 30 package box
Specifications Sulfamethoxazole, trimethoprim

Ingredient

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Composition information	Content
Sulfamethoxazole	400mg
Trimethoprim	80mg

Uses

Indications

Supertrim 400mg Agimexpharm is indicated for use in cases of infection treatment caused by bacteria sensitive to sulfamethoxazol and trimethoprim:

Urinary tract infections - genitals: urinary tract inflammation, prostatitis.

Chronic urinary tract infections, relapse in adult women.

Respiratory infections: Acute bronchitis, acute pneumonia or acute otitis media in children, acute sinusitis in adults.

Gastrointestinal infections: dysentery, typhoid fever.

Pharmacology

Supertrim is a mixture of sulfamethoxazol and trimethoprim.

sulfamethoxazol is a sulfonamide, inhibiting competition in bacterial folic acid synthesis.

trimethoprim is a derivative of pyrimidine, inhibiting the specific enzyme dihydrofolate reductase of bacteria.

Combining trimethoprim and sulfamethoxazol so that inhibits two consecutive stages of folic acid metabolism, thus effectively inhibits the synthesis of purin, thymin and final DNA of bacteria. This serial inhibition has bactericidal effects. This co -mechanism also resists the growth of anti -drug bacteria and makes the drug work even when bacteria resist each ingredient of the drug.

The following microorganisms are often sensitive to drugs: E. Coli, Klebsiella Sp., Enterobacter sp., Morganella Morganii, Proteus Mirabilis, Proteus Indol, including P. Vulgaris, H. Influenzae (including Ampicilin antigen strains), S. Pneumonia, S. Pneumonia Flexneri and Shigella Sonnei, Pneumocystis Carinii.

Supertrim has some effects on Plasmodium falciparum and toxoplasma gondii.

Dynamic pharmacokinetics

The drug is quickly absorbed through the digestive tract.

distributed in many tissues and fluids including kidney, liver, lung, bronchial, saliva, eye water, prostate and vaginal fluid.
Elimination mainly through the kidneys through glomerular filtration and a little excretion in the biliary tract.

Before taking Agimexpharm supertrim powder pesticides treat infections caused by sensitive bacteria (30 packs)

How to use

oral powder 400mg orally.

Dosage

Dosage in case of urinary - genital infections:

Adults: Take 2 packs of 2 times/day (12 hours apart) for 10 days.

or a single dose of 4 packs, but the minimum treatment for 3 days or 7 days seems more effective.

Children: Take 40 mg Sulfamethoxazol + 8 mg trimethoprim/kg/time x 2 times/day (12 hours apart) for 10 days.

Rehabed chronic urinary tract infections (adult female): Take 1/2 pack daily or take 1-2 packs/time in just 1 or 2 times per week.

Dosage in case of respiratory infections:

Excavity of chronic bronchitis in adults: Take 2-3 packs x 2 times daily, for 10 days.

Acute otitis media, acute pneumonia in children: Take 40mg Sulfamethoxazol + 8mg Trimethoprim/kg for 24 hours, divided into 2 times (12 hours apart) for 5 - 10 days.

Dosage in case of gastrointestinal infections:

dysentery:

Adults: Take 2 packs of 2 times/ day (12 hours apart) for 5 days.

Children: Take 40 mg of sulfamethoxazol + 8 mg trimethoprim/kg for 24 hours, divided into 2 times (12 hours apart) for 5 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Hematopoiia and jaundice are late for overdose. Inhibition.

Handling: Causing vomiting, gastric wash.

Urine acidification to increase trimethoprim elimination. If signs of marrow inhibition, patients need to use leucovorin (folinic acid) 5 - 15 mg/day until hematoma recovery.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Supertrim 400mg Agimexpharm, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Fever.

digestive: Nausea, vomiting, diarrhea, tongue inflammation.

Skin: itching, foreigner.

Uncommon, 1/1000

Blood: Eosin hypernagus, leukopenia, neutropenia, hemorrhage.

skin: urticaria.

rare, ADR

Body: Anaphylaxis, serum disease.

blood: huge red blood cell anemia, hemolytic anemia, thrombocytopenia, granulocytosis and all bloody reduction. liver: jaundice, cholestasis in the liver, liver necrosis.

Metabolism: hyperkalemia, hypoglycemia.

Mental: Illusion. Genital - Urology: kidney failure, interstitial nephritis, kidney stones.

ears: tinnitus.

Instructions on how to handle ADR

Use folic acid 5 - 10 mg/day can avoid ADR due to folic acid deficiency without reducing antibacterial effects. It should be noted that folic acid -deficient body is not fully reflected through serum folic acid levels.

The risk of hyperkalemia also occurs in the common dose and should be considered, especially when used simultaneously other drugs that increase potassium or in the case of renal failure.

Patients need to be instructed to drink enough water to avoid crystallized drugs into gravel. Do not expose to avoid light sensitivity.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Supertrim 400mg Agimexpharm 30 packs x 1.6g contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Severe renal failure without monitoring plasma concentrations.

Patients are determined to be huge red blood cell anemia due to folic acid deficiency.

Pregnant and lactating women.

Children under 2 months of age.

Caution when using

Renal function decreased.

Salt is prone to folic acid deficiency like elderly patients and when taking high doses for a long time.

dehydration. malnutrition.

trimethoprim and sulfamethoxazole can cause hemolytic anemia in people with a deficiency G6PD.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Not used for pregnant women.

breastfeeding period

Not used for breastfeeding women.

Drug interaction

Timeted with special diuretics thiazid increases the risk of thrombocytopenia in the elderly.

sulfonamid can inhibit protein and excreted through the kidneys of methotrexate and thus reduces the elimination, increasing the effects of methotrexate.

Supertrim simultaneously with Pyrimethamine 25 mg/week increases the risk of huge red blood cell anemia.

Supertrim inhibits phenytoin metabolism in the liver, capable of increasing the effect of phenytoin.

Supertrim can prolong prothrombin in patients using warfarin.

Storage

temperature below 30 ° C, avoid moisture and light.

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