Agimfast 60 Agimexpharm treats allergic rhinitis, indefinite urticaria (2 blisters x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Fexofenadine
Ingredient Rhinitis, allergic rhinitis, atopic dermatitis, contact dermatitis, stuffy nose

Ingredient

Composition information	Content
Fexofenadine	60mg

Uses

indications

Agimfast drugs are indicated in the following cases:

Treatment of allergic rhinitis symptoms such as sneezing, runny nose, itchy nose, itchy palate and throat, itchy eyes and tears, chronic urticaria.

Pharmacological

Fexofenadin is a second -generation antihistamine drug, which has a specific antagonistic and selective effect on peripheral H1 receptors. The drug is an active metabolitus of terfenadin but no longer toxic to the heart due to not inhibiting potassium channels associated with myocardial cycles.

Fexofenadin has no significant effect on acetylcholin antagonism, dopamine antagonism and has no effect of inhibiting receptors of Alpha - or beta - adrenergic. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to the slow -attached drug into the H1 receptor forming a solid and separate complex.

Dynamic pharmacokinetics

absorption: good absorption drug when used orally. After taking a 60 mg tablet, the blood peak concentration is about 142 nanogam/ml, achieved after 2-3 hours. Food reduces the peak concentration in plasma by about 17% but does not slow down the time to reach the peak concentration of the drug.

Distribution: The ratio of the plasma protein of the drug is 60 - 70% mainly with albumin and alpha - Glycoprotein acid. The distribution volume is 5.4 - 5.8 liters/kg. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the brain barrier.

Metabolic: approximately 5% of the dose of the drug is metabolized. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances. 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

Elimination: Half of the excretion of Fexofenadin is about 14.4 hours, longer in people with kidney failure. The drug excreted mainly in feces (about 80%), 11 - 12% of the dose is eliminated in the urine in the form of constant.

Before taking Agimfast 60 Agimexpharm treats allergic rhinitis, indefinite urticaria (2 blisters x 10 tablets)

How to use

Take oral use.

Dosage

adults and children> 12 years old: take 1 tablet/ time x 2 times/ day.

The starting dose for people with kidney failure: is only 1 tablet/ 24 hours.

The elderly and patients with liver failure: No need to reduce the dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling: Using conventional measures to remove the drug that has not been absorbed in the digestive tract. Support support and treatment.

Hemolysis reduces the concentration of drugs in the blood (1.7%). There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Agimfast 60, you may experience unwanted effects (ADR).

The unwanted effects of the drug are not affected by the dosage, age, gender and race of the patient.

Common, ADR> 1/100

Neuroscope: drowsiness, fatigue, headache, insomnia, dizziness,

digestive: nausea, indigestion,

Infection: viral infection (colds, flu), upper respiratory infections, coughs, fever, otitis media, sinusitis.

Other: itchy throat, dysmenorrhea, back pain.

Uncommon, 1/1000

No report.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Hypersensitivity to any ingredients of the drug.

Not for children under 12 years old.

Be cautious when using

for the elderly, patients with liver failure or kidney failure.

For people who are driving and operating machinery.

Be careful to monitor (patients or drugs when using fexofenadin for people who are at risk of cardiovascular disease or have a long time before.

Do not use any other antihistamine drugs while using fexofenadin.

The ability to drive and operate machinery

Although Fexofenadin is less likely to be drowsiness, it still needs to be cautious when driving or operating machinery.

Pregnancy

Because there is no complete research on pregnant women, only fexofenadin is used for pregnant women when the benefit of the mother is superior to the risk of the fetus.

Breastfeeding period

It is not clear whether the drug is excreted in milk or not so it is necessary to be cautious when using fexofenadin for breastfeeding women.

Drug interaction

erythromycin and ketoconazole increases concentration and area under the concentration curve - the time of fexofenadin in the blood, the mechanism may be due to increased absorption and reduction of this drug. However, the interaction does not mean clinically.

Aluminum and Magnesi antacids, if used simultaneously with fexofenadin, will reduce the absorption of the drug. Therefore, these drugs must be used for about 2 hours apart.

Storage

temperature below 30 ° C, avoid moisture and light.

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